Sentences with phrase «comparing mice and human»

Studies comparing the mouse and human sequences that accompany the mouse genome in the journal Nature suggest it provides plenty of new leads in biology and disease.

They have also compared the mouse and human genomes, which together are expected to help researchers find genes for diseases and lead to new treatments for human illness.

Not exact matches

Compared with mice with cells from healthy people as well as non-chimera mice, those whose brains had human schizophrenia cells were more afraid to explore a maze, more anxious, more antisocial, less able to feel pleasure (from sipping sugar water), worse at remembering, and more sleepless — all of which characterize people with schizophrenia, too.

Recent collaborative work between UCR and Cedars - Sinai Medical Center in Los Angeles demonstrated that in animal models of human breast cancer, mice treated with 123B9 that was conjugated with paclitaxel had significantly fewer circulating cancer cells in the blood compared to mice that were not treated or even treated with paclitaxel alone.

The researchers have compared various processes involved in gene expression, such as gene transcription and chromatin modification, and have repeated this in different tissues and cell types from both humans and mice.

The scientists have detailed the functional parts of the mouse genome and have compared them with those in humans.

More importantly, within the afflicted groups, both the mice and humans had similarly poor performance in the hidden target trials, making the Morris Maze Test a useful tool for comparing our two species, the researchers say.

Then they compared the results with the genetically modified mice, as well with healthy humans and mice.

Compared with earlier methods to tweak the genomes of bacteria, plants, laboratory mice and human cells, the Crispr - Cas9 gene - editing method is fast, precise and cheap, an order of magnitude better than the others.

It's hard to compare sugar doses between humans and mice, which expend more energy relative to body weight than humans.

By comparing our genetic make - up to the genomes of mice, chimps and a menagerie of other species (rats, chickens, dogs, pufferfish, the microscopic worm Caenorhabditis elegans, the fruit fly Drosophila melanogaster and many bacteria), scientists have learned a great deal about how genes evolve over time, and gained insights into human diseases.

Bejerano and his colleagues originally noticed ultraconserved elements when they compared the human genome to those of mice, rats and chickens, and found 481 stretches of DNA that were incredibly similar across the species.

«Lactobacillus, themselves, appear to differ in both organization and numbers in a mouse's digestive system compared to a human's, for example,» Patterson said.

To test the hypothesis, Frankland and his team first compared the stability of memories in adult mice versus 17 - day - old mice, which are equivalent to human babies less than a year old.

Pavel Pevzner and Glenn Tesler compared the just - sequenced mouse genome with its human counterpart and analyzed where rearrangements, a common type of genetic mutation, occur.

It highlighted differences in the structure and make up of human NMJs compared with those of mice and rats, which are routinely used in studying neuromuscular diseases.

Andrechek's federally funded study looked at mice containing all subtypes and compared the makeup of the rodent tumors and the way the genes acted, known as gene expression, to human tumor data.

In a study in Proceedings of the National Academy of Sciences, Dr. Snyder and his colleagues compared gene expression in 15 different tissue types in mice and humans.

In the Nature papers, the researchers compared gene transcription, chromatin modification and other processes that control gene activity in a wide range of mouse and human tissues and cell types.

Comparing levels of S1PR2 in people with MS, mice with a similar disease, and healthy humans and mice, the team found the groups with MS or the MS - like disease had higher levels of the protein, meaning the blood - brain barrier was more permeable.

«Mouse and human kidney development compared: Findings may lead to advances in the study and treatment of kidney disease.»

Used together, pemetrexed and gemcitabine doubled life expectancy of mice with human group 3 medulloblastoma, compared to untreated mice.

Most convincing of all, Knight believes, is that when samples of gut bacteria from the jet - lagged humans were transplanted into healthy mice, the animals gained weight, showed increased blood sugar, and had a higher body fat content compared with animals given the bacteria of participants before their flight.

Based on the observation that obese mice, rats, and humans all had elevated serum concentrations of a protein called GDF15 compared to lean controls, Yumei Xiong and colleagues set out to develop therapies derived from the molecule.

The study compared the effectiveness of the new tracer with 11C - choline (already widely used for imaging prostate cancer) in two mouse models and also performed the first PET / CT scan with 11C - sarcosine of a human with prostate cancer.

Mice, compared with humans, are more richly endowed in genes for sex, sense of smell, and immunity against pathogens.

In this respect, it is known that the circulating levels of myostatin protein in humans are considerably lower than in mice [14], [21], raising the possibility that the balance of the relative roles played by myostatin and by these other regulators may have shifted further away from myostatin in humans compared to mice.

-- Mice and humans both have about 30,000 genes - and share 99 % of them - but the mouse genome is shorter than that of humans (2.5 billion letters compared with 2.9 billion)---- About 1,200 new genes have been discovered in the human because of mouse - human genome comparisons.

In a recent review, researchers from the French Institute of Health and Medical Research (INSERM), Atomic Energy Commission (CEA) and University of Paris - Diderot compared the effects of six potential EDs on the function of rat, mouse and human fetal testis at comparable stages of their development.

We compared the sensitivity of performance measures and statistical methods for detecting impairments in hAPP mice and humans with MCI - AD.

A trivalent inactivated seasonal influenza vaccine (TIV) used in humans will be compared directly in mice, ferrets and pigs.

Young mice that expressed high levels of human amyloid - β (but did not have pathological plaques) infected in the brain with Salmonella typhimurium were more likely to survive the infection compared to wild - type mice that did not express the peptide, Tanzi, Moir, and their colleagues found.

Comparing humans and mice has the potential to reveal key features of mammalian biology, and more insights will emerge as more genomes are completed.

To determine whether or not increased DNA gain or loss likely had an evolutionary impact we compared human and mouse gene expression divergence.

When compared with the human genome it was found that the two genomes were of similar size and almost every gene in the human genome has a counterpart in the mouse.

«We discovered that the human DNA sequence, which only had 16 changes in it compared to the chimp sequence, was being expressed differently in mice,» said study author Debra Silver, an assistant professor of molecular genetics and microbiology in the Duke University Medical School.

Comparing the gene catalog to the microbiome gene collections that already existed for humans, mice, and pigs... -LSB-...]

To assess the speed with which both humans and chimpanzees accumulated many small differences in gene sequences accurately, Wu and colleagues in Taiwan and Japan decided to sequence several thousand genes expressed in the brain of the macaque monkey and compare them with available genomic sequences from human, chimpanzee, and mice.

Scientists at Penn State College of Medicine, working alongside an international team of researchers, have produced the most complete encyclopedia of functional elements in the mouse genome to date and compared it to the human genome.

Examination of brain homogenates from immunized TG mice revealed no effect on monomeric human AS as compared with vehicle - treated animals, but a 45 % reduction in oligomeric AS and a trend toward reduction of human AS dimers.

When the researchers compared the timelines for mice and humans, the waves of microbes matched closely.

By looking at and comparing the genomes of humans, mice, cows, and two types of fish, these researchers were able to discern general patterns in what led to the emergence of new life forms in different time periods.

He and colleagues Lawrence Grossman and Derek Wildman compared approximately 10,000 protein coding genes culled from the dolphin genome with comparable genes from 9 other animals: a cow, horse, dog, mouse, human, elephant, opossum, platypus and chicken.

When infused into mice bearing human tumors, CD26high T cells more efficiently reconstituted immunodeficient hosts and persisted long - term compared to other subsets.

The next step is to study the function of macrophages in salamanders and compare them with their human and mouse counterparts.

When the treatment used in humans (recombinant protein) was applied in mice and directly compared to the mRNA therapy, the mRNA therapy was more effective, maintaining 20 percent more clotting activity four days after injection.

(B) Mouse host inflammatory gene transcripts (ifn - α, il - 1β and il - 12) in mouse brains were not induced by implantation of untreated compared to heat - treated human brain homogenMouse host inflammatory gene transcripts (ifn - α, il - 1β and il - 12) in mouse brains were not induced by implantation of untreated compared to heat - treated human brain homogenmouse brains were not induced by implantation of untreated compared to heat - treated human brain homogenates.

In a study in the Proceedings of the National Academy of Sciences, Dr. Snyder and his colleagues compared gene expression in 15 different tissue types in mice and humans.

Humans and pigs are so sensitive to toxins compared to rats, mice, cats, and all these other things, way more sensitive because of the way we process, the way we bioaccumulate.

The Effect of Acetyl - L - carnitine and R - alpha - lipoic acid Treatment in ApoE4 Mouse as a Model of Human Alzheimer's Disease J Neurol Sci 2009 (Mar 31)[Epub ahead of print] We measured age - dependent effects of human ApoE4 on cerebral blood flow (CBF) using ApoE4 transgenic mice compared to age - matched wild - type (WT) mice by use of -LSB-(14) C] iodoantipyrene autoradiogrHuman Alzheimer's Disease J Neurol Sci 2009 (Mar 31)[Epub ahead of print] We measured age - dependent effects of human ApoE4 on cerebral blood flow (CBF) using ApoE4 transgenic mice compared to age - matched wild - type (WT) mice by use of -LSB-(14) C] iodoantipyrene autoradiogrhuman ApoE4 on cerebral blood flow (CBF) using ApoE4 transgenic mice compared to age - matched wild - type (WT) mice by use of -LSB-(14) C] iodoantipyrene autoradiography.