Although elevated dN / dS is a common metric for evidence of selection when
comparing single genes, dN / dS values are much lower for signatures of selection across the entire mitogenome [33].
Not exact matches
What they did not express
compared to their nonhealing counterparts was a
single gene: p21.
When the researchers
compared the mRNA to a library of DNA sequences taken from the dendrites of neurons by James Eberwine of the University of Pennsylvania Medical Center, they found that it came from a
single gene on chromosome X — the human version of which, when mutated, leads to fragile - X syndrome.
Tadashi Matsunaga at the Tokyo University of Agriculture and Technology in Japan and his colleagues
singled out the
genes by
comparing well - known magnetic bacteria to a distantly related magnetic species.
Single - cell differential
gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs,
compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.
Comparing their
gene sequences established that they likely diverged from a
single common ancestor between 1902 and 1921, suggesting HIV has been in human populations for at least that long.
For each
gene, the researchers
compared the number of
single letter mutations that alter the encoded protein versus silent mutations that have no effect.
Studies
comparing identical and fraternal twins suggest there is some heritable component to homosexuality, but no one believes that a
single gene or
genes can make a person gay.
«The chance of the
gene being lost over and over again in the other lineages seems vanishingly small
compared with a
single transfer from a metazoan to a bacteria.»
The team also
compared the 7442
genes found as
single copies in both the cobra and the python with the same
genes in all other land vertebrates sequenced so far.
Carrying two copies of a
single - letter change in the DNA of chromosome 16 led to a 35 per cent increase in activity of the
gene GSPT1 ¬ in men with testicular cancer,
compared with those without.
With CRISPR, researchers can edit a
single gene in healthy cells and
compare them to unchanged cells from the same source.
A more advanced experiment uses «
single - worm PCR» to examine the mechanism of RNAi -
comparing the DNA of worms with identical phenotypes induced either by RNAi or a
gene mutation.
With a
single injection, mice showed improvements in motor coordination, weight gain and longevity
compared to those without this
gene therapy.