Comparisons of these genomes with those of other ancient Eurasian peoples indicate that Canaanite ancestry was split roughly 50 - 50 between the early farmers who settled the Levant and immigrants of Iranian descent who arrived later, between 6,600 and 3,550 years ago.
While the new viruses are related, says Le Van Tan, a researcher at the Oxford University Clinical Research Unit and the first author on the Vietnam paper, initial
comparisons of the genomes suggest that they form two new species.
A comparison of the genomes of present - day southern African populations confirms that our ancestors did not originate from a single group
Comparisons of genome data from various reptiles suggest that the EDC mutations responsible occurred when turtles split off from other reptiles around 250 million years ago.
Not only can
comparisons of genomes assess relatedness, but interactions between specific host and parasite species can also be permanently recorded in the genome via jumping of transposable element DNA from one to the other.
Furthermore,
a comparison of genomes between ten species of fish, including zebrafish and pufferfish, and humans revealed that fish lack the genetic information to make Nogo - A or a similar inhibitor.
Comparison of their genomes, integrated with proteomic and microarray data, with the genomes of Plasmodium falciparum and Plasmodium yoelii revealed a conserved core of 4500 Plasmodium genes in the central regions of the 14 chromosomes and highlighted genes evolving rapidly because of stage - specific selective pressures.
Not exact matches
A human - chimp
comparison revealed some 35 million mutations in the single units
of the overall sequence and also found about 5 million additions to or subtractions from the
genome involving chunks
of DNA sequence.
With all due respect, if you'd read the actual study, you would see that this was not a whole
genome sequence
comparison; rather it was a
comparison of mitochondrial 12S rDNA and 16S rDNA sequences for the purposes
of confirming the species relationship between the Pod Mrcaru lizards (P. sicula), the source population from Pod Kopiste (also P. sicula), and the original indigenous population on Pod Mrcaru (P. mellisellensis).
Through detailed
genome comparisons, sequence - alignment algorithms and other bioinformatics tools run on Los Alamos computers, the Los Alamos team identified features that differentiate among F. tularensis and other novel clinical and environmental Francisella isolates, providing a knowledge base for
comparison of new sequences from clinical or environmental surveys.
The Human
Genome Project, which sequenced the 3 billion pairs
of nucleotide bases in human DNA, was a piece
of cake in
comparison: Epigenetic markers and patterns are different in every tissue type in the human body and also change over time.
However, the results
of more recent phylogenetic analyses, derived from
comparisons between sequences
of specific genes and
of whole
genomes, seemed to point to Ctenophora as the first group that parted company with the lineage from which the rest
of the animal kingdom (including sponges) evolved.
Comparisons of the Neandertal
genome to the
genomes of five present - day humans from different parts
of the world identify a number
of genomic regions that may have been affected by positive selection in ancestral modern humans, including genes involved in metabolism and in cognitive and skeletal development.
Software lines them up based on overlapping stretches
of code and
comparisons with previously sequenced reference
genomes.
The first
comparison of the full
genomes of wolves and dogs has found 36 segments that clearly differ.
Ebola virus
genome plasticity as a marker
of its passaging history: A
comparison of in vitro passaging to non-human primate infection
To identify signs
of a self - domestication process in humans, researchers made a list
of genes associated with domestication features in humans, out
of the
comparison with the
genome in Neanderthals and Denisovans, extinct human species.
«We're working on better ways to sequence viral
genomes from ever - smaller amounts
of starting material, to allow identification and
comparison of samples from diverse sources,» said Szpara, who also is affiliated with Penn State's Huck Institutes
of the Life Sciences.
This cover story is a look at what information has been coming out
of direct genetic
comparisons of the chimpanzee
genome and the human
genome.
They then compared genetic sequences with the
genome of the still common domestic pigeon (Columba livia) and, based on those
comparisons, estimate they captured between 57 and 75 percent
of the passenger pigeon's genetics (assuming that its
genome was roughly the same size as its relative's).
Yet the overall size
of the bat's
genome had remained relatively small in
comparison to other mammals, suggesting that while transposons added new DNA, old DNA must have been removed somehow.
However, based on data now available, we see that the sequence
of the 3 billion nucleotides in any individual
genome is unique in
comparison with the sequence
of another individual's
genome, while the degree
of sequence similarity between the 3 billion nucleotides in any two
genomes is remarkably high.
The authors then combined the new
genomes with thousands
of publicly available
genomes that represent the major groups
of plant - associated bacteria, and included bacteria from multiple plant and non-plant environments, such as the human gut, for
comparison.
«To fully understand the loss
of olfactory receptor genes in the ground tit, further
comparisons need to be made with
genomes of closely related species inhabiting lower altitudes.»
However, they show considerable genetic overlap with present - day domesticated lines from the region,» explains Nils Stein, who directed the
comparison of the ancient
genome with modern
genomes at the Leibniz Institute
of Plant Genetics and Crop Plant Research (IPK), Gatersleben, with the support
of Robbie Waugh and colleagues at the James Hutton Institute, Dundee, Scotland, and Gary Muehlbauer, University
of Minnesota, USA.
The
comparison with other sequenced
genomes revealed that over the course
of great ape evolution, about 90 %
of the
genome has been influenced by natural selection.
This is something that was only detectable in the horse in
comparison to the ancient
genomes, as Przewalski's horses were found to show a proportion
of deleterious mutations similar to domesticated horses.
Also,
comparisons of S. typhi with E. coli and other S. enterica
genomes showed that 204 S. typhi genes are nonfunctioning.
As the researchers report in the 25 October issue
of Nature,
comparison of these two Salmonella enterica
genomes to each other and other microbes should help scientists find better ways to prevent and treat the ailments they trigger.
For
comparison, they also sequenced the
genome of a second, related strain — N315, isolated in 1982 — that resisted most antibiotics but was still susceptible to vancomycin, often considered the antibiotic
of last resort.
In keeping with previous studies comparing much smaller portions
of the chimp and human
genomes, the new
comparison shows incredible similarity between the
genomes.
The chimp
genome sequence, which consists
of 2.8 billion pairs
of DNA letters, will not only tell us much about chimps but a
comparison with the human
genome will also teach us a great deal about ourselves.
Bilde thought the velvet spider's
genome would hold clues to the animal's social behavior and its odd mix
of resilience and fragility, so her team and the Chinese sequencing giant BGI set out to sequence its DNA and, for
comparison, that
of a tarantula.
A
comparison of the carrion and hooded - crow
genomes showed that the sequences are almost identical.
Genome comparison revealed that the great expansion
of several gene families in the deep - sea mussel may be related to its adaptation to the deep sea.
Comparisons with the genes
of modern populations revealed them to be more distinct that the
genomes of modern Scandinavians and Italians.
The results are preliminary, Haussler cautions, but he considers it «a tantalizing hypothesis» that HAR1 is involved in the changes that led to our bigger, more complex cortex.The
comparison turned up 49 places where an accelerated rate
of mutation stood out in the human
genome.
By 2008, almost two dozen computerized
comparisons of human and ape
genomes had come up with hundreds
of pieces
of DNA that might be important.
But because the fetus's sequences were inferred from their parents» gene scans, whole -
genome sequences
of the parents (rather than a
comparison with 900,000 points) are needed to get a complete fetal
genome, Lo says.
Comparison of fungal
genomes also will bring a big payoff for researchers interested in fungal ecology and evolution, Taylor says.
«With a powerful toolbox for the assembly
of difficult
genomes now in place, we hope to soon use
genome comparisons to understand why some animals regenerate, while so many do not.
Ctenophores were the last remaining group
of primitive animals to have a
genome sequenced, so the research allowed the first genetic
comparison of all groups.
Comparison of the data revealed that use
of certain starting points differs in two phases
of embryonic development in particular: Before and after activation
of the embryonic
genome.
Advancements in such
genome sequencing have enabled the scientists to make
comparisons of gene similarity between closely related species — wheat and barley, for example — and more distantly related species such as wheat and maize.
For
comparison, they also sequenced the
genomes of a Late Pleistocene horse that lived about 43,000 years ago, a contemporary donkey, five different domestic horse breeds, and a Przewalski's horse, which is considered the world's only remaining wild horse and a source
of controversy.
Indeed, the
genome comparisons revealed that angiosperms evolved 1179 novel genes, many
of which gave rise to additional related genes to make up whole new gene families, says project co-leader Claude dePamphilis, an evolutionary biologist at Pennsylvania State University, University Park.
Such a
comparison should help sequencers home in on the best strategy for sequencing additional
genomes; already, said Collins, the line
of potential organisms is long.
To help make informative
comparisons, Green et al. sequenced the
genomes of 5 present - day individuals from different parts
of the world: southern Africa, West Africa, Papua New Guinea, China, and western Europe (see map).
Now, with more ways to monitor gene activity during development — and fully sequenced
genomes of various snakes and other reptiles for
comparison — Cohn and graduate student Francisca Leal have tracked the genetic activity in embryonic pythons to see why their legs start, but never finish, developing.
«This approach for data integration will enable the
comparison of single - cell datasets and the ability to dissect the differences between them,» explains Rahul Satija, the study's senior author, who is an assistant professor in NYU's Center for Genomics and Systems Biology and a core faculty member at the New York
Genome Center.