The latest such roster — 271 proteins identified in
a compartment of the cell nucleus called the nucleolus — is a first step toward fully deciphering this organelle, a critical element in the construction of ribosomes, which build proteins.
Not exact matches
They're hoping to find out what controls the size
of the
nucleus, the central
compartment of a
cell that contains the DNA, and other components
of the
cell as it develops into a many -
celled organism.
Previous research conducted at Mount Sinai found that the trafficking
of protein molecules between the
nucleus (the cellular
compartment containing the genetic information
of the
cell) and the cytoplasm is altered in neurodegenerative disease.
Until now, it was not clear how this happens as DNA is usually physically separated from the rest
of the
cell inside a
compartment called the
nucleus.
In healthy
cells, RanGAP helps transport molecules through nuclear pores that connect a
cell's cytoplasm — the liquid that fills most
of a
cell — and the
nucleus — the central
compartment containing genetic material.
(The
nucleus is a
compartment in a
cell where most
of the genetic material is stored.)
At the ASCB / IFCB meeting in Philadelphia, Feric and Brangwynne will take the gravity story one step further on December 8, describing how giant Xenopus egg
cells manage to support thousands
of membrane-less
compartments inside the
nucleus.
Every
cell in the body with a
nucleus (a
compartment in most
cells) has the same complete set
of genes.