Sentences with phrase «complement factor»

One hypothesis is that complement factor H, part of the immune system, may help clear cellular debris from the back of the eye.

So the synthesis of complement factor D would seem to be undesirable.

There is substantial evidence that complement is a key player; indeed, half of all AMD patients have a polymorphism in the negative regulator known as complement factor H.

In March three separate teams announced that they had zeroed in on a DNA sequence on chromosome 1 that carries the gene for complement factor H, a protein involved in regulating inflammation.

Scientists have found that a large amount of the inherited risk for AMD, the leading cause of blindness in the elderly, depends on a variation in a gene that codes for a protein called complement factor H.

All three teams found sections of DNA — haplotypes — that differed and ultimately pinpointed a single - letter difference that changed the amino - acid content of complement factor H. HapMap researchers say that refining the map further will speed up such discoveries, and they plan to release a new version this month that will include 4 million single - nucleotide variants.

Developing a Gene Therapy Against Complement Factors in AMD Rajendra Kumar - Singh, PhD Tufts University (Boston, MA)

Other complement factors also may be associated with an increased risk of macular degeneration.

Columbia University Medical Center and other investigators found that variants of another gene, complement factor B, may be involved in development of AMD.

Lab animals that are unable to synthesise complement factor D become unhealthier, but also gain weight more slowly when put on a fattening diet.

Duke University and other researchers have noted a strong association between development of AMD and presence of a variant of a gene known as complement factor H (CFH).

For example, in 2005, three independent studies found that a common form of blindness is associated with variation in the gene for complement factor H, which produces a protein involved in regulating inflammation.

One such regulatory protein is called complement factor H, and mutations in its gene are associated with AMD.

Specific Aim 1: A complement factor that is constantly active at low levels is the complement component 3, or C3 protein.

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