Now that we have mapped
the complete dog genome, genes involved in both disease and desired traits can be identified much more quickly.
With the recent decoding of
the complete dog genome, this coincidence could aid the search for cures to many devastating types of illness.
After
completing the dog genome sequencing project, the Broad Institute of Harvard and MIT and collaborators are now working on identifying disease genes predisposing to cancer.
Not exact matches
But
complete genomes of the ancient
dogs suggest a simpler story.
Dillon's team, which includes Perri, studied 71
complete mitochondrial
genomes and seven nuclear
genomes of
dogs from more than 20 North American sites, ranging in age from 10,000 to 800 years ago.
UCLA researchers analyzed the
complete genome sequences of 19 wolves; 25 wild
dogs from 10 different countries; and 46 domesticated
dogs from 34 different breeds.
Researchers used it, in conjunction with the
complete genomes of several modern
dogs and wolves, to calculate a genetic mutation rate for canines.
Detailed phylogenetic analyses of several virus genes, some of which used
complete CDV
genomes, revealed that strains from lions and hyenas during the 1993/1994 epidemic were strongly distinct from those in domestic
dogs and wild canids.
Scientists have analyzed the
complete mitochondrial
genomes of 18 prehistoric wolf - and
dog - like animals to show that more than 18,000 years ago,
dogs...
In order to aid selection of «a suitable
dog» for inclusion in the
Genome Sequencing Initiative Dr Cathryn Mellersh has requested that the Health Coordinator of each of the participating breeds
complete a questionnaire to provide information about health concerns in their breed.
In the first of these, received on the 21st June, Dr Haywood stated that «the
genome sequencing had been
completed, that detailed analysis of the data from six of the
dogs had been carried out over the summer and that Dr Cathryn Mellersh and the geneticists at the AHT would now be extending the analysis to cover the remaining twenty - nine
dogs».
«
Complete Mitochondrial
Genomes of Ancient Canids Suggest a European Origin of Domestic
Dogs», Nov 15, 2013, Science Magazine.
The University of Minnesota Canine Genetics Laboratory
completed the
genome association study and identified the abnormal gene sequence, then began working on a DNA test to allow for breeding
dogs to be screened.