We have gone from sequencing small fragments of DNA to full mitochondrial genomes (17,000 base pairs of genetic code), and then in the last three years the field exploded into the realm of
complete nuclear genomes.
In 2014 alone, scientists successfully sequenced the mitochondrial genome of a hominin that lived more than 400,000 years ago, 1 exomes from the bones of two Neanderthal individuals more than 40,000 years old, 2 and a nearly
complete nuclear genome from a 45,000 - year - old modern human fossil, 3 to name but a few.
Not exact matches
Dillon's team, which includes Perri, studied 71
complete mitochondrial
genomes and seven
nuclear genomes of dogs from more than 20 North American sites, ranging in age from 10,000 to 800 years ago.
Researchers also have analyzed the
complete nuclear and mtDNA
genomes of another archaic group from Siberia, called the Denisovans.
That precision allows the team to compare the
nuclear genome of this girl, who lived in Siberia's Denisova Cave more than 50,000 years ago, directly to the
genomes of living people, producing a «near -
complete» catalog of the small number of genetic changes that make us different from the Denisovans, who were close relatives of Neandertals.
By comparing this composite Neandertal
genome with the
complete genomes of five living humans from different parts of the world, the researchers found that both Europeans and Asians share 1 % to 4 % of their
nuclear DNA with Neandertals.
Successfully
completing this project will mean that we have developed a groundbreaking method that will provide us with the capability to safeguard the mitochondrial
genome by creating a backup copy in the
nuclear genome.