Working with French composer Richard Krüll, the pair turned
the complete nucleotide sequences of several microbe genes into compositions based on DNA bases: A (adenosine), C (cytosine), G (guanine), and Thymine (which they have translated to «Re,» or D).
In an ambitious study, the authors attempt to trace drug resistance against all strains of the flu by using an extensive influenza virus database containing all known genetic sequence information (70,000
complete nucleotide sequences) for influenza strains.
Not exact matches
In 1972 he and his team were the first to publish the
nucleotide sequence of a
complete gene.
Nextera library construction and Illumina
sequencing provided the most
complete genome assembly and reliable intrahost single -
nucleotide variant (iSNV, frequency > 0.5 %) identification (6).
The 5386
nucleotides of fC became the first
complete DNA to be
sequenced (by Fred Sanger's laboratory in Cambridge in 1977) and Sinsheimer is justifiably proud at having put fC on the map.
Using cutting - edge techniques enabled by next - generation
sequencing, the authors generated
complete methylome maps at single
nucleotide resolution in a low - passage breast cancer cell line and normal breast tissue (primary human mammary epithelial cells).
The resulting consensus
sequences averaged 16,231 ± 455 bp, or 98.1 % of the
complete mitochondrial genome, with the average number of reads per
nucleotide position (fold -
sequence coverage) ranging from 7.4 × to 117 × among the 9 individuals (Supplementary Data 1).