Not exact matches
The emergence of a large
brain, with
complex connectivity among neurons, suggests that the
brain itself is an organ of adaptability.
In humans, the cerebellum's extensive
connectivity with the rest of the
brain suggests it does far more than learn motor skills: it has been shown to have a part in both perception and cognition, with recent work linking cerebellar dysfunction to such
complex diseases as schizophrenia and autism.
«As far as we know, this is one of the first studies of dyslexia to examine differences in functional
connectivity across the whole
brain, shedding light on the
brain networks that crucially support the
complex task of reading,» added Finn.
More recently, I have demonstrated the feasibility of using fMRI in combination with pharmaco - genetic silencing to dissect the circuital basis of
complex behaviors, and demonstrated for the first time that the mouse
brain contains distributed resting - state functional
connectivity networks, including plausible homologues of the human default - mode (DMN) and salience networks.
My main goals are: a) to unravel the functional and anatomical
connectivity of the primate prefrontal cortex circuitry within the framework of
complex cognitive tasks, b) to generate tools and techniques that allow manipulating prefrontal cortex function and therefore generate symptoms of mental disorders in behaving non-human primates, and c) to produce interventions (e.g., deep
brain stimulation or local / systemic drug delivery) that allow rescuing the generated disease phenotypes.
Theoretical and empirical work is beginning to reveal that autism is associated with a
complex functional phenotype characterized by both hypo - and hyper -
connectivity of large - scale
brain systems.
Relationships between functional and structural
connectivity are
complex, even in the neurotypical adult
brain (Damoiseaux and Greicius, 2009), and these relationships undergo significant changes with development (Supekar et al., 2010; Uddin et al., 2011).