Not exact matches
To help make ideas about energy more concrete, for example, the new unit will use a variety of analogies from more familiar physical systems (e.g., combustion and charging a cellphone battery) to help students understand those same energy - releasing and energy - requiring chemical reactions and energy transfer when they occur in living organisms (e.g.,
cellular respiration, creating a charge across a
membrane in mitochondria and nerve cells) where the reactions are more
complex and difficult to observe.
Dr. Jan Höpker, Dr. Silke Oeljeklaus, Prof. Dr. Nikolaus Pfanner, Dr. Sebastian Stiller, Prof. Dr. Bettina Warscheid, Prof. Dr. Nils Wiedemann and their team of researchers have demonstrated that this protein
complex is essential for the integration of certain proteins into the inner
membrane of mitochondria — proteins that play a role in
cellular respiration and other processes.
OPTN may act by regulating
membrane trafficking and
cellular morphogenesis via a
complex that contains Rab8 and hungtingtin (HD).
Such work yields unique mechanistic insight by directly illustrating the
complex spatial - temporal dynamics of fundamental
cellular processes such as mitosis, morphogenesis, polarization, embryonic development,
membrane trafficking and cytoskeleton dynamics.
Aβ is believed to penetrate neuronal plasma
membranes, where it leads to lipid peroxidation.10 It has also been implicated in deactivating a subunit of the pyruvate dehydrogenase
complex, thereby inhibiting conversion of pyruvate to acetyl CoA and the eventual production of
cellular energy as ATP.32 Another way Aβ affects glucose metabolism in the brain is that fragments of Aβ disrupt insulin signaling by binding to neuronal synapses, which alters their shape and function.15, 38 Insulin receptors are abundant at synapses, so if the integrity of the synapse itself has been compromised, the receptors won't function effectively.