Sentences with phrase «complex disease involving»

Cancer is a complex disease involving numerous changes in cell physiology including the metabolic process on how it may be fed.

As you might expect for a major genome center, there are many projects from small family - based studies to large trio studies to massive studies of complex disease involving thousands of unrelated samples.

«Alzheimer's is a complex disease involving multiple factors,» said Stephen Freedman, PhD, vice president of corporate liaison and ventures at Gladstone.

The naïve moralism in this area can be maintained only by ignoring the facts that inebriety is as much a symptom as a cause of the disturbed interpersonal life of the alcoholic, that alcoholism is a complex disease involving physical, cultural, and socio - psychological as well as moral factors, and that homelessness is in itself a complex phenomenon, not the simple product of excessive drinking.

Not exact matches

«Many diseases, especially complex diseases, involve multiple genes, and this system could be used therapeutically to target and activate multiple genes together and rescue these disease phenotypes,» says Albert Cheng, a graduate student in the Jaenisch lab and co-author of the Cell Research paper.

Scientists have shifted from studying single molecules to investigating large complexes of interacting biological macromolecules involved in processes such as metabolic pathways, gene expression, and development of disease.

A team from the Spanish National Cancer Research Centre (CNIO) has determined for the first time the high - resolution structure of a complex (R2TP) involved in key processes for cell survival and in diseases such as cancer.

The disease is so complicated, he says, because it involves two of the body's more complex systems — the nervous and immune systems.

«One of our killifish mutants recapitulates, but in a rapid manner, a human disease called Dyskeratosis congenita, which is due to deficits in a complex involved in maintaining the end of chromosomes, or telomeres,» says lead author Dr. Itamar Harel, a postdoctoral research fellow in genetics.

Called the HapMap, this catalog has made the use of SNPs to track down genes involved in complex diseases — so - called genome - wide association studies — a reality.

Anorexia nervosa is a complex disease, involving psychological, sociological and physiological components.

While the disease is caused by a single gene mutation, the manifestation of the disease at a molecular level is nevertheless highly complex and involves multiple cellular processes.

«Yes, there is a set of diseases that occur more frequently in blacks, but they're complex diseases, involving multiple environmental factors and multiple genes too.

«Crohn's disease is a complex disorder with multiple genes and environmental factors involved, which disproportionally affects individuals of Ashkenazi Jewish ancestry,» explained lead researcher Inga Peter, Professor of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai in New York City.

«We can't start talking about improved treatments for Maya because diabetes is a very complex disease, involving lots of yet unknown risk factors, says Teresa Tusié Luna, a human geneticist who studies diabetes at the Salvador Zubirán National Institute of Health Sciences and Nutrition in Mexico City.

According to Halassa, the new research sets the stage for ever more detailed studies on the complex behavior involved in how the mammalian brain pays attention to what's important, and especially how those neural circuits are broken in cases of attention - deficit diseases, such as ADHD, autism, and schizophrenia.

Articles focus on topics including how healthy relationships early in life affect physical and mental health in childhood and beyond; the role of intimate relationships in coronary heart disease; the need to focus on partners when treating someone with chronic disease; and the increasingly complex biological pathways involved linking relationships to health.

Such disorders are caused by complex interactions among genes and environmental factors; the challenge facing researchers now is to find out which genes are involved and how they influence disease.

Until now, however, nobody has found any evidence that apoptosis is involved in diseases caused by more complex parasitic organisms.

One is to identify disease genes — particularly those involved in conditions with complex origins, such as asthma and heart disease — by comparing genetic sequences within a group of patients with a given disease.

While effective, the downside to these approaches to vision rescue is that each disease requires its own form of gene therapy to correct the particular genetic mutation involved, a time consuming and complex process.

The «active cell map» is the set of all interactions, complexes and pathways involving molecules in the cell and their activity under normal and diseased regulatory circumstances.

More broadly, said Campbell, «we believe our findings open up a completely new avenue of research involving the functional role of this complex in vascular smooth muscle and its possible involvement in coronary artery disease in general.»

However, prevailing GWA data analysis methods are focusing on the association of individual SNP alleles with a complex disease, although multiple alleles are involved by definition.

Their discovery — which involved the work of both neuroscientists and geneticists — underscores the importance of collaborative and cross-disciplinary research when dealing with complex neurodegenerative diseases such as ALS.

Genome - wide association studies are a critical tool in the detection of genes involved in complex diseases such as diabetes and cancer or traits such as height and obesity.

This study of human genetic variation and its relationship to health and disease involves a large number of study participants and will capture not only common single nucleotide variations but also rare copy number and structural variants that are increasingly thought to play an important role in complex disease.

Alzheimer's is a complex disease, and there are multiple elements involved.»

While environmental factors play a role in developing T2D, it is also highly heritable — and the genetics involved are complex, with many genes contributing to disease risk.

Ultimately, we aim to reveal the key species (cultured and uncultivated) involved in dental caries and provide new insights into specific genes / domains, gene products, and metabolic pathways that define the synergistic and competitive contributions to health and disease in this complex microbial community.

• Disease - driving pathways that involve the human immune system are often targeted by antibodies, and Organ - Chips recreate complex interactions of different human cell types and aspects of the human immune system, overcoming limitations of animal models which do not reflect all human immune cells.

Genes and mechanisms involved in common complex diseases, such as the autoimmune disorders that affect approximately 5 % of the population, remain obscure.

This represents an important step forward for mapping genes involved in complex diseases.

To find variants involved in complex diseases, thousands of participants may be necessary — a logistical and financial demand often beyond the capacity of an individual research team.

My long - term research interests involve understanding the complex mechanisms underlying transcriptional regulation of human disease.

The relationship between viral infection and autoimmune disease is multifaceted, involving numerous complex processes in the body.

The relationship between viral infection and autoimmune diseases such as Hashimoto's hypothyroidism is multifaceted, involving numerous complex processes in the body.

Health and disease are conditions of the entire organism, involving a complex interaction of physical, spiritual, mental, emotional, genetic, environmental, and social factors.

Also, the process of trying to modify our genomes so that we become resistant to certain complex diseases is obviously not simple and straight - forward, seeing as most diseases involve the expression of thousands of genes.

A 2016 study by researchers from the Buck Institute for Research on Ageing and the UCLA Easton Laboratories for Neurodegenerative Disease Research, showed that memory loss in Alzheimer's patients can be reversed, and improvement sustained, using a complex, 36 - point therapeutic personalized program that involves comprehensive changes in diet, brain stimulation, exercise, optimization of sleep, specific pharmaceuticals and vitamins, and multiple additional steps that affect brain chemistry.

The kidneys are so integral to all other health issues and seem to be involved in just about every disease process in some way or other, very complex.

Functional medicine involves understanding the origins, prevention, and treatment of complex, chronic disease.

Over the last 23 years, Dr. Turpel has successfully performed more than 2000 orthopedic procedures involving Cranial Cruciate Ligament (CCL) injuries, patellar luxation, hip disease, amputations, OCD lesions, and simple to complex fractures.

Modes of inheritance for these diseases are not fully known and are likely to be complex, with multiple genes involved.

In addition to being an educational resource for you, our board certified veterinary dentists offer specialty services in complex cases involving dental disease or injury.

Board Certified Veterinary Dentists offer specialty services in complex cases involving dental disease or injury.

As National Pet Dental Month rapidly draws to a close, let's take a moment to discuss a case involving extensive oral disease (also known as gingivitis / stomatitis complex) in a cat caused by Bartonella.

Undoubtedly, CDRM has a complex aetiology which probably involves several different factors but most authors agree there is almost certainly a genetic factor due to the very high incidence of the disease in one breed.

Branch first became involved with complex litigation in 1989 with EMS (Eosinophilia Myalgia Syndrome, a neurological disease, linked to the ingestion of the bio-engineered amino acid, L - Tryptophan) and has since been involved in Norplant ®, Fen Phen, Rezulin ®, Baycol ®, Vioxx ®, and Avandia ®.

This anonymously operated beneficiary donated a total of $ 1 million to the Open Medicine Foundation, an organization involved in research for ME / CFS (myalgia encephalomyelitis / chronic fatigue syndrome) and other related chronic complex diseases.