Sentences with phrase «complex diseases using»

38/3: 15 Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis.

This work underscores the feasibility and power of studying common complex diseases using Iceland's unique resources.»

Not exact matches

At the Challenge Festival, startups like as BaseTrace, which «uses DNA - based tracers to track where industrial fluids are going in large, complex environments» and Reliefwatch, a cloud - based system that uses smartphone technology to track inventory and diseases for healthcare organizations in the developing world, battled it out on stage for a grand prize of $ 150,000 in investment.

CVS will extend use of Epic's EHR technology to its specialty care programs for managing complex and chronic medical conditions and rare diseases, the company announced on Friday.

«They could potentially carry out complex programs that could be used to diagnose or treat diseases with unprecedented sophistication,» says Daniel Levner, a bioengineer at the Wyss Institute at Harvard University.

It also sought to match epigenetic changes and genetic differences to the physical characteristics of each cell type and use this knowledge to understand how these can lead to blood disorders, cancer and other complex diseases.

The advantages of MFCs may allow widespread use of diagnostic procedures that are currently too expensive to implement (e.g., prescreening for cancer) while the new capabilities may dramatically improve our ability to understand complex diseases such as cancer (e.g., through single - cell analysis).

«Many diseases, especially complex diseases, involve multiple genes, and this system could be used therapeutically to target and activate multiple genes together and rescue these disease phenotypes,» says Albert Cheng, a graduate student in the Jaenisch lab and co-author of the Cell Research paper.

DNA testing companies use the SNPs to calculate people's genetic risk of developing complex diseases.

«TB is a complex disease and modelling it is difficult but we've successfully used our model to replicate real world situations and are confident that it can be used to predict the effects of various changes in the way we tackle the disease.»

This essentially gives us «barcodes» of specific gene loci, which we can use to help untangle the complex genetics of complex diseases,» said Andrey Rzhetsky, PhD, professor of genetic medicine and human genetics at the University of Chicago, who led the study.

Called the HapMap, this catalog has made the use of SNPs to track down genes involved in complex diseases — so - called genome - wide association studies — a reality.

The hope is the technique could be used to unpick the role of proteins in many complex processes, such as the consolidation of memories, or be used to block the interactions between proteins within cells to help illuminate the processes that underpin disease.

Using advanced computer models, neuroscience researchers at the University of Copenhagen have gained new knowledge about the complex processes that cause Parkinson's disease.

«It might be useful for orientation and mobility specialists who teach people with eye diseases how to efficiently use their remaining vision to negotiate the complex world we live in,» he says.

Watterson envisions that an array of drugs eventually will be used to treat Alzheimer's and other complex neurological diseases.

The researchers said the work demonstrates that, in fact, multi-tissue, multi-individual data can be used to identify the mechanisms of gene regulation and help to study the genetic basis of complex diseases.

Many researchers are already using stem cell lines in drug development, and to further understanding of often - complex diseases.

«A pathological and very complex autoimmune reaction of the skin»: This is the definition doctors and scientists use to describe psoriasis, a disease that affects one to three percent of the population.

A $ 1.6 million effort to study the complex mechanisms of the disease and identify existing drugs that might be able to be used for Alzheimer's treatment or prevention, led by Eric Schadt of Icahn School of Medicine at Mount Sinai in New York City.

Will you now use family genome sequencing to study other, more common and complex diseases?

Using cutting edge «disease in a dish» technologies, the researchers are now following up the leads discovered in blood cell lines in neurons induced from stem cells derived from the blood of PMDD patients — in hopes of gaining a more direct window into the ESC / E (Z) complex's role in the brain.

Buckler is credited with improving association mapping, one of the methods used for this research, that is being used to understand the genetic basis of such complex traits as vitamin A content, drought tolerance, nitrogen use, carbon metabolism, disease resistance, and crop and milk yields.

The purpose of this perspective, then, is to provide a logical argument for a new approach to classifying human disease that both appreciates the uses and limits of reductionism and incorporates the tenets of the non ‐ reductionist approach of complex systems analysis.

We're excited to join forces with a company that has demonstrated scientific leadership using gene discovery to address the therapeutic challenges of complex human diseases.»

To better understand this complex tissues and its functions — and the diseases that affect it — a multicenter team led by researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital has released a census of the cells that make up the lining of the small intestine, using gene expression profiles of more than 53,000 individual cells from the mouse gut or gut organoid models.

Using deCODE's proprietary analysis tool for complex traits, the deCODE Clinical Genome Miner ™, the researchers were able to correlate a wide range of clinical, behavioral, and genotypic data, and gained important new insights into the heritability of different aspects of obesity, as well as into the complex interplay between obesity and diabetes, stroke, heart disease, and hyperlipidemia.

This novel approach, which reveals complex interactions between cells and proteins, can also be used for other diseases to generate new knowledge about the regulation and dysregulation of the immune system, which can eventually give rise to new, improved immunological therapies.

Stem cells are characterized by their ability to both reproduce themselves and to differentiate into functional tissues, foundational properties that enable their use as the starting material for manufacture of cellular therapeutics to address complex disease.

He and the Vereide Group grow precursors of human arterial cells, build colonies of dendritic cells (cells which can alert the rest of the immune system to the presence of a tumor), and use chick embryos to study the formation of early tissue layers for a possible future in which complex tissues, or even organs, can be grown to replace diseased, wounded, or malfunctioning ones.

Continued research may allow HPFM to be used as a probe so, for instance, it would be possible to study the effect of new treatments being developed to save plants such as citrus trees from bacterial diseases rapidly decimating the citrus industry, or study fundamental photonically - induced processes in complex systems such as in solar cell materials or opto - electronic devices.

ANN ARBOR, Mich — By combining engineered polymeric materials known as hydrogels with complex intestinal tissue known as organoids — made from human pluripotent stem cells — researchers have taken an important step toward creating a new technology for controlling the growth of these organoids and using them for treating wounds in the gut that can be caused by disorders such as inflammatory bowel disease (IBD).

Their work builds upon and may potentially supersede several previous approaches to the problem of mitochondrial mutations that occur as a result of the degenerative aging process, including allotopic protein expression, (6) its optimization using an MTS, (3 - 5) and the exploitation of the multiprotein RNA import complex (RIC) of the protozoal parasite Leishmania tropica (7)(which the investigators characterize as «requir [ing] the introduction of nonnative tRNAs with foreign protein factors or the transfer of a large multisubunit aggregate into cells, which is of low efficiency and difficult to reproduce in desirable disease - relevant settings» (2)-RRB-.

We are now using these models to study the gene function and complex mechanisms underlying disease pathways, with a focus on genetic background effects, genetic modifiers and interaction partners.

Now, scientists from the University of Chicago have created one of the most expansive analyses to date of the genetic factors at play in complex diseases — by using disorders with known genetic causes to guide them.

Biomedcode offers preclinical testing using complex mouse models closely recapitulating the complexity of human disease as they also exhibit co-developing pathologies also observed in human patients.

For custom gene expression projects the Genomics Core has a platform that uses sets of human and mouse custom arrays whose probe content is aimed at gene expression studies in the areas of cancer, immunology and other complex diseases.

Just as we can now effectively treat HIV - infected patients with a cocktail of antiretroviral drugs — and we treat people with hypertension using diuretics, beta blockers and other drugs — we expect to treat patients with complex neurological conditions with drug combinations that target both the worst symptoms and the root causes of the diseases.

Her laboratory focuses on (1) the use of next generation sequencing to define the microbiome and host immunologic features in patients with human diseases and (2) developing custom computational tools for the identification of novel human commensals and pathogens in these inpatient populations, and (3) using statistical and functional biological methods to understand the complex interplay between the human microbiome and host biology.

Therefore, these tiny microRNAs can potentially be used to treat complex diseases as AMD without having to perform extensive screening for small molecule drugs.

«The general feeling in the field used to be that stem cell therapy for Alzheimer's was not feasible, because the disease was too complex and too many cells would need to be replaced,» said Yadong Huang, MD, PhD, a senior investigator at the Gladstone Institutes.

132/5: 15 Complex diseases are associated with variation in Mendelian genes: A phenome - wide study using Human Phenotype Ontology and a population genotyped on the Exome BeadChip.

Many researchers are already using stem - cell lines in drug development and to further understanding of often - complex diseases.

«The Knapps have applied their remarkable energy and resources — including hard work — to finding better ways to learn about complex diseases such as lupus and to use that knowledge to help others,» said James Madara, MD, dean of the biological sciences and the Pritzker School of Medicine and vice president for medical affairs.

Steven Munger, Ph.D., uses a systems genetics approach and advanced computational methods to study development and complex disease in...

Specifically, the authors call for systems biology approaches (using large data sets and modeling to understand complex biological systems) to fill critical knowledge gaps in understanding how Mycobacterium tuberculosis (Mtb) infection causes disease.

Dr. Edman specializes in teaching and coaching employees, clients, the public, and practitioners about the most effective use of nutritional and integrative or Functional Medicine therapies for everything from chronic and complex symptoms and disorders to wellness and disease prevention.

I often think that medical doctors are trying to find the right nutrient or right essential atom to treat a disease, and use a complex mixture instead.

1935 Effects of the high carbohydrate - low calorie diet upon carbohydrate tolerance in diabetes mellitus 1955 Low - fat diet and therapeutic doses of insulin in diabetes mellitus 1958 Effect of rice diet on diabetes mellitus associated with vascular disease 1976 Beneficial effects of a high carbohydrate, high fiber diet on hyperglycemic diabetic men 1977 Effect of carbohydrate restriction and high carbohydrates diets on men with chemical diabetes 1979 High - carbohydrate, high - fiber diets for insulin - treated men with diabetes mellitus 1981 High carbohydrate high in fibre diet in diabetes 1982 Response of non-insulin-dependent diabetic patients to an intensive program of diet and exercise 1983 Long - term use of a high - complex - carbohydrate, high - fiber, low - fat diet and exercise in the treatment of NIDDM patients 1994 Diet and exercise in the treatment of NIDDM: the need for early emphasis 1999 Toward improved management of NIDDM: A randomized, controlled, pilot intervention using a lowfat, vegetarian diet 2005 The effects of a low - fat, plant - based dietary intervention on body weight, metabolism, and insulin sensitivity 2006 A low - fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes 2006 Effect of short ‐ term Pritikin diet therapy on the metabolic syndrome 2009 A low - fat vegan diet and a conventional diabetes diet in the treatment of type 2 diabetes: a randomized, controlled, 74 - wk clinical trial

With so many people suffering from complex, chronic diseases such as cancer, diabetes, congenital heart disease and autoimmune disorders, too many physicians remain oriented toward using prescribed treatments such as drugs or surgery to treat the problem or symptoms.