Sentences with phrase «complex gene interaction»

This means one can see that one is dealing with a complex gene interaction,» Crona said.

Conventional methods for identifying complex gene interactions rely on precise measurements of the genetic fitness of mutants.

Not exact matches

«The interaction of genes, environment and nurture come together in complex ways to produce the variety of human behavior.»

The issue should be understood as «which is more important, the individual replicator (the gene), or the patterns generated by interactions of a myriad of replicators with a complex environment?»

«There's a complex interaction between genes and environment,» says Grisham.

Standard approaches also struggle to find combinations of multiple genes that affect disease risk in complex ways (known as genetic interactions).

They achieved this by transiently disturbing interactions between target genes and PcG proteins, which are complexes involved in the repression of several genes governing development.

James Collins, a professor of biomedical engineering at Boston University who was not associated with this research, says, «Efforts in synthetic biology to create complex gene circuits are often hindered by unanticipated or uncharacterized interactions between submodules of the circuits.

Rather than despairing that combinatorial interactions of diets, nuclear genes, and mitochondrial genes make the underlying biology of aging intractably complex, Rand and lead author Chen - Tseh Zhu said studies that explicitly embrace such multifactorial interactions can lead researchers to understand the inherent biological complexity of the aging process: Many genes, many cells, and many environments all contribute to the aging process.

The outcome is determined by a complex interaction between depression gene versions and environmental factors.

«Like cancer, autism is a very complex disease,» says Craig Newschaffer, chairman of Epidemiology and Biostatistics at the Drexel University School of Public Health, «and it's exciting to start asking questions about the interaction between genes and environment.

«While previous molecular studies have provided simple snapshots of the gene transcript variations that are associated with the exposure of insects to natural and synthetic chemicals, the genomics approaches used in this study offer a significantly more complex perspective on the biochemical and physiological processes occurring in plant - insect interactions,» Schuler said.

«This is a complex genetic disorder caused by the interaction of a number of genes and the environment,» Blair stresses.

Such disorders are caused by complex interactions among genes and environmental factors; the challenge facing researchers now is to find out which genes are involved and how they influence disease.

A new technique produces complex maps of gene interactions and how they change as cells mature.

One of the gene's molecular targets, for example, is a microRNA (a small noncoding RNA molecule) called let7, which in turn regulates hundreds of other genes, so the effects of Lin28a can set off a complex array of regulatory interactions.

They modernized the factory by updating the carboxysome, a particularly complex BMC that requires a series of protein - protein interactions involving at least six gene products to form a metabolic core that takes CO2 out of the atmosphere and converts it into sugar.

Cancer researchers have applied a comprehensive set of analytical tools to lethal cases of metastatic prostate cancer, yielding a detailed map of the complex networks of interactions among genes and proteins that enable prostate cancer cells to proliferate and evade treatment.

By representing data in BioPAX, Pathway Commons is able to provide a detailed representation of a variety of biological concepts including: Biochemical reactions; gene regulatory networks; and genetic interactions; transport and catalysis events; and physical interactions involving proteins, DNA, RNA and small molecules and complexes.

Thus, neural derivatives of disease - specific human pluripotent stem cells constitute a relevant biological resource for exploring the impact of adult - onset HD mutations of the HTT gene on the division of neural progenitors, with potential applications in HD drug discovery targeting HTT - dynein - p150Glued complex interactions.

Details that can be included are biochemical reactions; gene regulatory networks; genetic interactions; proteins, small molecules, DNA, RNA, complexes and their cellular locations; complex assembly and transport; post-translational protein modifications; citations; experimental evidence; and links to other databases e.g. protein sequence annotation.

«We suggest that such abundant and complex transcription may increase gene - gene interactions and constrains coding - sequence evolution.»

With investigations of the conformational properties and interaction stoichiometry of polyribonucleotides of simple and complex sequence (7) and the separation of the complementary strands of DNA and then their renaturation to biologically active duplexes (8), the groundwork was laid for the complementary strand annealing that proved so critical in making gene cloning possible.

At any given instant it can be argued that the cell is in a «state» defined by its components — their concentrations and locations, the interactions between components — that are modulated in space and time, and the complex circuitry — that involves a large number of interacting networks and a snapshot of the dynamical processes — such as gene expression, cell cycle, transport of components, etc..

The idea behind our work in bioinformatics is to build on existing methodologies regarding large - scale data analysis and to develop novel algorithms for processing and merging complex biological data from multiple sources such as gene expression data, sequence information, protein - to - protein interaction data, clinico - pathological data etc..

Striking sex and regional differences in the increase of obesity - related T2DM prevalence developed throughout the last 3 decades, reflecting complex relationships with differences in ethnicity, migration, culture, lifestyle, gene - environment interactions, socioeconomic status (SES) and social roles (12).

We are now using these models to study the gene function and complex mechanisms underlying disease pathways, with a focus on genetic background effects, genetic modifiers and interaction partners.

While this is a much more complex and daunting undertaking, by understanding the functions and network interactions of genes and proteins — both human and microbe — we will ultimately gain far greater insight into human health and reveal more solutions to dread diseases.

Biologists have built models of molecular interaction networks that represent the complex relationships between thousands of different genes.

It is believed that T1D results from complex interactions between multiple genes, environmental factors and the immune system, and the autoimmune aspects may begin many years before the clinical manifestation of T1D.

Understanding the metabolism and gene expression profiles as well as inter-species interactions within these complex microbial communities are necessary steps in studying the diseases and finding new treatment solutions.

70/3: 15 Chromosome interaction analysis of risk loci in related autoimmune diseases reveals complex, long - range promoter interactions implicating novel candidate genes.

In conclusion, our study highlights the importance of studying gene — gene interactions in complex diseases and provides insights into the underlying cellular and molecular mechanisms.

Most experts believe that the majority of Alzheimer's disease occurs as a result of complex interactions among genes and other risk factors.

Though weight, and that includes overweight, is the result of a complex set of interactions between an individual's genes, behavior, and the environment, at its simplest, as a recent National Institutes of Health report states, our size is the result of «a balance between energy intake and energy expenditures.»

Structure is controlled by genes that affect bones, muscles, tendons, ligaments, and growth rate, and health depends on gene interaction as simple as that governing progressive retinal atrophy (the dog either has it or he doesn't; there's no halfway) or as complex as that influencing various autoimmune diseases, seizures, or various circulatory defects.

Due to the complex interactions of these genes, it is possible for dogs to carry hidden colors which may appear in their offspring.

The results are consistent with other biological studies which point to the likely interaction of several genes in producing complex disorders such as autism [36] and schizophrenia [37].

Behavioural genetics studies examining the association between polymorphisms of the serotonin transporter gene and affective disorders (Uher & McGuffin 2008) as well as the association between environmental interactions with the serotonin transporter gene and affective disorders (Munafo et al. 2009; Risch et al. 2009) within a given population often produce inconsistent results, suggesting a more complex path from gene to disease.

Boyce et al have looked at stress reactivity in children and have shown that a high degree of variability exists.21 Traditionally, genetic predispositions were thought to play a major role in determining stress reactivity, but more recent data suggest that previous experiences also play an important role.22 Stress reactivity, much like brain development itself, results from a complex, dynamic interaction between genes (nature) and the environment (nurture) over time.