Sentences with phrase «complex gene structures»

The data is manually curated, which is more accurate at identifying splice variants, pseudogenes poly (A) features, non-coding and complex gene structures and arrangements than current automated methods.

Not exact matches

EPFL biologists and geneticists have uncovered how the circadian clock orchestrates the 24 - hour cycle of gene expression by regulating the structure of chromatin, the tightly wound DNA - protein complex of the cell.

These suggest a complex history that may represent early gene flow across Eurasia or an early population structure that eventually led to Europeans and Asians.

The study identifies a wide set of genes — previously associated with complex structures in higher animals — which were supposedly absent in sponges.

The 3 angstrom resolution crystal structure of the Escherichia coli catabolite gene activator protein (CAP) complexed with a 30 - base pair DNA sequence shows that the DNA is bent by 90 degrees.

Rutgers University scientists have discovered the three - dimensional structure of a gene - specific transcription activation complex, providing the first structural and mechanistic description of the process cells use to turn on, or activate, specific genes in response to changes in cell type, developmental state and environment.

Bioinformatic approaches to the analysis of genetic variability and complex genotype - phenotype relationships will moreover include gene sequence and database analyses, measures of association of haplotypes / genotypes with phenotype, clustering procedures, neuronal networks, fuzzy and other techniques in pattern recognition, similarity measures for discrete patterns (e.g., gene sequences, structures, functions), logistic regression methods, and a spectrum of other techniques.

«Our hypothesis is that structures conserved in RNA are like a common template for regulating gene expression in mammals — and that this could even be extrapolated to vertebrates and less complex organisms.»

«We found that Asgard archaea share many genes uniquely with eukaryotes, including several genes that are involved in the formation of structures that give eukaryotic cells their complex character.

By probing the three dimensional structure of this protein complex, called RNA - Induced Initiation of Transcriptional gene Silencing (RITS), scientists from Cold Spring Harbor Laboratory (CSHL) and their collaborators at St. Jude's Research Hospital have discovered new details of how its various parts or «domains» contribute to heterochromatin assembly and gene silencing.

As we have done to elucidate complex diseases, 6 for each projection on the blood causal network structure, we identified the largest connected subnetworks comprising genes directly connected to the projected module genes, resulting in the identification of relaxation - and meditation - specific subnetworks (Figure 3).

Crystal structure of a Cas9 in complex with an RNA guide and a stretch of target DNAWIKIMEDIA, H. NISHIMASU ET AL.. A team of researchers at the Gladstone Institutes in San Francisco, California, has used a version of CRISPR gene editing known as CRISPR interference (CRISPRi) to reversibly and accurately suppress gene expression in induced pluripotent stem cells (iPSCs) and derivative T cells and heart cells, according to a study published in Cell Stem Cell today (March 10).

Talks will discuss the origination of novel cell type gene regulatory networks, and cover the latest research into the evolution of cell type functional modules, such as protein complexes and larger macromolecular structures.

We show that most genes encoding olfactory and vomeronasal receptors have complex, multi-exonic structures that generate different isoforms.

These laboratories are complemented by several additional laboratories: one that is focused on computational structure prediction and design (Phil Bradley), one that conducts solution - based protein mapping studies of large complexes involved in gene transcription (Steve Hahn) and a third that conducts drug target validation and drug screening studies (Julian Simon).

This surprising genome structure is generated and reinforced by two essential protein complexes that bridge the loops and contribute to proper gene regulation.

The classic data of bioinformatics include DNA sequences of genes or full genomes; amino acid sequences of proteins; and three - dimensional structures of proteins, nucleic acids and protein — nucleic acid complexes.

Structure is controlled by genes that affect bones, muscles, tendons, ligaments, and growth rate, and health depends on gene interaction as simple as that governing progressive retinal atrophy (the dog either has it or he doesn't; there's no halfway) or as complex as that influencing various autoimmune diseases, seizures, or various circulatory defects.

The gene product's precise role is not currently understood but it is thought to anchor regulatory complexes at the photoreceptor connecting cilium, which acts as a bridge between the inner and outer segments of photoreceptor cells [43] as well as having functions in disk morphogenesis [42] and in the structure of the ciliary axoneme [44].