In a comprehensive and
complex molecular study of blood samples from Ebola patients in Sierra Leone, published in Cell Host and Microbe, a scientific team led by the University of Wisconsin - Madison has identified signatures of Ebola virus disease that may aid in future treatment efforts.
Not exact matches
The fields within biology are further divided based on the scale at which organisms are
studied and the methods used to
study them: biochemistry examines the fundamental chemistry of life;
molecular biology
studies the
complex interactions of systems of biological molecules; cellular biology examines the basic building block of all life, the cell; physiology examines the physical and chemical functions of the tissues and organ systems of an organism; and ecology examines how various organisms interrelate.
The researchers hope these
study findings will aid in understanding the
complex human reproductive cycle and the occasional problems that originate on a
molecular level.
Liu, who was an investigator at the Children's National Medical Center in Washington DC during the research, decided to
study tissues removed from eight patients with either focal cortical dysplasia or tuberous sclerosis
complex to see if she and her co-authors could discern what might be going awry at the
molecular level.
Hazen says that he and his colleagues are currently extending their
studies to see if similar conditions help give rise to amino acids and other more
complex molecular precursors of life.
According to a
study published on the journal
Molecular Biology and Evolution, most genes involved in
complex processes are present in sponges.
We hope that this will open the door for future
studies to tease apart how these
complex interactions happen,» said Taylor, a PhD student in the
Molecular and Computational Biology Section at USC.
The work speaks to how evolution may tap the same
molecular pathways in very different animals, even for traits as
complex as social behavior, says Hans Hofmann, an evolutionary neuroscientist at the University of Texas in Austin who was not involved with the
study.
The
study provides evidence for how FGF23 signals to cells by forming a
complex with a-Klotho and the two other
molecular partners.
«It's obviously very difficult to
study the
molecular basis of memory because memory involves a fairly
complex activity,» Wolynes said.
For Francisco and Lohmann it took three field expeditions to different states of the Brazilian Amazon, combined with deep morphological and
molecular studies, to set straight uncertainties in the
complex taxonomic history of Pachyptera lianas.
«While previous
molecular studies have provided simple snapshots of the gene transcript variations that are associated with the exposure of insects to natural and synthetic chemicals, the genomics approaches used in this
study offer a significantly more
complex perspective on the biochemical and physiological processes occurring in plant - insect interactions,» Schuler said.
In 2013, Stanford built a sophisticated
molecular biology and genetics lab within the ValBio
complex, where these
studies could be carried out.
«We realized that
studying the lithium response could be used as a «
molecular can - opener» to unravel the
molecular pathway of this
complex disorder, that turns out not to be caused by a defect in a gene, but rather by the posttranslational regulation (phosphorylation) of the product of a gene — in this case, CRMP2, an intracellular protein that regulates neural networks,» added Snyder.
«In order to more easily
study TORC2, we wanted to learn how to make this
complex sensitive to rapamycin» says Robbie Loewith, researcher at the Department of
Molecular Biology of the Faculty of Science from the UNIGE, Switzerland.
Because metastasis is a
complex process that has been difficult to
study, Chicago's Ludwig Center will bring together researchers from various areas of expertise, including
molecular biology, cell biology, genetics, bioinformatics, chemistry, imaging and medicine.
Biologist Helena Safavi, co-author on a paper describing the cone snail insulin published September 12 in Nature Structural &
Molecular Biology, says that
studying complex venom cocktails can open doors to new drug discoveries.
Efforts to
study the
molecular mechanisms that mediate these
complex processes in different anatomical compartments have been impeded by difficulties in the isolation and propagation of endothelial cells from different organs.
Using a combination of
molecular biology, biochemical and novel multi-dimensional digital imaging approaches we
study in real - time
complex multi dimensional signal integration during the interaction of T cells with live antigen - presenting cells.
study identifies 13 clouds in the
molecular gas
complex associated with these stars, with a total of 42610 solar masses in radioactive carbon monoxide (13CO).
The
study published in
Molecular Cell is entitled, «The Short Isoform of BRD4 Promotes HIV - 1 Latency by Engaging Repressive SWI / SNF Chromatin Remodeling
Complexes.»
Such a strategy will require a better understanding of the
molecular mechanisms of antibiotic resistance, so in this
study, the researchers solved the crystal structure of the resistance enzyme aminoglycoside phosphotransferase (4)- Ia in
complex with the aminoglycoside hygromycin B.
A successful candidate should have the following qualifications: a Ph.D. in the field of
Molecular Biology, Cell Biology, Biochemistry or related field; an established track - record of publications in peer - reviewed journals; solid experience in the biochemistry of
complex DNA - binding proteins (such as chromatin remodeling factors or DNA repair proteins), their purification from heterologous expression systems as well as their characterization using functional
studies such as by isothermal titration calorimetry fluorescence, transcription assays.
Finally, the SKA will have the resolution and sensitivity to
study the J = 1 - 0 transitions of amino acids and other
complex carbon bio-molecules, and to follow their progress from
molecular clouds to proto - planets.
The
study demonstrates that evolution often is not a linear process; thanks to modern
molecular methods it's
complex processes are finally revealed.
As a partner of the European Consortium 3D - REPERTOIRE and coordinator of the Spanish Structural Genomics Consortium GENES, our group
studies several protein
complexes and
molecular machines, some of which are related to the epigenetic control of gene expression.
Senior author of the
study Xuetong «Snow» Shen, Ph.D., associate professor in The University of Texas MD Anderson Cancer Center Department of
Molecular Carcinogenesis, developed a unique model system to nail down actin's function in the nucleus: the actin - containing INO80 chromatin remodeling
complex in yeast cells.
«Achieving Reversible H2 / H + Interconversion at Room Temperature with Enzyme - Inspired
Molecular Complexes: A Mechanistic
Study.»
The goal of these integrated
studies is to understand
complex biological systems on a
molecular level.
The computational
study of the
molecular orbitals provides an explanation for the observation that the two metals are closer in the oxidized
complex,» said Dr. Morris Bullock, a PNNL scientist who worked on the
study.
In a second
study, published in
Molecular Cell, Kapoor with collaborators from the laboratories of Drs. Guang Peng and Mark Bedford showed that the INO80 chromatin remodeling
complex helps regulate a Rad53 mediated DNA damage checkpoint.
«Alex's (Marques's) students collect the sand flies, then they extract the parasites in the lab and do
complex mass spectrometry and other tests to
study their
molecular makeup in impressive detail,» Finn said.
Liu, who was an investigator at the Children's National Medical Center in Washington during the research, decided to
study tissues removed from eight patients with either focal cortical dysplasia or tuberous sclerosis
complex to see if she and her co-authors could discern what might be going awry at the
molecular level.
The researchers are
studying how removal of an electron (oxidation) affects the bonding and reactivity of metal hydrides and related
complexes that can be used as
molecular catalysts.
In a
study published in
Molecular & Cellular Proteomics, investigators at the University of Dundee led by Michael Ferguson performed a protein correlation profiling approach using mass spectrometry to identify protein
complexes from T. brucei.
Methods: To
study the
complex interactions that occur at the
molecular level, the researchers modeled the interactions between 550 water molecules and 2 different types of negatively charged ions.
Our ongoing
studies demonstrate that the condensin and cohesin
complexes are key
molecular machines that organize the functional 3D genome structures.
He is a former member and chair of the Neural Oxidative Metabolism & Death and
Molecular & Cellular Substrates of
Complex Disorders
Study Sections of the National Institutes of Health.
SPOKANE, Wash. —
Molecular biologist Weihang Chai, an associate professor of medical sciences, has received a five - year $ 1.45 million grant from the National Institutes of Health to
study the potential role of the CST protein
complex in preserving genome stability.
In conclusion, our
study highlights the importance of
studying gene — gene interactions in
complex diseases and provides insights into the underlying cellular and
molecular mechanisms.
Abstract Background: Recent
molecular studies have revealed a highly
complex bacterial assembly in the canine intestinal tract.
«I believe a tremendous opportunity exists to use genetics and genomics to develop new ways to diagnose, treat and prevent equine disease,» says Schultz, a Fellow who plans to
study the
molecular basis of equine genetic disease and genomic influences on
complex diseases at the University of Minnesota.
Inspired by the
studies of her physicist father, Myers» drawings read as mappings of
complex systems, at times as tiny as
molecular structures and at others as immeasurable as space itself.