However, behavior is the most
complex phenotype because it reflects not only the functioning of the whole organism but also is dynamic and changes in response to environmental influences.
X-linked lymphoproliferative syndrome (XLP or Duncan disease) is characterized by extreme sensitivity to Epstein - Barr virus (EBV), resulting in
a complex phenotype manifested by severe or fatal infectious mononucleosis, acquired hypogammaglobulinemia and malignant lymphoma.
The team notes how the leopard
complex phenotype was rare, particularly after losing ground compared to other phenotypes.
This lack of understanding is contributed by the fact that cellular aging is
a complex phenotype to measure and comprehensive studies on aging require the application of novel experimental approaches and technological platforms.
Cancer as
a Complex Phenotype: Pattern of Cancer Distribution within and beyond the Nuclear Family PLoS Medicine — Vol 1 (3) December 2004
It also alludes to
the complex phenotypes and rare drug outcomes resulting from rare pharmacogenomic variants.
We had high hopes for SNP arrays and GWAS, but as I discussed in my previous post, sequencing at large scale is required to uncover the full scope of genetic variation underlying
complex phenotypes.
The challenge of genetic association studies — especially ones for
complex phenotypes — is confirming statistical evidence of association with a functional assay.
In the last decade, genome - wide association studies (GWAS) enabled by cheap, high - throughput SNP genotyping have identified thousands of loci that influence disease susceptibility, quantitative traits, and other
complex phenotypes.
Together, these patterns are consistent with the idea that mutations underlying severe, highly penetrant phenotypes (i.e. the NBS set) are more deleterious — and thus under stronger natural selection — than variants associated with
complex phenotypes like ARMD and PGx.
Developing zebrafish models of
complex phenotypes relevant to human brain disorders.
The Y141C knockin mutation in RDS leads to
complex phenotypes in the mouse.
The McCouch Lab investigates natural variation in rice, focusing on how it evolved, how it is distributed in both domesticated and wild species of Oryza, how it conditions
complex phenotypes, and how it can be efficiently utilized in rice improvement.
This workshop will describe the different applications and cell types that use EasySep ™ Release to highly purify immune cells with more
complex phenotypes.
A considerable amount of research reveals, however, that
complex phenotypes, such as antisocial behavior, are probably due to multiple genes acting not only independently, but also interactively.
Not exact matches
«Many diseases, especially
complex diseases, involve multiple genes, and this system could be used therapeutically to target and activate multiple genes together and rescue these disease
phenotypes,» says Albert Cheng, a graduate student in the Jaenisch lab and co-author of the Cell Research paper.
The relationship is non-linear because
phenotype, or set of observable characteristics, is determined by a
complex interplay between an organism's genes — tens of thousands of them, all influencing one another's behaviour — and its environment.
The system can yield dose - response curves for candidate drugs, screen the
phenotypes of large numbers of gene mutations, or execute
complex custom protocols for completely new experiments.
Finally, transformation may provide a general approach to the analysis of
complex heritable
phenotypes by permitting the distinction between phenotypic changes without concomitant changes in DNA and functional genetic rearrangements.
«If human organs on chips can be shown to be robust and consistently recapitulate
complex human organ physiology and disease
phenotypes in unrelated laboratories around the world, as suggested by early proof - of - concept studies, then we will see them progressively replace one animal model at a time.
«We're excited about the application of CombiGEM to probe
complex multifactorial
phenotypes, such as stem cell differentiation, cancer biology, and synthetic circuits,» Lu says.
«Our study shows that
complex parallel
phenotypes in similar environments can evolve very rapidly, repeatedly and yet via different evolutionary routes.
In the current study, the researchers looked at how a protein
complex in the cell envelope, which surrounds the cell, contributes to this heterogeneity or diversity of
phenotypes.
Allelic complexity in genes will be large, and such complexity will make the analysis of genotype -
phenotype relationships difficult, particularly in the situation of common,
complex diseases.
Bioinformatic approaches to the analysis of genetic variability and
complex genotype -
phenotype relationships will moreover include gene sequence and database analyses, measures of association of haplotypes / genotypes with
phenotype, clustering procedures, neuronal networks, fuzzy and other techniques in pattern recognition, similarity measures for discrete patterns (e.g., gene sequences, structures, functions), logistic regression methods, and a spectrum of other techniques.
As a consequence of tissue macrophage deficiency, these mice develop a
complex recessive
phenotype of osteopetrosis, central blindness, and infertility (56).
Let us begin by stating the obvious fact that all disease
phenotypes reflect the consequences of defects in a
complex genetic network operating within a dynamic environmental framework.
We'd recently published some high profile studies of AMD, cleft lip, metabolic syndromes, and other
phenotypes that demonstrated our ability to unravel common
complex disease.
My main goals are: a) to unravel the functional and anatomical connectivity of the primate prefrontal cortex circuitry within the framework of
complex cognitive tasks, b) to generate tools and techniques that allow manipulating prefrontal cortex function and therefore generate symptoms of mental disorders in behaving non-human primates, and c) to produce interventions (e.g., deep brain stimulation or local / systemic drug delivery) that allow rescuing the generated disease
phenotypes.
Coupled with the dog domestication bottleneck, this likely simplified the genetic architecture of quantitative traits, including
complex disease
phenotypes that are not fixed within breeds and were not the subject of selection for novelty.
In order to determine how
complex electrical
phenotype is achieved, we then investigated the networks of co-regulation of ion channels at the genetic and at the protein levels.
Background KeyGene's innovation platform for Genomic Breeding comprises technologies for
complex trait analysis, digital
phenotyping, and the computational design of breeding strategies.
This represents the first genetic factor outside the major histocompatibility
complex (MHC) region on chromosome 6 with significant linkage to any psoriasis - related
phenotype.
The study, integration and analysis of these data increasingly allows to unravel the genetic mechanisms and networks underlying
complex biological
phenotypes paving the way for an era of «genomic medicine,» in which new diagnostic and therapeutic approaches to common multifactorial conditions are emerging.
Complete
phenotyping of the mouse immune system by polychromatic and mass cytometry (CYTOF), thanks to a set of standardised protocols enabling isolation of viable cells from lymphoid and non-lymphoid organs (lung, skin, intestine,...) for labelling using
complex ranges of antibodies whose compatibility allows the simultaneous registration of 50 quantitative parameters at least (size, structure, specific antibodies and cell viability).
The beta - catenin / TCF4
complex imposes a crypt progenitor
phenotype on colorectal cancer cells.
A new study published today describes how a
complex genomic rearrangement causes a fascinating
phenotype in chickens.
Theoretical and empirical work is beginning to reveal that autism is associated with a
complex functional
phenotype characterized by both hypo - and hyper - connectivity of large - scale brain systems.
Reply to «A call for accurate
phenotype definition in the study of
complex disorders».
Through the generation and focused
phenotyping of prospective rat models, where gene targets have been identified through the systematic mouse
phenotyping effort, we focus our complementary analyses to conditions where the larger size and higher cognitive function of the rat is advantageous for more
complex and accurate physiological assessments.
Here we show that loss of the BLM helicase
complex suppresses FANCC
phenotypes and we confirm this interaction in cells deficient for FA complementation group I and D2 (FANCI and FANCD2) that function as part of the FA I - D2
complex, indicating that this interaction is not limited to the FA core
complex, hence demonstrating that systematic genome - wide screening approaches can be used to reveal genetic viable interactions for DNA repair defects.
«While previous DNA studies have produced evidence for bay and black horses, our study has demonstrated that the leopard
complex spotting
phenotype was also already present in ancient horses and was accurately depicted by their human contemporaries nearly 25,000 years ago.»
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Complex diseases are associated with variation in Mendelian genes: A phenome - wide study using Human
Phenotype Ontology and a population genotyped on the Exome BeadChip.
By developing a simple chemically defined culture system permitting efficient differentiation of numerous human iPS cell lines toward cells of a mature hepatic state, we now demonstrate the possibility of modeling groups of diseases of non-neuronal origin whose
phenotypes are a consequence of
complex protein dysregulation within adult cells.
One of the most daunting obstacles in biomedicine is the
complex nature of most
phenotypes (including cancer, diabetes, heart disease and some rare diseases) due to interactions between multiple genetic variants and environmental influences.
I am interested in how this variation affects the cellular and molecular
phenotypes that mediate
complex trait variation.
Carcinogenesis is a
complex process involving multiple sequential mutations, which occur randomly in the DNA of normal cells over many years, even decades, until finally specific genes are mutated and cell growth becomes out of control resulting in the full neoplastic
phenotype and often metastasis.
Whether LC (ketogenic) diets are a suitable tool for weight loss will remain an important issue for some time, as more
complex interactions between
phenotype and diet composition are identified (23).
There is evidence this disorder is a
complex hereditary trait, but attempts to identify genetic causes have been hampered by assigning an affected or normal
phenotype.
Selection based on conventional
phenotype - based EBVs or gEBVs rather than on individual
phenotypes is expected to substantially increase the rate of response for
complex traits like hip and elbow dysplasia [62,65,66].