Sentences with phrase «complex phenotypes»

These studies establish a practical platform for genome - scale screening of complex phenotypes in mammalian cells and demonstrate that RNAi can be used to expose genotype - specific sensitivities.

Developing zebrafish models of complex phenotypes relevant to human brain disorders.

We had high hopes for SNP arrays and GWAS, but as I discussed in my previous post, sequencing at large scale is required to uncover the full scope of genetic variation underlying complex phenotypes.

How different genotypes and environments produce complex phenotypes is central for genetics research.

The challenge of genetic association studies — especially ones for complex phenotypes — is confirming statistical evidence of association with a functional assay.

Together, these patterns are consistent with the idea that mutations underlying severe, highly penetrant phenotypes (i.e. the NBS set) are more deleterious — and thus under stronger natural selection — than variants associated with complex phenotypes like ARMD and PGx.

In the last decade, genome - wide association studies (GWAS) enabled by cheap, high - throughput SNP genotyping have identified thousands of loci that influence disease susceptibility, quantitative traits, and other complex phenotypes.

Our group is using bulk as well as single cell - based omics approaches for investigating mechanisms behind complex phenotypes in humans, ranging from common diseases including cancer to ageing.

The McCouch Lab investigates natural variation in rice, focusing on how it evolved, how it is distributed in both domesticated and wild species of Oryza, how it conditions complex phenotypes, and how it can be efficiently utilized in rice improvement.

The team notes how the leopard complex phenotype was rare, particularly after losing ground compared to other phenotypes.

This workshop will describe the different applications and cell types that use EasySep ™ Release to highly purify immune cells with more complex phenotypes.

However, behavior is the most complex phenotype because it reflects not only the functioning of the whole organism but also is dynamic and changes in response to environmental influences.

Undoubtedly, many (if not most) of the variants underlying complex phenotypes are located outside of the 1.5 % of our genome that codes for proteins.

The finding shows that environmental exposures can be used to uncover novel candidate genes in complex phenotypes.

The different signatures, which attest to the genetic complexity of EL, correlated with differences in the prevalence and age of onset of age - associated diseases (e.g., dementia, hypertension, and cardiovascular disease) and may help dissect this complex phenotype into subphenotypes of healthy aging.

It also alludes to the complex phenotypes and rare drug outcomes resulting from rare pharmacogenomic variants.

Like most age - related diseases, this is a complex phenotype with numerous risk factors, but there's clearly a substantial inherited component at play.

Cancer as a Complex Phenotype: Pattern of Cancer Distribution within and beyond the Nuclear Family PLoS Medicine — Vol 1 (3) December 2004

This lack of understanding is contributed by the fact that cellular aging is a complex phenotype to measure and comprehensive studies on aging require the application of novel experimental approaches and technological platforms.

«Sport performance remains a complex phenotype, and caution is needed to avoid a simplistic and overly deterministic approach to genetic testing,» it says in a report.

A considerable amount of research reveals, however, that complex phenotypes, such as antisocial behavior, are probably due to multiple genes acting not only independently, but also interactively.