Sentences with phrase «complex signaling pathways»

Protein systems, such as Ras, make up the complex signaling pathways that control whether a cell divides or, in some cases, becomes cancerous and metastasizes into other regions of the body.

Dr. Yaffe's research focuses on the biology of the complex signaling pathways that cells use to respond to DNA damage and inflammation, particularly the role of protein kinases and modular binding domains in tumor development and anti-cancer therapeutics.

These proteins interact to form complex signaling pathways that can have wide - reaching effects.

To unravel the complex signaling pathway map, the scientists used their own findings from the analysis of factors regulated up or down in the interplay between tissue and stem cells, linking them with the signaling pathways described in existing literature.

Not exact matches

In complex wound management, we think a lot about what the signaling pathways are and what factors can be involved and what kind of things we could do to improve things.

Further research showed that the signaling pathways activated during the worms» response are similar to the pathways activated when more complex animals experience fear.

The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast.

The researchers examined the crystal structure of the complex of SeV C protein and transcription factor STAT1, and found that SeV C protein inhibits the signal transduction pathway of interferon gamma.

They call this form of activation «non-ligand-dependent,» and in a complex series of biochemical and animal experiments, traced the pathway through which FER's binding to MET inside the cell sets off a cascade of cell - signaling events, all directly connected in prior research with cancer initiation, including RAC1 / PAK1 and SHP2 - ERK.

For their study, the researchers examined the Fanconi anemia signal pathway, which coordinates the complex repair of crosslinks, with the aid of genetically modified and unchanged cells.

Biology is rife with examples of modularity: the overwhelming majority of molecules in a cell is either part of an intracellular complex with modular activity, such as the ribosome, or participates in an extended (functional) module as a temporally regulated element of a relatively distinct process (e.g., signal amplification in a phosphorylation ‐ mediated signaling pathway).

The effects of mutations and other genetic changes in cancer cells play out in the complex networks of molecular interactions or «signaling pathways» involved in cell growth, proliferation, and other hallmarks of cancer biology.

The elucidation of the structure and function of this complex serves as a crucial step in the ongoing effort to identify clinically important drugs with which this important signaling pathway can be targeted.

We invite original innovative research on the rational engineering of plant systems at all levels, including proteins, protein complexes, sensors, metabolic and signalling pathways, microcompartments such as carboxysomes, subcellular compartments, cell types or tissues, as well as the engineering of novel plant hybrid species and the interactions of plants with viruses, bacteria, and other organisms.

Specifically, the new study found that TB bacterial proteins trigger an immune signaling pathway inside macrophages, where a protein complex called NFKappaB triggers a key gene to make more of microRNA - 33.

8.30 Hana Paculová CDK12 connects transcriptional regulation to DNA damage repair pathway 8.55 Karol Kaiser Wnt secretion during nervous system development 9.20 Simona Hankeová The role of Notch signaling in vasculogenesis 10.00 Coffee break 10.30 Tomáš Doležal Extracellular adenosine regulates complex host - pathogen interactions through the energy release for the immune response 10.55 Ondřej Bernatík and Igor Červenka Regulation of diverse function of Dvl by phosphorylation 11.20 Jan Ryneš Dissection of Axin interactome: rational approach for control of signaling cascades via intervention with specific protein - protein interactions 12.05 Targeting opportunities: discussion & sum - up 13.00 Lunch and departure

Systems biology is an approach to biomedical research in which scientists combine complex «omics» datasets to develop a more complete understanding of complex biological systems, such as the regulation of whole genome - level transcription, regulation of the 3D genome, the role of signaling and metabolic pathways in disease, and more.

Upon T cell receptor signaling, these cells initiate a differentiation program that includes complex changes in CD4 and CD8 expression, allowing identification of transitional intermediates in this developmental pathway.

A complex set of interactions between morphogens and their corresponding signalling pathways contributes to organizing limb growth along the dorsal - ventral, anterior - posterior and proximal - distal axes.

The epidermal growth factor receptor (EGFR) pathway is a complex signaling cascade that is involved in the development and progression of cancer.

Taken together, our results provide for the first time the evidence of the biological significance of IRF - 9 / STAT2 complex, and furnish an alternative pathway modulating the expression of IFN - stimulated genes, contributing to the diversity of IFN signaling to mediate their multiple biological properties in normal and tumor cells.

The mature ISGF3 complex serves as a transcriptional regulator in type I IFN signaling pathways by translocating into the nucleus and then binding to ISRE of certain ISGs.

Further research showed that the signaling pathways activated during the worms» response are similar to the pathways activated when animals that are more complex experience fear.

For instance, the role of LIF - gp130 - Stat3 axis in promoting ES cell proliferation is particularly well - defined [1], [3], and BMP - induced differentiation signals are inhibited by a Nanog - Smad1 protein complex [4]; crosstalk between these pathways has also been reported [5].

In this study, we report that miR - 142 efficiently recruits the APC mRNA to an RNA - induced silencing complex, activates the canonical WNT signaling pathway in an APC - suppression dependent manner, and activates the expression of miR - 150.

The full pathway is in an earlier comment here, while this is an abbreviated diagram of where leucine interacts wiith insulin / IGF -1 / mTOR signalling (mTORC1 is the mTOR complex associated with growth signalling):