Sentences with phrase «complex small molecules»

We're convinced, based on this result, that we can put together a platform that would enable on - demand assembly of complex small molecules.

Chemists at the University of Illinois, led by chemistry professor and medical doctor Martin D. Burke, built the machine to assemble complex small molecules at the click of a mouse, like a 3 - D printer at the molecular level.

A machine in University of Illinois chemistry professor Martin Burke's lab assembles complex small molecules out of simple chemical building blocks, like a 3 - D printer on the molecular level.

«Dr. Burke's research has yielded a significant advance that helps make complex small molecule synthesis more efficient, flexible and accessible,» said Miles Fabian of the National Institutes of Health's National Institute of General Medical Sciences, which partially funded the research.

Works with start - up company to navigate a complex small molecule patent landscape and develop an exclusivity proposition attractive to large pharmaceutical partners.

Not exact matches

«Small molecules» are a specific class of complex, compact chemical structures found throughout nature.

To this aim, the researchers incorporated molecules into the scaffolds that are known as the major histocompatibility complex (MHC) and that presented small peptides derived from viral proteins to T cells.

In Escherichia coli, the small ribosomal subunit has a sedimentation coefficient of 30S, and consists of a 16S RNA molecule of 1541 nucleotides complexed with 21 proteins.

One of the gene's molecular targets, for example, is a microRNA (a small noncoding RNA molecule) called let7, which in turn regulates hundreds of other genes, so the effects of Lin28a can set off a complex array of regulatory interactions.

By representing data in BioPAX, Pathway Commons is able to provide a detailed representation of a variety of biological concepts including: Biochemical reactions; gene regulatory networks; and genetic interactions; transport and catalysis events; and physical interactions involving proteins, DNA, RNA and small molecules and complexes.

Details that can be included are biochemical reactions; gene regulatory networks; genetic interactions; proteins, small molecules, DNA, RNA, complexes and their cellular locations; complex assembly and transport; post-translational protein modifications; citations; experimental evidence; and links to other databases e.g. protein sequence annotation.

Recently, the crystal structure of CXCR4 complexed with small - molecule antagonists was reported [11, 82].

Unlike generic small molecules, it is difficult to standardize such inherently complex products based on complicated manufacturing processes.

Functional regulation of cystic fibrosis transmembrane conductance regulator - containing macromolecular complexes: a small - molecule inhibitor approach.

Integral to Ronai's research are translational initiatives, including the development of SBI - 756, a small molecule that disrupts the complex that initiates protein synthesis and prevents melanoma resistance when combined with BRAF inhibition.

The mission of CBCS is to provide a state - of - the - art platform and expertise for the generation of high - quality bioactive chemical tools (small organic molecules) for applications within life science research in general and with the ultimate goal to explore complex biology.

«We're looking for small molecules that will affect very complex feedback mechanisms in the brain, but in a subtle way,» Finn said of the new project.

Jones is characterizing all the members of the SKIP complex and identifying the most promising interactions and enzyme activities to screen for inhibitory small molecules as lead candidates for cancer therapeutics.

Such a similarity makes TNFΔARE a unique model of a complex human pathology appropriate for the simoultaneous testing of novel therapeutics and small molecule inhibitors on two different pathologies.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

A structure of Eis, an enzyme that allows tuberculosis to resist an antibiotic of last resort, in complex with a small molecule (transparent) that inhibits its activity.

Ceres... provide evidence that complex organic molecules and even amino acids are ubiquitous on small bodies in the solar system and that water ice is abundant in the asteroid belt.»

Therefore, these tiny microRNAs can potentially be used to treat complex diseases as AMD without having to perform extensive screening for small molecule drugs.

«Recent spacecraft studies of Comet 67P / Churyumov - Gerasimenko with Rosetta and of [asteroid] Ceres... provide evidence that complex organic molecules and even amino acids are ubiquitous on small bodies in the solar system and that water ice is abundant in the asteroid belt.»

More recently, the team published the structure of Eis in complex with two potent inhibitors they'd discovered using high - throughput screening of approximately 123,000 small molecules.

As we already know, starch is a complex carbohydrate in the form of many small molecules that are attached to each other in large chains, which get broken down into smaller ones once they are digested for the purpose of meeting the energy needs of all cells in our bodies.

Testosterone promotes skeletal muscle anabolism (the construction of complex molecules from smaller ones)

The rest of the carbohydrates in banana are complex carbohydrate molecules, which are made up of several smaller sugar molecules bonded together to form large chains.

Anabolism, small molecules are transformed into larger, more complex molecules of carbohydrates, protein, and fat.

MBS extends the creativity and experience necessary for more complex hybridoma development projects, including small molecules and anti-idiotypic.

Proteins are large complex molecules consisting of chains of smaller building blocks called amino acids.

Execution of complex multistep syntheses of small molecules, polymers, following GLP and GMP guide lines.

MBS extends the creativity and experience necessary for more complex hybridoma development projects, including small molecules and anti-idiotypic.

MBS extends the creativity and experience necessary for more complex hybridoma development projects, including small molecules and anti-idiotypic.