Sentences with phrase «complex subunit»

The protein encoded by W01A8.1 in C. elegans is identified as Mediator Complex subunit 28 (MDT - 28) in many protein databases (e.g., Pfam, UniProt, PIR, WormPep)(accessed on March 14, 2015), but the bioinformatics analysis reveals that this is a misannotation.

Protein databases annotate W01A8.1 as Mediator Complex subunit 28, hence the official protein name assignment of MDT - 28 in WormBase (WS246).

This increased mtDNA damage results in a decrease in the abundance of mitochondrial respiratory chain complex I subunits in Polg mutator brains (Hauser et al., 2014).

Not exact matches

Crystal structures of the 30S ribosomal subunit in complex with messenger RNA and cognate transfer RNA in the A site, both in the presence and absence of the antibiotic paromomycin, have been solved at between 3.1 and 3.3 angstroms resolution.

Analysis of crosslinked complexes of M1 RNA, the catalytic RNA subunit of ribonuclease P from Escherichia coli, and transfer RNA precursor substrates has led to the identification of regions in the enzyme and in the substrate that are in close physical proximity to each other.

The study revealed that CSN6, a subunit of a protein complex known as COP9 signalsome, is overexpressed in colorectal cancer tissue samples.

The 673 - kilodalton protease complex consists of 14 copies of two different subunits, alpha and beta, forming a barrel - shaped structure of four stacked rings.

Heterotrimeric guanine nucleotide - binding regulatory proteins (G proteins) dissociate into guanosine triphosphate (GTP)- bound alpha subunits and a complex of beta and gamma subunits after interaction with receptors.

This was important because NCF1, which encodes a subunit of NOX2, is thought to be related to SLE due to its role in activating the phagocytic complex NOX2.

Using the atomic structures of the large ribosomal subunit fromHaloarcula marismortui and its complexes with two substrate analogs, we establish that the ribosome is a ribozyme and address the catalytic properties of its all - RNA active site.

In particular, there was a complex between the 40S ribosomal subunit and initiator tRNA that went away when heme was missing or double - stranded RNA was present.

The UAB study of the subunit H2A.Z in mice was the first done in a complex mammalian model.

«Telomerase is a unique protein - RNA complex where the protein subunit uses its RNA component as a template to add identical fragments of DNA to the end of chromosomes,» said Emmanuel Skordalakes, Ph.D., associate professor in the Gene Expression and Regulation program of Wistar's NCI - designated Cancer Center.

In humans, a similar protein complex called CSN and its subunit CSN6 is now believed to be a cancer - causing gene that impacts activity of another gene (Myc) tied to tumor growth.

An electrophysiological assay showed that this complex is oriented with four T1 domains facing the transmembrane pore and four β subunits facing the cytoplasm.

The assembly includes the cytoplasmic (T1) domain of the integral membrane α subunit together with the oxidoreductase β subunit in a fourfold symmetric T14β4 complex.

In Escherichia coli, the small ribosomal subunit has a sedimentation coefficient of 30S, and consists of a 16S RNA molecule of 1541 nucleotides complexed with 21 proteins.

Images produced by the study clearly show the structure of the proteasome complex — with the protein backbone of each of its 28 subunits visible along with most of the side chains of the proteins.

That gene encodes a protein called BAF 180, which is a subunit of the PBAF subtype of the SWI / SNF chromatin remodeling complex.

This structure is in complex with an oxido - reductase β subunit of the kind that can regulate mammalian Kv channels in their native cell environment.

Twelve percent encoded mitochondrial proteins such as succinate dehydrogenase complex, subunit B, iron sulfur (Ip)(τ statistic = — 0.76, P = 2.2 × 10 — 7), and ubiquinol — cytochrome c reductase subunit (τ statistic = — 0.65, P = 7.4 × 10 — 6)(Figure 1), and 6 % encoded lysosomal proteins (Supplemental Table 2, http://www.jci.org/cgi/content/full/112/12/1796/DC1).

Examples of adipose tissue transcripts whose expression correlated with body mass include (a) Csf1r and (b) CD68 antigen (Cd68), which correlated positively with body mass, (c) succinate dehydrogenase complex, subunit B, iron sulfur (Ip)(Sdhb), and (d) ubiquinol — cytochrome c reductase subunit (Uqcr), which correlated negatively with body mass.

«It becomes clear that these two complexes are not only structurally and functionally similar,» says Elena Conti, «also their regulatory subunits work in a similar manner.»

(The two alpha subunits may bind either to the proNGF dimer before cleavage or to the complex of the gamma subunit and the NGF dimer after cleavage.)

We found that genes encoding subunits of the Mg - chelatase complex and 3,8 - divinyl protochlorophyllide a 8 - vinyl reductase (DVR) likely function directly downstream of the GATAs and that DVR expression is limiting in the pale - green gnc gnl mutants.

In 1967 Silvio S. Varon and Eric M. Shooter of the Stanford University School of Medicine isolated NGF by a different procedure and found that the NGF dimer was present as a stable complex with two copies each of two other proteins, which they designated the alpha and gamma subunits.

Presenilin - 1 (PS1) or presenilin - 2 (PS2), nicastrin (NCT), anterior pharynx - defective 1 (Aph - 1), and presenilin enhancer - 2 (Pen - 2) have been considered the minimal essential subunits required to form an active γ - secretase complex.

XPD encodes one of the two helicase components of basal transcription / DNA repair factor IIH (TFIIH), a ten - subunit, multifunctional complex that is essential for multiple processes, including basal transcription initiation and DNA damage repair via the nucleotide excision repair (NER) pathway [6,7].

The SMARCA4 encodes a catalytic ATPase subunit of the SWI / SNF chromatin remodeling complex.

We subsequently determined that expression of the SMARCA2 protein, another catalytic subunit of this complex, is also lost in all of these tumors.

Proper transfer of V1 complexes or subunits from the membrane to the cytoplasm and back appears to require not only phosphorylation events, conformational changes in the V1VO holoenzyme, the V1 complex and the V1 subunit C, but also the temporary interaction with protein kinase A, cytoskeletal elements, the heterotrimeric protein complex RAVE and the glycolytic enzyme aldolase.

Initially, the subset of members interacting with NR1, the obligatory subunit of all functional NMDA receptor complexes [57], was identified using the Human Interactome Map (HiMAP) database.

These cells were immortalized by retroviral transduction of the SV40 T antigen and Telomerase reverse transcriptase (TERT), the catalytic subunit of the telomerase complex [4], and then termed HMLE (Human Mammary with Large T and TERT).

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation.

Focus of this project is the CaaX processing microcompartment transiently formed at the ER, which is required for the modification of yeast Chs4, a regulatory subunit of the chitin synthase (CHS) III complex.

No one knew if this tail — also known as the C - terminus of the alpha subunit — touches anything else in the core of the RNA polymerase complex.

All muscle fibers exhibit complex II immunoreactivity, consistent with the nuclear DNA - encoded expression pattern of this and all other subunits of complex II.

van der Lee R, Szklarczyk R, Smeitink J, Smeets HJ, Huynen MA, Vogel R. Transcriptome analysis of complex I - deficient patients reveals distinct expression programs for subunits and assembly factors of the oxidative phosphorylation system.

Martin Schwickart (Zachariae, MPG)-- «Molecular analysis of novel subunits of the anaphase - promoting complex (APC / C) in yeast» (2005)

In Situ Localization of N and C Termini of Subunits of the Flagellar Nexin - Dynein Regulatory Complex (N - DRC) Using SNAP Tag and Cryo - electron Tomography.

Moreover, DDX3 is identified as a subunit of mammalian Mediator complex (9) and has a transcriptional activation function (1).

Hargreaves brings her knowledge of biochemistry and epigenetic regulation to investigate a subunit of the SWI / SNF complex called ARID1A, which is mutated in many solid tumors, such as in ovarian, bladder and colorectal cancers.

HAUS, the 8 - subunit human Augmin complex, regulates centrosome and spindle integrity.

While studying the basic function of the IKK complex in zebrafish and mice, researchers at the Salk Institute for Biological Studies discovered that one subunit reigns in the activity of the other instead of boosting it, as was widely believed before.

The SWI / SNF complex is polymorphic, meaning that the complex can assume different forms through various combinations of individual subunits.

The culprit is one of the two subunits that make up the IKK protein complex, which is known to regulate several biological processes including inflammation.

The peptoid was not complicated — just a string of two repeating chemical subunits (think «ABABAB»)-- yet complex because it was a dozen subunits long.

The restoration of the ETS structure and function was confirmed by in - gel activity assay of complex I, which demonstrated an increase in activity to 30 — 40 % of that in WT cells in cybrids transfected by constructs containing all three modifications; it was also supported by the «marked» increase in levels of COX2 and ND6, both of which are mitochondrially - encoded ETS subunit component proteins.

They exist in a complex made of three related subunit proteins: Gα, Gβ, and Gγ.