Not exact matches
New research led by Li Ding, Ph.D.,
of Washington University School
of Medicine in St. Louis, shows that current approaches to genome analysis systematically miss detecting a certain
type of complex mutation in cancer patients» tumors.
«We call this
type of mutation a
complex indel because insertion and deletion is happening at the same time, in the same genomic location,» Ding said.
'' [
Type 1 diabetes] is clearly is one
of these
complex genetic disorders,» involving
mutations in several genes acting in concert to predispose someone to the condition, says Hakon Hakonarson, director
of The Children's Hospital
of Philadelphia's Center for Applied Genomics and lead author
of the new study, published this week in the online edition
of Nature.