Sentences with phrase «complexes in gene expression»

Her research at UMMS and HHMI encompassed an array of topics related to the role of RNA and RNA - protein (RNP) complexes in gene expression.

Not exact matches

Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice

Scientists have shifted from studying single molecules to investigating large complexes of interacting biological macromolecules involved in processes such as metabolic pathways, gene expression, and development of disease.

«Single - nucleus RNA sequencing, droplet by droplet: DroNc - Seq, technology that merges single - nucleus RNA sequencing with microfluidics, brings new scale to gene expression studies in complex tissues.»

Trithorax - like group complex containing KDM6A acts antagonistically to Polycomb - repressive complex 2 (PRC2) containing EZH2 in maintaining the dynamics of the repression and activation of gene expression through H3K27 methylation.

«Telomerase is a unique protein - RNA complex where the protein subunit uses its RNA component as a template to add identical fragments of DNA to the end of chromosomes,» said Emmanuel Skordalakes, Ph.D., associate professor in the Gene Expression and Regulation program of Wistar's NCI - designated Cancer Center.

Clicking through 5000 hypertext links on the site's 1500 pages, visitors can trace the complex web of gene expression and protein action that transforms the fruit fly from a one - celled embryo into a six - legged adult, exactly as the saga unfolds in real - life flies.

MEGENA (for Multiscale Embedded Gene Co-expression Network Analysis) projects gene expression data onto a three dimensional sphere, allowing scientists to study hierarchical organization patterns in complex networks that are characteristic of diseases such as cancer, obesity, and AlzheimeGene Co-expression Network Analysis) projects gene expression data onto a three dimensional sphere, allowing scientists to study hierarchical organization patterns in complex networks that are characteristic of diseases such as cancer, obesity, and Alzheimegene expression data onto a three dimensional sphere, allowing scientists to study hierarchical organization patterns in complex networks that are characteristic of diseases such as cancer, obesity, and Alzheimer's.

The modern study of gene regulation started in the 1950s, but researchers only started to unravel the complex array of histone modifications that fine - tune chromatin control of gene expression 20 years ago.

«By looking comprehensively at gene expression within cells, we can now spot numerous important differences in complex tissues like the brain that are invisible today,» said George Church, Ph.D., a Core Faculty member at the Wyss Institute and Professor of Genetics at Harvard Medical School.

«Our hypothesis is that structures conserved in RNA are like a common template for regulating gene expression in mammals — and that this could even be extrapolated to vertebrates and less complex organisms.»

An analysis of all gene transcription in the cultured cell lines turned up a large gene complex in which gene expression differed conspicuously in cells from patients compared to controls.

«We found dysregulated expression in a suspect gene complex which adds to evidence that PMDD is a disorder of cellular response to estrogen and progesterone,» explained Peter Schmidt, M.D. of the NIH's National Institute of Mental Health, Behavioral Endocrinology Branch.

We found that genes encoding subunits of the Mg - chelatase complex and 3,8 - divinyl protochlorophyllide a 8 - vinyl reductase (DVR) likely function directly downstream of the GATAs and that DVR expression is limiting in the pale - green gnc gnl mutants.

He studies how structural changes to chromosomes impact gene expression and cell fate with a focus telomere, telomerase, and chromosomal stability, epigenetic proteins, and the role of the SOSS complex in DNA damage repair.

Now researchers at UC San Francisco have taken the first step toward a comprehensive atlas of gene expression in cells across the developing human brain, making available new insights into how specific cells and gene networks contribute to building this most complex of organs, and serving as a resource for researchers around the world to study the interplay between these genetic programs and neurodevelopmental disorders such as autism, intellectual disability and schizophrenia.

At any given instant it can be argued that the cell is in a «state» defined by its components — their concentrations and locations, the interactions between components — that are modulated in space and time, and the complex circuitry — that involves a large number of interacting networks and a snapshot of the dynamical processes — such as gene expression, cell cycle, transport of components, etc..

Further, his group pioneered expression quantitative trait locus (eQTL) studies, which enabled variation in global gene expression to be applied to genetics of complex human diseases.

Abnormalities in mitochondrial genes, gene expression and gene function in inherited and complex diseases, like neuromuscular disorders, neurological syndromes and cardiomyopathies, in human patients and animal models, but alos in therapy - predictions (radiotherapy).

We observed that in the majority of tissues there are many genes that display expression profiles that are more complex than simple monotonic changes with PMI.

In bacteria, the ligand - PBP complex develops high affinity for transmembrane proteins such as Trg, and the chimeric Trg - HK protein allows activation of gene expression with one additional protein, a bacterial response regulator [5].

These results suggest that inhibition of mTOR - raptor complex or silencing mTOR gene expression induced cell cycle arrest at G1 phase in ALK + ALCL cells.

Upon salt - stress treatment, Arabidopsis mobilizes a complex set of pathways that includes alterations in the regulation of gene expression and metabolic adjustments that attempt to establish a new

The idea behind our work in bioinformatics is to build on existing methodologies regarding large - scale data analysis and to develop novel algorithms for processing and merging complex biological data from multiple sources such as gene expression data, sequence information, protein - to - protein interaction data, clinico - pathological data etc..

The isoforms of this histone play complex regulatory roles in several cellular processes — epigenetic regulation of gene expression, selective regulation of developmental genes, and telomere maintenance — that could contributed to tumor growth and progression if dysregulated.

Others were unanticipated, including significant differences in expression levels among genes involved in fundamental cellular processes such as ribosomal biogenesis, transfer RNA processing, and Notch - signaling — part of a complex system of communication that governs basic cellular activities and coordinates cell actions.

Crystal structure of a Cas9 in complex with an RNA guide and a stretch of target DNAWIKIMEDIA, H. NISHIMASU ET AL.. A team of researchers at the Gladstone Institutes in San Francisco, California, has used a version of CRISPR gene editing known as CRISPR interference (CRISPRi) to reversibly and accurately suppress gene expression in induced pluripotent stem cells (iPSCs) and derivative T cells and heart cells, according to a study published in Cell Stem Cell today (March 10).

Bach1 is a member of the BTB and CNC transcriptional regulator family that, like Nrf2, binds to ARE sequences as heterodimeric complexes with small Maf proteins [18] A major physiological role for Bach1 is in iron homeostasis through regulation of the expression of heme oxygenase - 1 (HMOX1), ferroportin (FPN1) and Ferritin (FTH) genes [23], [24], [33], [41].

These methods integrate single - cell experiments and discrete stochastic analysis to predict complex gene expression and signaling behaviors in Saccharomyces cerevisiae — or yeast, a scientific - lab standard since yeast and human cells share many genes.

The Sarma laboratory is interested in the mechanisms of epigenetic gene regulation, or how the dynamic modifications of the architecture of chromatin, the complex of DNA and proteins within the nucleus of our cells, impacts gene expression and cellular function.

For custom gene expression projects the Genomics Core has a platform that uses sets of human and mouse custom arrays whose probe content is aimed at gene expression studies in the areas of cancer, immunology and other complex diseases.

Taken together, our results provide for the first time the evidence of the biological significance of IRF - 9 / STAT2 complex, and furnish an alternative pathway modulating the expression of IFN - stimulated genes, contributing to the diversity of IFN signaling to mediate their multiple biological properties in normal and tumor cells.

Understanding the metabolism and gene expression profiles as well as inter-species interactions within these complex microbial communities are necessary steps in studying the diseases and finding new treatment solutions.

Our results reveal the regulatory mechanisms that interplay to drive transcription factor occupancy, chromatin state, and gene expression in complex mammalian cell states.

These findings provide new insights into how chromatin regulation modulates stochastic gene expression and transcriptional bursting, with implications for regulation of pluripotency and development.Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription.

Since regeneration recapitulates in broad strokes embryonic development, during which a complex multi-cellular organism develops from a handful of embryonic stem cells, the researchers began by comparing gene expression patterns between the two processes.

We find that Polycomb repressive complex - active genes have greater cell - to - cell variation in expression than active genes, and these results are validated by knockout experiments.

Cyanobacteria possess one of the simplest known circadian clocks — the KaiABC system, a complex of proteins that undergoes a 24 - hour biochemical cycle, which triggers oscillations in gene expression and physiological activity.

This complex plays a key role in the RNA interference (RNAi) pathway that silences gene expression.

In this work, we have analyzed at blastocyst stage the expression of some genes that are modifiers of epigenetic gene silencing that produce considerable variance in many complex traits in inbred individuals reared in controlled environments [39, 40In this work, we have analyzed at blastocyst stage the expression of some genes that are modifiers of epigenetic gene silencing that produce considerable variance in many complex traits in inbred individuals reared in controlled environments [39, 40in many complex traits in inbred individuals reared in controlled environments [39, 40in inbred individuals reared in controlled environments [39, 40in controlled environments [39, 40].