Sentences with phrase «component of this pathway»
The second component of the pathway occurs after the target is reached.
link.springer.com
Over the past several years, researchers in the lab of Whitehead Member David Sabatini have been identifying the many key components of the pathway — whose deregulation is associated with diseases ranging from diabetes to cancer to epilepsy — moving ever closer to finding precisely how mTORC1 actually senses the presence of amino acids.
«We had been studying components of this pathway for several years,» said senior author Dr. Andrea Ballabio, professor of molecular and human genetics at Baylor College of Medicine and Texas Children's Hospital in Houston, Texas, and director of the Telethon Institute of Genetics and Medicine in Naples, Italy.
As new components of the pathway are identified and their roles elucidated, the number of potential targets that could be manipulated therapeutically increases.
Today, the lin - 28 pathway is a main focus in the Sliz laboratory, where structural studies of other components of the pathway are underway.
The third component of the Pathways Pilot Project is «the evaluation of the Articling and Law Practice Program in order to gather evidence - based information on the application and results of the two pathways».
In 2013, the Department of Education of the Archdiocese of New York launched Regionalization, a key component of Pathways to Excellence, our strategic plan designed to ensure a vibrant, sustainable Catholic elementary school system in the Archdiocese of New York, both now and in the future.
Pathways involved in cellular metabolism typically regulate themselves, meaning that some components of the pathway control each other's activities.
«Two components of the pathway, the phosphatase PTPD2 and the lipid PA, are together required for HER2 signaling to function in mammary epithelial cells.»
We mapped the components of the pathway and everything turned out to be more exciting than we could have hoped for.
The translational relevance of this study is supported by the analysis of human prostate cancer samples that showed upregulation of these three components of the pathway, which correlated with enhanced mTORC1 activation.