However, higher rates of
a composite outcome of perinatal morbidity and mortality were seen for nulliparous women having homebirths (adjusted odds ratio 1.75; 95 % CI, 1.07 — 2.86), with no differences for multiparous women.
Most studies of homebirth in other countries have found no statistically significant differences in perinatal outcomes between home and hospital births for women at low risk of complications.36, 37,39 However, a recent study in the United States showed poorer neonatal outcomes for births occurring at home or in birth centres.40 A meta - analysis in the same year demonstrated higher perinatal mortality associated with homebirth41 but has been strongly criticised on methodological grounds.5, 42 The Birthplace in England study, 43 the largest prospective cohort study on place of birth for women at low risk of complications, analysed
a composite outcome, which included stillbirth and early neonatal death among other serious morbidity.
AHI was associated with
the composite outcome when analyzed by itself.
The researchers found that, after adjusting for potentially confounding factors, time spent with oxygen saturation < 90 %, sleep time, number of awakenings, periodic leg movements, heart rate, and daytime sleepiness were all associated with
the composite outcome, with the total sleep time spent with oxygen saturation below 90 % being the strongest association (9 minutes vs. 0 minutes: hazard ratio = 1.5, 95 % confidence interval, 1.25 - 1.79).
The patients were followed up through provincial health administrative data (Ontario, Canada) until May 2011 for CV disease (myocardial infarction, stroke, congestive heart failure, revascularization procedures) and death from any cause, analyzed as
a composite outcome.
However, after the other OSA - related factors were added to the model, AHI was no longer a significant predictor of
the composite outcome.
The efficacy of statin treatment was analysed on
the composite outcome of Major Cardiovascular Events (MACE), defined as all cause mortality, non-fatal myocardial infarction and non-fatal stroke.
Patients of high - volume surgeons (75th percentile of yearly mesh - based procedures) had a significantly lower risk for experiencing
the composite outcome (surgical procedures related to removal or revision of mesh slings).
The researchers found that the addition of vitamin D3 to ciclesonide did not significantly reduce the rate of first treatment failure (
a composite outcome of decline in lung function and increases in use of beta - agonists, systemic steroids, and health care utilization) compared with placebo; 28 percent and 29 percent of participants in each group, respectively, experienced at least 1 treatment failure during 28 weeks.
Compared with potassium excretion of less than 1.5 grams per day, higher potassium excretion was associated with reduced risk of
the composite outcome.
The association between salt intake as estimated by twenty - four - hour urinary sodium excretion and
the composite outcome of death and serious cardiovascular events was assessed over a median of 4.2 years for both groups of subjects.
Adjusting for potassium intake reduced the risk of
the composite outcome somewhat for both high and low sodium intakes.
Peterson et al. (2006a, b) also found confronting, self - control and accepting responsibility were positively associated with infertility - specific stress, whilst Terry and Hynes (1998) identified emotional approach as positively linked to their depression / anxiety
composite outcome measure.
Not exact matches
But Whitehead upholds such perplexities by his conviction that recognition of a thing as a
composite and also as a unity are required modes of understanding, that these two modes are reciprocal, that they presuppose each other, and that the perspective emphasizing the
composite exhibits an
outcome and the perspective emphasizing the unity exhibits a causal factor (MT 63).
In addition, although many of the
outcomes included in the
composite are likely to reflect problems which occur during labour and birth, their long term implications for the baby are uncertain.
Main
outcome measure A
composite primary
outcome of perinatal mortality and intrapartum related neonatal morbidities (stillbirth after start of care in labour, early neonatal death, neonatal encephalopathy, meconium aspiration syndrome, brachial plexus injury, fractured humerus, or fractured clavicle) was used to compare
outcomes by planned place of birth at the start of care in labour (at home, freestanding midwifery units, alongside midwifery units, and obstetric units).
There was no difference overall between birth settings in the incidence of the primary
outcome (
composite of perinatal mortality and intrapartum related neonatal morbidities), but there was a significant excess of the primary
outcome in births planned at home compared with those planned in obstetric units in the restricted group of women without complicating conditions at the start of care in labour.
The primary
outcome was a
composite of perinatal mortality and specific neonatal morbidities: stillbirth after the start of care in labour, early neonatal death, neonatal encephalopathy, meconium aspiration syndrome, brachial plexus injury, fractured humerus, and fractured clavicle.13 This
composite measure was designed to capture
outcomes that may be related to the quality of intrapartum care, including morbidities associated with intrapartum asphyxia and birth trauma.
Panel A shows a
composite neonatal
outcome (fetal death, infant death, a 5 - minute Apgar score of less than 4, or neonatal seizures) in subgroups defined according to maternal characteristics.
We considered a range of prespecified maternal, fetal, and neonatal
outcomes, including fetal death, neonatal death (defined as death during the first 28 days after birth), perinatal death (a
composite of fetal and neonatal deaths), and infant death (defined as death during the first year of life).
Association between Planned Out - of - Hospital Birth and a
Composite Neonatal
Outcome and Cesarean Delivery, According to Subgroups.
To assess the robustness of the results of our regression analysis, we performed covariate adjustment with derived propensity scores to calculate the absolute risk difference (details are provided in the Supplementary Appendix, available with the full text of this article at NEJM.org).14, 15 To calculate the adjusted absolute risk difference, we used predictive margins and G - computation (i.e., regression - model — based
outcome prediction in both exposure settings: planned in - hospital and planned out - of - hospital birth).16, 17 Finally, we conducted post hoc analyses to assess associations between planned out - of - hospital birth and
outcomes (cesarean delivery and a
composite of perinatal morbidity and mortality), which were stratified according to parity, maternal age, maternal education, and risk level.
The definition of low risk used in the cohort study was based on criteria contained in the NICE Intrapartum Care Guidelines.11 The primary clinical
outcome was a
composite measure of adverse perinatal
outcomes encompassing perinatal mortality and specified neonatal morbidities (box).
The main
outcome measures were behavioural or physiological indicators and
composite pain scores, as well as other clinically important
outcomes reported by the authors of included studies.
The
outcome is a complex, multi-level, continuously re-negotiated,
composite political identity, which can express itself through local, regional, or «national» narratives.
The primary
outcome, a
composite of postoperative complications and death at 30 days following surgery, was met by 36.6 percent of patients in the intervention group and by 43.4 percent in the usual care group.
These
outcomes were perinatal mortality and a
composite of neonatal morbidity (defined as neonatal intensive care admission, sepsis, meconium aspiration, necrotizing enterocolitis, respiratory distress syndrome or intraventricular hemorrhage).
The study's primary limitation is that the sample was not large enough to detect differences in the components of the primary endpoint, only a
composite of these
outcomes.
All - cause mortality and hospitalization for heart failure were tracked as a
composite primary
outcome.
Here are the key details: Population = 1,755 institutionalised and community - dwelling Spanish people (985 females and 770 males), aged > 65 years Intervention = four different measurements of strength (grip, shoulder abduction, hip flexion and knee extension) using a hand dynamometer, compiled into a
composite measure Comparisons = four quartiles of strength (high, medium - high, medium - low, and low)
Outcome = risk ratios for mortality and hospitalisation To combine the four measurements of strength into one
composite measure, the researchers used the following calculation.
Researchers used
composite achievement results from the 2012 Programme for International Student Assessment, or PISA, as the performance metric, and weighed those scores against 63 «inputs,» or factors that could influence educational
outcomes, such as teaching materials and technology, the quality of school buildings, and teacher training.
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The
composite county rank is based on an index that is made up of the following six
outcome measures:
The primary
outcome was a
composite index providing two scales representing negative parenting and supportive parenting measured at baseline and 9 months.
The multiple sclerosis functional
composite measure (MSFC): an integrated approach to MS clinical
outcome assessment
In the Federal Child and Family Services Reviews, placement stability is one of the four
composites used as the basis for national standards for Permanency
Outcome 1: Children have permanency and stability in their living situations.
Main
Outcome Measures Lifetime DSM - IV disorders were assessed with the World Mental Health (WMH) Survey Initiative version of the World Health Organization
Composite International Diagnostic Interview (WMH - CIDI), a fully structured interview designed to be administered by trained lay interviewers.
Outcome composites reflected positive (social competence, health - promoting behavior, self - esteem) and negative (externalizing, internalizing, academic problems) developmental
outcomes.
The main
outcome was depression (denoting the entire range of depressive symptoms, including normal sadness in response to loss, as well as chronic depressed emotional affect and clinical depression meeting criteria for psychiatric disorder) measured by a separate scale or as part of a
composite measure.
The
outcomes were measured with
composite variables computed as a mean of at least two scales.
Although it is instructive to examine various different dimensions of parenting for associations with child health and health behaviours, it may also be useful to consider how a single
composite measure of positive parenting is associated with health
outcomes.
The report examined associations between these individual measures or «dimensions» of parenting and health, as well as looking at associations between health
outcomes and a
composite measure or «index» of parenting.
Multiple regression analyses were used to further explore possible mediator or suppressor effects of the working alliance on
outcome variables (residual change in IES - R
composite score and residual change in BSI anxiety and BSI depression).
The two variables were not significantly correlated (r =.093, p =.26), which justified using them as separate
outcomes rather than as a
composite variable.
Results of these analyses yielded few significant associations with parenting
outcomes in either the SB or CG, as was the case when the parental
composite FES variable was utilized.
Other
composite measures of caring activity by the father at 9 months, 3 years or 5 years were not associated with child behavioural
outcomes.
The interaction term was significant only for two
outcomes at post-test (results not shown): the
composite measure of determinants within the domains of alcohol and breakfast.
Main
Outcome Measures The DSM - IV disorders, severity, and treatment were assessed with the WMH version of the WHO
Composite International Diagnostic Interview (WMH - CIDI), a fully structured, lay - administered psychiatric diagnostic interview.
Previous MCS studies have related broad
composite measures of father engagement in caring activities to subsequent child behavioural
outcomes using subscales of total difficulties (emotion, conduct, attention or peer problems)[38 — 40]: most effects were very small and not statistically significant, but (among the large number of analyses performed), inverse associations were reported for (a) engagement at 9 months with emotional problems at 3 years [38], (b) engagement at 3 years with attention problems at 5 years [39] and (c) engagement at 5 years with peer problems at 7 years [40].