Sentences with phrase «compound libraries»
Compound libraries refer to a collection of different molecules or chemicals that have been carefully prepared and stored. These libraries are used by scientists to search for new drugs or substances that can be used for various purposes like healing diseases or conducting experiments. Full definition
To do that, large compounds libraries are tested on a biological model showing a specific therapeutic target.
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Screen novel chemical compound libraries to identify effective drugs to treat active disease.
The partnership will give Swedish academic researchers access to AstraZeneca's annotated small molecule compound library with the aim of identifying novel protein targets aligned to key unmet medical needs.
Our studies and others have shown that screening of compound libraries for small - molecule effectors offer a powerful method for generating research tools.
The course gives a broad introduction to high throughput screening (HTS) that is technique used to identify biologically active small organic molecules through screening of compound libraries with the help of robust test systems and advanced instrumentation.
The self - renewable capacity of these cells, their ability to differentiate into several tissue progenitors (neural, mesenchymal stem cells...), and the possibility to work with mutated cell lines define human stem cells as a good basis for screening compounds libraries in order to discover new potential drugs for monogenic diseases.
«After screening a natural compound library, we developed an unbiased look at combinations of nutrients that have a better effect on prostate cancer than existing drugs,» says corresponding author Stefano Tiziani, assistant professor in the Department of Nutritional Sciences and Dell Pediatric Research Institute at UT Austin.
Companies in the partnership supply compound libraries and drug discovery expertise to the effort, while academic partners contribute knowledge about the disease and facilities for screens and assays.
By screening a virtual compound library for chemicals that could fit inside this pocket, using state - of - the - art computer software, they identified a drug candidate that potently inhibits Bcl3.
Scientists at the Centers for Disease Control and Prevention (CDC) also contributed by performing initial screening of the Gilead Sciences compound library to find molecules with promising antiviral activity.
PsychoGenics leverages its sophisticated Cube technology platforms and broad capabilities to partner with pharmaceutical, biotechnology and not - for - profit research entities to screen diverse compound libraries and discover valuable new therapies for the CNS market.
By early next year, the assay core at Gladstone plans to obtain specialized compound libraries for select high - throughput screening in - house.
(A) Human lung fibroblast cells were plated in 384 - well Optilux plates and screened with compound libraries at 15 µM for 18 hours.
Interestingly, Slaoui said the efforts of the Shanghai center will build on ongoing work in neural stem cell research and natural product compound libraries, which presumably means traditional Chinese medicines.
In each iteration, one or more baits are individually coupled to up to 8000 fragments to generate a custom - made compound library that can be screened in any plate - based assay.
The team screened a small molecule compound library and identify a drug, which they call CLP257.
Dr. Zeng is collaborating with the NIH in a project that would involve the use of a large compound library in the screening efforts.
Then candidate substances, culled from chemical compound libraries, are dropped onto the receptors, and scientists look for evidence of a reaction.
«Companies have amassed large — and in some cases very high quality — compound libraries,» says Lee Flippin, senior director of medicinal chemistry at FibroGen.
In one case, the researchers screened a small - molecule compound library and identified compounds that bind tightly to NUCB1, an otherwise little - known protein that showed strong interactions with the arachidonoyl probes.
To identify new high - affinity CFTR inhibitors, a large, diverse small - molecule compound library was screened using a cell - based fluorescence assay developed previously in the lab.
Such projects involve developing and optimizing assays for automation, screening a large compound library, and characterizing each small - molecule probe.
After developing and optimizing assays in - house, Gladstone scientists can transfer these assays to the SMDC or other external facilities to perform high - throughput screening with large compound libraries to identify potential drugs that may lead to therapies.
The PubChem (Kim et al., 2016) compound library (more than 80 million molecules) was compared with ponatinib to filter all molecules which are at least 60 % similar to this compound (10,655,787 molecules).
The RC is equally determined that technological platforms, and optimized, responsive resources (compound libraries, databases, biological resources) are available for its talented scientists.
Towards that goal, the Foundation invested heavily in essential drug discovery assets like animal models and in vitro systems to screen existing drugs and compound libraries.
Quantitative structure - activity relationship studies and compound library screening experiments are guiding improvements in binding affinity.