Sentences with phrase «compound library screening»

Not exact matches

David Sinclair of Harvard Medical School in Boston and colleagues at the biotech firm BIOMOL Research Laboratories in Plymouth Meeting, Pennsylvania, screened a library of compounds for molecules that trigger SIRT1 activity.

In this study, the researchers screened a library of 200,000 small molecule compounds to identify potential inhibitors of Ebola virus RNA synthesis.

In 1998, for example, Wiman's team screened a library of 2000 compounds from the U.S. National Cancer Institute and found two that appeared to restore mutant p53's ability to kill cancer cells.

To find new compounds for spraying and nets, IVCC has partnered with several large chemical companies including BASF, Syngenta, and Sumitomo to screen more than 4 million compounds in their libraries.

This work began as part of a biodefense grant from the National Institutes of Health, screening a library of 30,000 compounds for activity against the envelope of Nipah virus, an emerging infection first identified in 1999 in Malaysia.

When researchers screened a library of more than 200 drugs and related compounds for activity against embryonal subtype tumor cells from three patients, the most promising results involved drugs that increased oxidative stress in tumor cells.

Companies in the partnership supply compound libraries and drug discovery expertise to the effort, while academic partners contribute knowledge about the disease and facilities for screens and assays.

I first used computers to screen through a library of almost half a million compounds and reduce that to a top 237.

As part of drug discovery, one of the earlier stages is you take a huge library of chemical compounds and you screen them with an assay for malaria or TB and you see if that chemical compound kills the parasite or bacteria.

«It will allow us to screen libraries of drug compounds relatively quickly.

Specifically, the research team used a miniaturized, high - speed technology to screen through sample libraries of 2,816 compounds already approved by the US Food and Drug Administration for other uses.

«After screening a natural compound library, we developed an unbiased look at combinations of nutrients that have a better effect on prostate cancer than existing drugs,» says corresponding author Stefano Tiziani, assistant professor in the Department of Nutritional Sciences and Dell Pediatric Research Institute at UT Austin.

Typically, pharmaceutical scientists start the discovery process by «screening» large libraries of chemical compounds in search of one or a few that might treat disease.

The scientists started with a phenotypic screen, testing their library of compounds for the ability to make young fat cells mature faster and store more fat.

In one case, the researchers screened a small - molecule compound library and identified compounds that bind tightly to NUCB1, an otherwise little - known protein that showed strong interactions with the arachidonoyl probes.

Seeking to exploit this weakness and develop a new class of antifungals, an international group of researchers screened a synthetic drug library for compounds that target the synthesis of fungal but not mammalian GlcCer.

«When you're screening a set of 30 million compounds, you don't necessarily need a very high reliability with your model — you're just getting a ballpark idea about the top 5 or 10 percent of that virtual library.

Such projects involve developing and optimizing assays for automation, screening a large compound library, and characterizing each small - molecule probe.

Scientists at the Centers for Disease Control and Prevention (CDC) also contributed by performing initial screening of the Gilead Sciences compound library to find molecules with promising antiviral activity.

«We're now working with our colleagues in Sanford - Burnham's Conrad Prebys Center for Chemical Genomics to screen a large chemical library — a collection of around 300,000 compounds — to find molecules that bind to these newly discovered HNF - 4α sites,» Rastinejad said.

The MSC is a core facility providing the use of high throughput screening technology (HTS), as well as expertise and reagents, necessary for the screening of the library of small molecules for biologically active compounds in a variety of readout systems.

PsychoGenics leverages its sophisticated Cube technology platforms and broad capabilities to partner with pharmaceutical, biotechnology and not - for - profit research entities to screen diverse compound libraries and discover valuable new therapies for the CNS market.

It has assembled an extensive library of commercially available compounds and natural products that can be screened in seconds using its proprietary Avalanche tool to jumpstart its drug discovery programs.

Dr. Zeng is collaborating with the NIH in a project that would involve the use of a large compound library in the screening efforts.

The course gives a broad introduction to high throughput screening (HTS) that is technique used to identify biologically active small organic molecules through screening of compound libraries with the help of robust test systems and advanced instrumentation.

Using the predicted conformations of CXCR4, libraries of compounds have been screened to identify new antagonists [103].

Screen novel chemical compound libraries to identify effective drugs to treat active disease.

The self - renewable capacity of these cells, their ability to differentiate into several tissue progenitors (neural, mesenchymal stem cells...), and the possibility to work with mutated cell lines define human stem cells as a good basis for screening compounds libraries in order to discover new potential drugs for monogenic diseases.

By early next year, the assay core at Gladstone plans to obtain specialized compound libraries for select high - throughput screening in - house.

The second area is pharmacology based on automated screening of large libraries of compounds with therapeutic potential, following modeling of molecular mechanisms associated with diseases, as revealed by the study of pluripotent stem cells from affected donors.

Used in experiments to understand biological processes and diseases and as part of the initial drug - discovery process, Tocris life science reagents include receptor ligands, ion channel modulators, enzyme inhibitors, caged compounds, fluorescent probes, and screening libraries.

After developing and optimizing assays in - house, Gladstone scientists can transfer these assays to the SMDC or other external facilities to perform high - throughput screening with large compound libraries to identify potential drugs that may lead to therapies.

The Hub team is eager to screen the library against many diseases, with initial plans to use L1000, PRISM, Cell Painting, and other assays to find compounds with anticancer activity; the results will be posted to the Repurposing Hub website when ready.

The bioactivity of the compounds in this library and the ready availability of individual compounds identified as hits for follow - up studies make this library ideal for pilot screenings.

Towards that goal, the Foundation invested heavily in essential drug discovery assets like animal models and in vitro systems to screen existing drugs and compound libraries.

The team screened a small molecule compound library and identify a drug, which they call CLP257.