Not exact matches
In tests, they found that the new
compounds have three
modes of action.
The researchers were surprised by the
compounds» shared
mode of action because unlike the small sized TDA, polyether
compounds are quite large.
As David Yáñez, a CSIC researcher at the Zaidin Experimental Research Centre in Granada (southern Spain) explains, «Up until now, no - one had described the
mode of action of a
compound which can repeatedly reduce (by 30 %) methane production in animals without any risks, either to the animal's health, or to their productivity.»
In order to prioritize these hits
compounds for the development
of probe or lead molecules it is critical to determine their
mode of action, i.e. the biological target protein.
I then considered that drug repurposing would be a better approach to identify
compounds that can be used to treat jet lag, as the toxicity and
mode of action of existing drugs would have already been investigated.»
«Many
of the carcinogens present in mainstream smoke are known to exert their effects through a genotoxic
mode of action, which is based on their ability to induce DNA damage and mutations, although an epigenetic
mode of action, e.g., through aberrant DNA methylation and histone modifications, is also beginning to emerge for a few
of these carcinogenic
compounds.»
This is
compounded by the lower resolution
of the
mode, but it's certainly better than nothing, and the opportunities presented by this speed
of video are simply amazing... if you can catch the
action, that is.