Sentences with phrase «compounded by the large amounts»

This has been compounded by the large amounts of groundwater and surface water that have been extracted over the years for use by industry, agriculture and communities.

Not exact matches

And thanks to the compounded interest, he argues, that payment is likely to be much larger than what they would have gotten by putting a comparable amount of cash into an annuity — a common strategy among income - seeking retirees.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Large amounts of nitrogen oxide compounds are produced in particular by intensive lightning over land.

The research group, led by molecular biologist Eran Pichersky of the University of Michigan, Ann Arbor, studied two model organisms that are easily manipulated in the laboratory: basil, which produces large amounts of eugenol, and the petunia flower, whose scent is caused by three aromatic compounds including isoeugenol.

The barbell back squat is a full body compound movement however a large amount of work is done by the legs.

The powerful benefits of compounding are illustrated by the fact the amount of interest each year becomes larger and larger even though the interest rate remains stable at 4 %.

While 2.37 percent per year may not sound like a large amount of money, over several decades this increasingly compounding fee burden can reduce a consumer's retirement nest egg by half if not more.

«The large amount of energy required to isolate hydrogen from natural compounds (water, natural gas, biomass), package the light gas by compression or liquefaction, transfer the energy carrier to the user, plus the energy lost when it is converted to useful electricity with fuel cells, leaves around 25 % for practical use.»

The PPF plan provides an interest on the amount deposited by the individual, which is compounded over its 15 years tenure to build up a large retirement corpus base for the individual.