Sentences with phrase «compounding effect of the time»

In addition, money taken out early loses the compounding effect of the time value of money.»

Not exact matches

But ultimately this cost will be paid by future generations, who will have to cope with the harmful effects of a changing climate that we compound every time we eat meat ---- unless we act today.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

However, that approximation is less accurate over large movements or over extended periods of time, where growth in fundamentals and compounding effects become important.

Wahl published a paper in Nature Communications in 2015 on the effects of compound flooding, which is when increased river discharge, precipitation and storm surges happen at the same time.

These risks and uncertainties include, among others, those relating to our ability to obtain financing and to form collaborative relationships, uncertainty regarding potential future deterioration in the market for auction rate securities which could result in additional permanent impairment charges, our ability to develop and market diagnostic products, the level of third party reimbursement for our products, risks related to preclinical and clinical development of pharmaceutical products, including the identification of compounds and the completion of clinical trials, the effect of government regulation and the regulatory approval processes, market acceptance, our ability to obtain and protect intellectual property rights for our products, dependence on collaborative relationships, the effect of competitive products, industry trends and other risks identified in deCODE's filings with the Securities and Exchange Commission, including, without limitation, the risk factors identified in our most recent Annual Report on Form 10 - K and any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10 - Q or Current Reports on Form 8 - K.

These risks and uncertainties include, among others, those relating to our ability to obtain sufficient financing to continue as a going concern, our ability to develop and market diagnostic products, the level of third party reimbursement for our products, risks related to preclinical and clinical development of pharmaceutical products, including the identification of compounds and the completion of clinical trials, our ability to form collaborative relationships, the effect of government regulation and the regulatory approval processes, market acceptance, our ability to obtain and protect intellectual property rights for our products, dependence on collaborative relationships, the effect of competitive products, industry trends and other risks identified in deCODE's filings with the Securities and Exchange Commission, including, without limitation, the risk factors identified in our most recent Annual Report on Form 10 - K and any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10 - Q or Current Reports on Form 8 - K.

Through «heart - on - a-chip» technology — modeling a human heart on an engineered chip and measuring the effects of compound exposure on functions of heart tissue using microelectrodes — Lawrence Livermore National Laboratory (LLNL) researchers hope to decrease the time needed for new drug trials and ensure potentially lifesaving drugs are safe and effective while reducing the need for human and animal testing.

The authors wrote: «We argue that in the era of precision medicine, potential differences in response to compounds that disrupt the cholesterol biosynthesis pathway must be respected, especially as their effect may be defined by both genetic makeup and life events at the same time.»

These risks and uncertainties include, among others, those relating to our ability to obtain sufficient financing to continue as a going concern, the outcome of the review of the continued listing of our common stock on The Nasdaq Stock Market, our ability to develop and market diagnostic products, the level of third party reimbursement for our products, risks related to preclinical and clinical development of pharmaceutical products, including the identification of compounds and the completion of clinical trials, our ability to form collaborative relationships, the effect of government regulation and the regulatory approval processes, market acceptance, our ability to obtain and protect intellectual property rights for our products, dependence on collaborative relationships, the effect of competitive products, industry trends and other risks identified in deCODE's filings with the Securities and Exchange Commission, including, without limitation, the risk factors identified in our most recent Annual Report on Form 10 - K and any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10 - Q or Current Reports on Form 8 - K.

We show for the first time that kahweol is an anti-angiogenic compound with inhibitory effects in two in vivo and one ex vivo angiogenesis models, with effects on specific steps of the angiogenic process: endothelial cell proliferation, migration, invasion and tube formation on Matrigel.

Since we don't have much time to work with, we're going to overlap our exercises to achieve the max with each rep.. The idea is this: the cumulative effects of synergistic and compound movements get real results with the abs, glutes, arms and shoulders.

The compounds of this fabulous product were tested multiple times to ensure the best results possible — with minimal chance of side effects and unpredictable outcomes.

The specific effects of food structure (increased satiety, reduced transit time and glycaemic response), fibre (improved faecal bulking and satiety, viscosity and SCFA production, and / or reduced glycaemic response) and Mg (better glycaemic homeostasis through increased insulin secretion), together with the antioxidant and anti-carcinogenic properties of numerous bioactive compounds, especially those in the bran and germ (minerals, trace elements, vitamins, carotenoids, polyphenols and alkylresorcinols), are today well - recognised mechanisms in this protection.

Our common agricultural nightshades are much safer, but still contain small levels of certain problematic compounds that have actually been linked to Arthritis and other inappropriate calcification type effects in certain people that are sensitive to them and over long periods of time of consuming them.

The CrazyBulk company has invested a lot of money and time to create formulations that have no compounds to give side effects, while taking advantage of all the positive effects of other steroids.

Fortunately, through an autoimmune diet, exercise, spending time in nature, good hydration, and using anti-inflammatory compounds such as glutathione precursors (the body's master antioxidant), we can mitigate the effects of toxins on the body and help better manage Hashimoto's hypothyroidism.

It is all a compound effect of bad decisions taken almost every day over a considerable period of time.

This graph is intended to illustrate the compounding effects of higher fees over a long period of time.

When the compounding effect of interest earned is combined with time, the growth of your money becomes exponential, as in the case of the penny.

This compounding effect adds a temendous amount of money to the RRSP over time.

Reinvesting distributions may enhance investment returns over time due to the compounding effect of growth and / or distributions over time.

Even if you've been paying on time each month, you're still fighting the effects of compounding interest.

«Due to the effects of compounding, their performance over longer periods of time can differ significantly from their stated daily objective.

Higher return is very important since time works for you and even several extra percent annually will make a big difference in the long run because of compound interest effect.

The Compound Annual Growth Rate, usually expressed as a percentage, represents the cumulative effect of a series of gains or losses on an original amount over a period of time.

However, that approximation is less accurate over large movements or over extended periods of time, where growth in fundamentals and compounding effects become important.

It is important for investors to understand the effects of compound interest as they have a big impact on fees and performance over longer time periods.

Not only will that reduce part of your debt but you will also be saving interest that you would have been paying on that debt and the compound effect is more significant as time goes by.

The compounding effect can be dramatic over an extended period of time and can make a big difference in the accumulation of a retirement nest egg.

A material part of earnings is reinvested in the business so that over time there is a compounding effect, much the same as happens in a saving account if you reinvest the interest.

Consider that the provider may modify the methods it uses to evaluate investment opportunities from time to time, that model results may not impute or show the compounded adverse effect of transaction costs or management fees or reflect actual investment results, and that investment models are necessarily constructed with the benefit of hindsight.

Workers contribute only a little to stocks, and do not enjoy a strong effect of compounding, since the proceeds of the early investments are taken out of the stock market as time goes on.

For example, a loan that has an interest rate of 13 percent that is compounded quarterly, or four times a year, would have the function «= Effect -LRB-.13, 4).»

This is a straight calculation of balance times the rate, and does not take into account the effects of compounding interest.

Method 2 only realises inflation at the end of the holding period, but still accounts for the compounding effect against the dollar over time.

Even if inflation did not exist, the effects of compound interest make it well worth one's time and effort to invest in the stock market.

«It should be borne in mind that internal ocean oscillations substantially modulate the solar induced effects by inducing a similar atmospheric response but from the bottom up (and primarily from the equator) sometimes offsetting and sometimes compounding the top down (and primarily from the poles) solar effects but over multi-decadal periods of time the solar influence becomes clear enough in the historical records.

In this vein, I think of compound interest and its multiplicative effect on money held for a long time.

In fact, some types of trees actively consume certain types of air pollution.Looking at oxygenated volatile organic compounds (oVOCs)-- which are emitted from both manmade and non-manmade sources and can have serious effects on the health of the environment and humans — the team found that deciduous plants take up oVOCs as much as four times more rapidly than previously thought.

Even if you've been paying on time each month, you're still fighting the effects of compounding interest.

I believe using the whole life to leverage investments in real estate can help you minimize the effect of interest paid to banks and by doing it right and structuring the policy to maximize the cash value it can compound pretty well over time.

There is a plant native to Australia known as «Gympie Gympie» that is like a supercharged version of poison ivy; the compounds secreted by the leaves of the plant are so incredibly painful that people describe the effects, which linger for weeks after exposure, as like a combination of being doused in hot acid and electrocuted at the same time.

If you're not listening closely the powerful bass is enough to divert your attention from these sorts of effects, but it also actually compounds the problem, upsetting arrangements and at times even making lead vocals sound almost like incidental parts of a mix when left to compete with a strong bass line.

That research found that racism has a compounding effect on mental health, with 97 per cent of Aboriginal and Torres Strait Islander people surveyed experiencing incidents of racism multiple times.

Being disliked by peers may compound adjustment problems, leading to cascading negative effects of peer problems over time.

Success Habits Keep a quarterly finance sheet to keep track of Net Worth, Assets, Liabilities, Income, & Expenses List out yearly goals for family, finance, health, learning and track each week Make sure to do things daily to get closer to goals Dave Ramsey Lifestyles Unlimited REIs for networking Checklists Books Millionaire Real Estate Investor — Gary Keller Rich Dad Poor Dad — Robert Kiyosaki The Complete Guide to Buying and Selling Apartments — Steve Berges 48 Days to the Work You Love — Dan Miller What Color is Your Parachute — Richard Bolles The Slightest Edge — Jeff Olson Compound Effect — Darren Hardy Quotes «Leverage is key to wealth» — In regards to money, time, knowledge «Money is on the other side of fear» «Most people overestimate what can be done in the short term and underestimate what can be done in the long term» «If you give a house a cookie...» «What gets measured gets done» «Spectacular achievement is always preceded by spectacular preparation» «Those who say it can't be done should get out of the way of those doing it» «Go as far as you can see, once you get there, you will see farther» «Play the game of money to win, don't play not to lose» «Don't quit when you are tired, quit when you are done» «Make sure your ladder to success is on the correct wall»