They measured cellular toxicity of 156
compounds on these cell lines, which represented individuals from nine subpopulations throughout Europe, Africa, Asia and the Americas.
Not exact matches
To put the combinatorial screen with the CLOUD to the test, Kubicek's group investigated the effect of pairwise combinations of CLOUD
compounds on the viability
on KBM7 leukemia
cells, a
cell line well suited for drug experiments.
Their method, called PRISM, uses a molecular barcoding system to test potential drug
compounds on cancer and other
cell lines at an unprecedented scale and speed.
Historically, a potential therapeutic
compound would be tested
on cancer
cell lines to validate the functional efficacy of the
compound.
Most other nutrients,
on the other hand, are more actively transported - there are certain receptors
lining those intestinal
cells (
cells called enterocytes, if anybody cares) that pull salts, sugars, amino acids, etc. through the intestinal
lining into the
cells in exchange for other
compounds (e.g. they'll pull in a hydrogen ion at the same time as an amino acid, then exchange the new hydrogen atom for a sodium molecule later.)
The Canadian study that isolated avocado's
compound avocotin B to observe its effect
on AML
cells» conversion to apoptosis mode started with this
line: «Treatment regimens for acute myeloid leukemia (AML) continue to offer weak clinical outcomes.»