Sentences with phrase «concentration of adenosine»

However these compounds were designed as competitive antagonists to be active in the brain of patients having low concentration of adenosine whereas high levels adenosine are produced by ectonucleotidases, especially CD73 and CD39 that are overexpressed in the tumor microenvironment.

They found that the concentration of adenosine rises steadily during periods of alertness, when the brain uses the most energy, and drops during naps or deep sleep.

iTeos Therapeutics has developed a novel and potent best - in - class A2A blocker that has been specifically optimized for immuno - oncology indications to retain a high potency in the adenosine - rich environment found in tumors and to restore cytokine production even in the presence of high concentrations of adenosine.

Not exact matches

Adenosine 3», 5» - monophosphate at a concentration of 5 x 10 - 7 mole per liter causes a 400 percent increase in the rate of phosphorylation of histone catalyzed by a partially purified enzyme preparation from rabbit brain.

The researchers reported a 24-fold increase in adenosine concentration in the blood of the animals after acupuncture, which corresponded to a two - thirds reduction in discomfort, as revealed by how quickly they recoiled from heat and touch.

The difference in the concentration of protons across these two environments enabled protons to flow into the cell, driving the production of a molecule called adenosine triphosphate (ATP) which powered the growth of cells, just as it does today.

The company showed how they first defined A2A as the receptor required for mediating the effect of adenosine on immune cells within the tumor microenvironment and reported the characterization of a novel immuno - oncology - dedicated adenosine receptor 2A antagonist that functions in the high adenosine concentration found in tumors.

EOS100850 promotes anti-tumor efficacy in mouse tumor models in combination with several immune - checkpoint inhibitors, retains high potency in the presence of elevated intra-tumoral adenosine concentrations, and is non-brain penetrant.

«These preclinical results show the potential of our compound to target the inhibition of the A2A receptor in the challenging context of tumor - like adenosine concentrations.

EOS100850 potently inhibits A2A receptor in T lymphocytes, at single digit nanomolar concentrations, independently of adenosine concentrations

This study investigated the influence of chronically administered curcumin on normal ageing - related parameters: lipid peroxidation, lipofuscin concentration and intraneuronal lipofuscin accumulation, activities of the enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx), and Na (+), K (+), - adenosine triphosphatase (Na (+), K (+), - ATPase) in different brain regions (cerebral cortex, hippocampus, cerebellum and medulla) of 6 - and 24 - month - old rats.