Sentences with phrase «conditional knockout»
The phrase "conditional knockout" refers to a scientific technique used in genetics research. It involves turning off or "knocking out" a specific gene in an organism under certain conditions, like at a specific stage of development or in a particular body tissue. This approach helps scientists study the function of that gene and understand its effects on the organism. Full definition
We use what are called conditional knockout mice, in which a gene is deleted only in a specific organ or group of cells.
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Conditional knockout of Uhrf1, in a region of the forebrain, led to the activation of endogenous retroviral elements (ERV) in the genome, which are otherwise silenced by methylation.
«Eliminating endothelial CD146 by conditional knockout in two different mouse models of colitis significantly reduced the severity of inflammation and decreased tumor incidence and tumor progression in a mouse model of CAC,» reports lead investigator Xiyun Yan, PhD, from the Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing.
The team is now working on other conditional knockout and gene expression studies of Esrp1 and Esrp2's roles in the face, lungs, gut, kidney, and other organs.
To this aim we generated new conditional knockout mouse strains, which are currently analyzed to unravel the mechanism of a recently discovered unexpected protective role of TNFSF14 / LIGHT by our lab in an Inflammatory Bowel Disease (IBD)- like mouse model.
genOway guarantees freedom to operate (FTO) and offers important time gain in conditional knockout development time for industry scientists.
Short Research Communication Generation of Smurf2 Conditional Knockout Mice Yi Tang, Liu - Ya Tang, Xuan Xu, Cuiling Li, Chuxia Deng, Ying E. Zhang Int.
Her doctoral work with Dr. Virginia Smith Shapiro focused on elucidating the role of transcription regulators (NKAP, HDAC3 and Runx1) in T cell maturation using conditional knockout mouse models and multi-color flow cytometry, and identifying novel mechanisms such as complement and sialylation that monitor the maturity of recent thymic emigrants.
Her current project involves examining neurodevelopmental changes in mGluR5 conditional knockout mice.
Because mice lacking both genes would not be born alive, the scientists followed up this lead by making «conditional knockout mice,» in which Esrp1 and Esrp2 activity was normal early in fetal development, but then was switched off in skin epithelial cells.
Technicians there can generate a dazzling array of conditional knockouts.
Design and generate gene targeting constructs, including knockin report genes, knockin mutations, conventional / conditional knockouts, and BAC transgenics and constructs for CRISPR / cas9 targeting