Sentences with phrase «conditions on any of the measures»

There was no difference between the two active treatment conditions on any of the measures.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

That's why we hold over 200 individual investment positions in Strategic Growth, why we diversify across industries, why I left complete put option coverage underneath the Fund's portfolio even in response to a favorable shift in our measures of market action two weeks ago (now neutral), why the dollar value of our shorts never materially exceeds our long holdings, and why even in the most favorable conditions, the Fund can establish leverage only by investing a small percentage of assets in call options (never on margin).

Presently, wicked valuations are coupled with still - unfavorable market internals on our measures, and have now been joined by the most extreme «overvalued, overbought, overbullish» syndrome of conditions we identify.

With the S&P 500 within about 8 % of its highest level in history, with historically reliable valuation measures at obscene levels, implying near - zero 10 - 12 year S&P 500 nominal total returns; with an extended period of extreme overvalued, overbought, overbullish conditions replaced by deterioration in market internals that signal a clear shift toward risk - aversion among investors; with credit spreads on low - grade debt blowing out to multi-year highs; and with leading economic measures deteriorating rapidly, we continue to classify market conditions within the most hostile return / risk profile we identify — a classification that has been observed in only about 9 % of history.

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As I've regularly noted in recent months, our immediate outlook is essentially flat neutral for practical purposes, though we're partial to a layer of tail - risk hedges, such as out - of - the - money index put options, given that a market decline on the order of even 5 % would almost certainly be sufficient to send our measures of market internals into a negative condition.

This assessment will take into account a wide range of information, including measures of labor market conditions, indicators of inflation pressures and inflation expectations, and readings on financial and international developments.

The chart below shows historical instances where overvalued, overbought, overbullish conditions matched current extremes, and where bubble - tolerant overlays (based on measures of market internals and credit spreads) were also unfavorable, and where the S&P 500 had established an all - time high.

Some would argue that by acting cautiously on balance sheet normalization (without actively countering impacts of ECB policy measures), Fed policymakers have partially ceded control of financial conditions to foreign monetary authorities, but the same can be said about other central banks as well, for long - term rates are correlated among advanced economies:

Our proposals also include a number of other measures to improve workplace conditions: enhancing members» right to refuse dangerous work; specific measures to reduce stress for front - line workers and shift workers; improved collective agreement language on workplace harassment and discrimination; strong maternal health provisions; and fairness for injured workers.

As for what this means for the timing of a Federal Reserve (Fed) rate hike, data about the U.S. economy on balance exceed the reasonable measures a «data dependent» Fed might require to move off of «emergency interest rate» levels, as BlackRock's proprietary «Yellen Index» of labor market / economic conditions shows in the chart below.

With the overvalued, overbought conditions of October now compounded by rising yield pressures and overbullish sentiment on a variety of measures (investment advisors are again down to just 21.3 % bears), we remain defensively positioned here.

Another indicator of financial conditions is the slope of the yield curve, as measured by the spread between the yield on 10 - year bonds and the target cash rate.

While the combination of rapid credit growth and below - average interest rates suggests that financial conditions remain expansionary, the slope of the yield curve, as measured by the spread between the yield on 10 - year bonds and the cash rate, suggests a somewhat different picture.

The selective willingness to act on trend - following measures even when our market return / risk estimates are negative (but only in the absence of hostile syndromes of market conditions) is one of the two adaptations we've introduced to our investment approach in the recent market cycle.

Bergson's solution reveals to him a series of necessary conditions, the arrangement of which can be discerned by examining his textual use of terms such as «allows,» «symbolizes,» «measures, and «must» on the one hand as well as «requires» and «necessitates» on the other.1 These two basic sets of terms have a general difference in that what precedes the first set usually constitutes a necessary condition, whereas what precedes the second will in large measure serve as a sufficient condition.

It is defined in Article 2 of the Convention on the Prevention and Punishment of the Crime of Genocide (CPPCG) as «any of the following acts committed with intent to destroy, in whole or in part, a national, ethnical, racial or religious group, as such: killing members of the group; causing serious bodily or mental harm to members of the group; deliberately inflicting on the groups conditions of life, calculated to bring about its physical destruction in whole or in part; imposing measures intended to prevent births within the group; [and] forcibly transferring children of the group to another group.»

The glycemic index (GI) also is extensively used as a tool to help diabetics manage their condition by providing a measure of the effect of foods on blood glucose levels after eating.

Computerized monitoring of wind, temperature and solar radiation information measures evaporation to inform the superintendent on water needs to maintain the fairways and greens in top playing condition.

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If you're new to compression stockings or need assistance finding the right size, our compression stockings buying guide can help you learn how to measure for compression stockings as well as which level of compression could be best for you depending on the condition.

Additionally, a careful observation of the symptoms of mastitis on your breasts and overall health condition will help you to take medications and other measures that can assuage the condition.

Five conditions are measured on a 0 - 2 scale to check the responsiveness of your baby.

«The Buhari presidency is keen to ensure that Nigerians are lifted and that if necessary on an ongoing basis palliatives measures would always been considered to address the conditions of the people.»

These measures were adopted as a necessary condition of imposing necessary disciplines on the fiscal regimes of member states in order to convince the markets that the euro would be a viable currency.

Tory backbenchers are risking resuscitating the party's «nasty» tag today, as they put the finishing touches on a package of policy measures which includes harsh conditions on housing benefit for teenage mothers.

The programme also included a number of previously announced measures, such as giving agency workers equal rights on pay, holidays and basic conditions, and introducing a binding commitment to abolish child poverty by 2020.

The Metropolitan Archbishop of Accra, Charles Palmer - Buckle, has attributed the insanitary conditions in the city to the sense of indiscipline, calling on city authorities to enforce sanitation laws and put in place proactive measures to address the menace.

Charging Time: This is a really hard thing to measure because it depends on so many factors: temperature, the condition of the battery, how many other batteries are charging.

Jay Vroom, CEO and spokesman at CropLife America, a trade partnership of seed and pesticide manufacturers, says studies measuring the effect of neonics on bees in field conditions «consistently demonstrate no negative effects.»

The report calls for a battery of government and institutional measures to better support scientists on short - term contracts, including gathering comprehensive data on their working conditions, helping them devise career plans, creating more academic jobs, and encouraging them to apply for permanent positions.

Specifically, the paper found that the same water that has been measured in the fjord is under the glacier, lending credence to the idea that the continuity of the glacier depends on the conditions outside the glacier in the fjord.

Fourteen months on, it's hard to measure how much conditions have changed on the nation's hundreds of campuses — but, happily, there are some hopeful signs.

Lead author Dr. Joseph Ripberger said: «We matched high - resolution data on climate conditions from the Oklahoma Mesonet to the Meso - Scale Integrated Socio - geographic Network (M - SISNet), an address - based panel survey that continuously measures public perceptions of climatic conditions over time.»

While some research was previously done by his and other groups on a smaller scale, «This is the first real description of a method that could be used broadly across a range of conditions to operationally measure diagnostic errors and associated bad outcomes so that we can track our performance and see whether our interventions are making a difference,» Newman - Toker says.

While late - term gestation was associated with an increase in the rate of abnormal conditions at birth and with worse physical outcomes during childhood, it was also associated with better performance on all three measures of school - based cognitive functioning measures during childhood,» the study concludes.

(The condition's severity was assessed using a scale that measured feelings of being frozen, mute, numb and so on.)

The results provide the most comprehensive and up to date picture of the effect of the economic downturn on Greece, which received its first bailout of $ 110 billion in 2010 with strict conditions including tough austerity measures; privatisation of government assets; and dramatic changes to the country's industries and government.

The UAH team estimated lightning nitric oxide (NO) emissions based on NLDN observations, measured the resulting ozone created by the lightning downwind of the storms, where clear conditions allowed Lidar to function and quantified the ozone enhancements due to lightning.

The research, commissioned by the Department of Health, is the first to present estimates for the number of babies with brain injuries based on a definition that includes multiple conditions in one measure.

This is likely due to increased vigilance on the part of beekeepers, a greater availability of mite control products and environmental conditions that favored the use of timely and effective mite control measures.

For now, the tool — a website app with a simple interface — pairs schistosomiasis, a neglected tropical disease, with malaria and allows users to enter factors based on local conditions and political constraints to determine the outcome of integrating control measures.

Today, persistently toxic economic conditions, uncertainty, joblessness, and the possibility of further austerity measures continue to put a great strain on the Greek public, the authors say.

These data were obtained on November 17, 2013 during the first week of operation of GPI and in relatively challenging weather conditions, but with GPI's advanced adaptive optics system and coronagraph the planets can still be clearly seen and their spectra measured (see Figure 2).

(E) establishes performance measures for assessing the effectiveness of adaptation strategies intended to improve resilience and the ability of natural resources in the coastal zone to adapt to and withstand the impacts of climate change and ocean acidification and of adaptation strategies intended to minimize those impacts on the coastal zone and to update those strategies to respond to new information or changing conditions; and

The team compared the scattering coefficient obtained by their approach with the scattering coefficient measured on board the aircraft and found good agreement between the estimated and measured scattering coefficients for a wide range of observational conditions.

The current project will use high - resolution mass spectrometry - based metabolomics approaches to measure temporal and spatial changes of metabolic pathways in the RPE and retina under both physiological and disease conditions, with a focus on mTOR - mediated signal transduction pathways.

The effect of insulin on phosphorylation of Akt protein was measured by Western blot in enhanced hiPS - HEP cells from C18 on Day 12 post-thawing (n = 3 for the [+] condition; n = 1 for the -LSB----RSB- control).

Combining several neuroimaging techniques and psychophysiological measures, we aim to assess the impact of individual GABA concentrations in the amygdala on neural and behavioral fear correlates using a classical fear conditioning and extinction paradigm.