In the 1980s and 1990s, for example, Frederick Hayden of the University of Virginia School of Medicine in Charlottesville
conducted challenge studies with influenza that helped speed the development of Tamiflu and Relenza, drugs that have become the mainstays of treatment.
A group at the University of Oxford led by pediatrician Andrew Pollard has
conducted a challenge study of experimental vaccines against typhoid and paratyphoid.
Not exact matches
Economists have analyzed extensively how platform markets may pose unique
challenges for antitrust analysis.377 Specifically, they stress that analysis applicable to firms in single - sided markets may break down when applied to two - sided markets, given the distinct pricing structures and network externalities.378 These
studies often focus on the
challenge that two - sided platforms face in attracting both sides — the classic coordination problem of having to attract buyers without an established line of sellers, and vice versa.379 Economists tend to conclude that — given the particular
challenges of two - sided markets380 — antitrust should be forgiving of
conduct that might otherwise be characterized as anticompetitive.381
A new Merrill Lynch
study conducted in partnership with Age Wave, «Women and Financial Wellness: Beyond the Bottom Line,» celebrates the progress made by women while examining the financial
challenges women still face throughout their lives, and offers potential solutions.
«The next steps in DPX - RSV will be expensive steps (large RSV infection avoidance
studies, or perhaps even
challenge studies, will need to be
conducted in Phase 3), and so we agree with management's strategy to identify cash - contributing partners before investing its own capital in new DPX - RSV clinical initiatives,» he added.
A double - blind, placebo - controlled food
challenge was
conducted for other participants (with a total of 9.4 g of peanut protein administered in increments) in accordance with standard dose - escalation procedures25 (see the
study protocol).
The research team, led by Glyn Howatson and Phillip G. Bell at Northumbria University in the U.K.,
conducted this double - blind, placebo - controlled
study to identify the effects of Montmorency tart cherry juice on recovery from a metabolically
challenging exercise: prolonged, high - intensity cycling.
To provide information on
challenges that school districts have faced, this testimony draws on work GAO
conducted as part of its ongoing
study of implementation of the changes.
This is the first
study on this topic to be
conducted in BC and the findings support to - date anecdotal accounts of midwives» commitment to promoting and supporting normal birth, some of the
challenges they face, and identify a number of topics for further exploration.
The way he has gone about it and the
conduct of his own political party, the All Progressives Congress should be a useful global
study in how not to tackle the
challenge of campaign finance.
Given such variation, as well as the expense and logistical
challenges of
conducting population surveys, indigenous communities will be important partners in developing workable conservation strategies, such as the creation of new protected areas or harvest quotas, the
study suggests.
And scientists who
conduct human
challenge studies, which typically involve a few dozen participants, say they have critical benefits: In addition to saving time and money, they can reveal harm caused by a potential drug or vaccine before it enters large - scale human efficacy trials.
The evaluation of THN programs is
challenging: randomized controlled trials are often considered the gold standard of scientific
study, but
conducting trials for THN would often be unethical and fraught with difficulties given the infrequency and unpredictability of overdose.
The flu
challenge study, which began in September 2013, was
conducted at the NIH Clinical Center in Bethesda, Maryland, in the specially designed Clinical
Studies Unit, which has distinct isolation and infection control features.
In a
study published in the Journal of the American Chemical Society, ORNL researchers
challenged a long - held assumption that a battery's three main components — the positive cathode, negative anode and ion -
conducting electrolyte — can play only one role in the device.
It is important to note that human
challenge studies are
conducted according to strict criteria designed to provide meticulous attention to volunteer safety and
challenge studies would never be used for certain deadly pathogens, such as Ebola.
Researchers from the University of Missouri have
conducted the first
study analyzing the perspectives of adolescents with autism to identify
challenges as they «age out» of services.
To
conduct the new
study, Panoz - Brown and Crystal developed a series of
challenges in which rats were asked to recall up to 30 different scents — basil, strawberry and banana, among many others — to earn a treat.
«
Conducting this
study was very
challenging,» says Dr Inge Kroidl, clinical research coordinator of «RV 217,» as the
study in Tanzania is called.
«Our prosocial and altruistic impulses play a very important role in sustaining complex societal structure,» explained Giorgia Silani, the principal investigator of this research
conducted at SISSA and now a researcher housed in University of Vienna, «However,
studying altruism and its neural basis in lab - based environment poses unique ethical
challenges.
Since the mid-1990s, FDA has deemed that organisms used in
challenge studies are experimental medicines, and the agency has required researchers to submit Investigational New Drug applications before
conducting trials.
«Singling out specific research
studies, and implicitly questioning the integrity of the researchers
conducting those
studies, can be viewed as a form of intimidation that could deter scientists from freely carrying out research on important national
challenges,» the letter states.
Conducting the
study was not without its
challenges.
To transcend the technical
challenges, Roth and UNC colleagues, including postdoctoral fellows Sheng Wang, PhD, and Daniel Wacker, PhD,
conducted a series of painstaking
studies over several years — outlined in the Nature paper — to coax DRD2 to crystalize while bound tightly to risperidone.
Through crowdsourcing — an open call for voluntary assistance from a large group of individuals — Americans can
study and tackle complex
challenges by
conducting research at large geographic scales and over long periods of time in ways that professional scientists working alone can not easily duplicate.
A multi-partner
study published today in Nature Communications has addressed phonon lifetime measurement
challenges using inelastic neutron scattering (INS) and neutron resonant spin - echo (NRSE) experiments
conducted at the Institut Laue Langevin (ILL) in Grenoble, and Laboratoire Léon Brillouin (LLB) Saclay, France.
We applaud the staff of our research sites for their devotion to the
challenges of
conducting these
studies, and the care they provide to our volunteers.
The
study,
conducted by German researchers Eva - Marie Meemken and Matin Qaim from the University of Goettingen and published in the journal Annual Review of Resource Economics,
challenges many beliefs that have helped the organic food industry grow into an $ 82 billion global market.
The
study was
conducted as a
challenge test against Escgerichia coli (E.coli) bacteria.
The research team, led by Glyn Howatson and Phillip G. Bell at Northumbria University in the U.K.,
conducted this double - blind, placebo - controlled
study to identify the effects of Montmorency tart cherry juice on recovery from a metabolically
challenging exercise: prolonged, high - intensity cycling.
This feeling of vulnerability contributes to one of the other
challenges for doing lesson
study:
conducting a rich and meaningful debriefing.
We have
conducted a couple of book
studies with her book, and the teachers involved unanimously declare it a
challenging and informative — if not attitude - changing — work.
Promising Results, Continuing
Challenges: National Assessment of Title I (1999) summarizes findings from a variety of
studies conducted for the National Assessment of Title I, examining the implementation and impact of the program.
Although leadership - related impact
studies are
challenging to
conduct, the analyses hold great potential for informing effective principal talent management design and leadership workforce retention.
The
study looks at how the money is spent, the degree to which program coordination occurs, research
conducted by or promoted by the Department of Education, collaboration within states and how the DoE deals with these
challenges.
We positioned interactive, dynamic experiences early in each face - to - face PD session and
conducted them throughout the
study to
challenge participants» (very likely) traditional assumptions.
A national
study conducted by the Fordham Institute found that 58 % of teachers have received no professional development focused on teaching academically advanced students in the past few years and 73 % of teachers agreed that «Too often, the brightest students are bored and under -
challenged in school — we're not giving them a sufficient chance to thrive.
In an effort to document and promote school models and practices that effectively serve students with disabilities in charter schools, the Center on Reinventing Public Education (CRPE) asked the National Center for Special Education in Charter Schools (NCSECS) to
conduct two case
studies about exemplary schools that respectively leverage available opportunities and mitigate
challenges.
The Broad Foundation Donates $ 25 Million To UCSF Stem Cell Program Because scientists were prohibited by President George W. Bush's stem cell policy from
conducting these
studies in federally funded buildings, UCSF scientists were forced to carry out their research in
challenging circumstances — first in segregated space within an existing UCSF lab, later in rented space at an off - campus site and subsequently 40 miles away at Geron Corp., through a joint project.
To do so, CAREI
conducts comprehensive
studies that provide information about
challenges confronting schools and practices leading to educational improvement.
conducts studies that provide empirical information about
challenges confronting schools and practices that lead to educational improvement.
SPR
conducts these
studies using rigorous quantitative and qualitative methods to surface effective practices, lessons learned, and
challenges.
The Origins of the Domestic Dog are
Challenged: It has always been suggested that the domestic dog originated in East Asia until findings from recent scientific
studies that have been
conducted on dogs in Africa.
The
studies were only
conducted in purebred dogs, making interpretation to other breeds and mixed breeds
challenging.
Efficacy was confirmed in a one - year duration of immunity
study in which none of the vaccinated animals were infected with rabies when
challenged 12 months after a single dose of DEFENSOR.4 During a field safety
study conducted in 200 ferrets, no significant post-vaccination reactions were observed.5
Based on a
study conducted on their behalf by CE Delft showing the environmental impact of mink farming compared with the production of other clothing, GAIA
challenged whether the claim about the eco-friendliness of fur was misleading and could be substantiated.
In a wide - ranging December 2013
study,
conducted to support Our Children's Trust, a group advancing legal
challenges to lax greenhouse gas emissions policies on behalf of minors, Hansen called for a «human tipping point» — essentially, a social revolution — as one of the most effective ways of combating climate change, though he still favors a bilateral carbon tax agreed upon by the United States and China as the best near - term climate policy.
Singling out specific research
studies, and implicitly questioning the integrity of the researchers
conducting those
studies, can be viewed as a form of intimidation that could deter scientists from freely carrying out research on important national
challenges.
Dawn: The University of Agriculture Peshawar has recently established the Climate Change Centre to
conduct studies and research on climate change and cope with the
challenges posed by changing weather patterns.
The
study,
conducted by the American Bar Association and the Hazelden Betty Ford Foundation, surveyed lawyers about alcohol and drug use and mental health
challenges.