Sentences with phrase «conducted in cancer cells»

Not exact matches

A series of preliminary Mayo Clinic studies conducted in 2010 showed promise for the potential use of a chemical component of green tea (epigallocatechin gallate) in reducing the number of cancer cells in patients with chronic lymphocytic leukemia.

Now classified as an assistant scientist and paid by Keely's grants, Ponik continues to conduct her own research identifying cell - signaling changes in cancer metastasis.

The research, conducted in cell lines and mouse models, explored enhancing the cancer - killing effects of PARP inhibitors not only in regard to AML but also triple - negative breast cancer.

«Despite the low infection levels of mouse cells with oHSV, we were able to cause a delay in tumor growth in one of the cancer models and even cure many of the mice in a second model,» said first author Jennifer Leddon, who conducted much of the laboratory work during a research experience in the Center for Childhood Cancer and Blood Discancer models and even cure many of the mice in a second model,» said first author Jennifer Leddon, who conducted much of the laboratory work during a research experience in the Center for Childhood Cancer and Blood DisCancer and Blood Diseases.

The studies not only point to the future possibility of specific microRNAs as a treatment for colorectal cancer, but also to the importance of external metabolic events conducted outside the cancer cell in the progression of the disease — factors that could someday be targeted to help slow metastasis, or even block it entirely.

Today, a team of researchers at Cold Spring Harbor Laboratory reports in the journal Genes & Development that they have arrived at «new insights into signaling events that underlie metastasis in ovarian cancer cells,» says Gaofeng Fan, Ph.D., postdoctoral investigator who conducted most of the experiments, in the laboratory of his mentor, CSHL Professor Nicholas K. Tonks.

The Duke team, lead by Timothy Haystead, Ph.D., a professor in the Department of Pharmacology and Cancer Biology, and Emily Derbyshire, Ph.D., assistant professor in the Department of Chemistry, conducted cell - based experiments to learn how the Takinib molecule influences a series of events to suppress cell death.

A phase I clinical trial conducted by investigators at the University of Texas San Antonio, showed that the combination of HCQ and the chemotherapy drug vorinostat in 27 patients with advanced solid tumors, including renal cell carcinoma and colon cancer, was clinically safe and inhibited autophagy.

In a four - year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kilIn a four - year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kilin advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kilin the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kilin the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kill.

«Further tests conducted at the Institute for Molecular Bioscience demonstrated that this compound was more toxic to cancer cell lines than other compounds found in sea slugs.»

The study, conducted in both human and mouse cells, shows that cancer genomes lose copies of repetitive sequences known as ribosomal DNA.

Previous in vitro studies conducted by researchers in other countries showed that this molecule was able to reduce the multiplication and increase the mortality of cells from melanoma, the most aggressive type of skin cancer, as well as breast cancer and neuroblastoma, a tumor that typically affects patients aged 15 or younger.

The cellular disarray is similar to that seen in cancer, he says: Both cancer cells and the brain cells show «no orderly conduct.»

The team's experiments in cell cultures, conducted with funding from an American Brain Tumor Association Discovery Grant, showed that coibamide A cuts off the cancer cells» ability to communicate with blood vessels and other cells, eventually starving the cell and triggering its death.

The study, which is published in the journal Nature Communications, was conducted on human tumour cells and on mice, and offers hope of a much improved therapy for a severe form of cancer.

Given the widespread use of the HeLa cell line, Lars Steinmetz and his colleagues at EMBL decided that conducting an extensive analysis of its genome could illustrate the changes caused by cancer — and also help researchers compare versions of the cell line that have evolved over decades of growth in labs around the world.

Drew Pardoll, Glenn Dranoff, Elizabeth Jaffee, Hyam Levitsky, and colleagues conduct preclinical studies showing that a vaccine composed of tumor cells irradiated and genetically modified to produce immune system growth factor GM - CSF (granulocyte - macrophage colony - stimulating factor)-- which would become known as the therapeutic cancer vaccine GVAX — could induce potent, specific, and long - lasting anti-tumor immunity in multiple mouse tumor models.

With the reference cell census data in hand, the research team is excited to conduct additional studies, including ones involving models or human patients with gastrointestinal conditions — Crohn's disease, ulcerative colitis, gastrointestinal cancers, forms of food allergy, etc. — aimed at identifying changes in gene expression and epithelial structure and function that could reveal new insights and opportunities for therapeutic development.

With key strengths in advanced medical imaging, cell biology, genomics, immunology and stem cell biology, our scientists and their skilled staff conduct research on some of the most debilitating diseases of our time: heart disease and stroke, Alzheimer's, cancer, organ failure, diabetes and many others.

We conducted a meta - analysis in nonmetastatic breast cancer patients treated by neoadjuvant chemotherapy (NCT) to assess the clinical validity of circulating tumor cell (CTC) detection as a prognostic marker.

In collaboration with Nanyang Technological University, experiments were also conducted to co-deliver paclitaxel and small interfering RNA (siRNA) targeting a protein that prevents cell death (Bcl - 2) to MDA - MB - 231 human breast cancer cell line.

In a study conducted at the University of Texas Medical Center in Houston, researchers found that a water extraction of astragalus restored or enhanced the function of T - cells (white blood cells that play specific roles in the immune system) taken from people with canceIn a study conducted at the University of Texas Medical Center in Houston, researchers found that a water extraction of astragalus restored or enhanced the function of T - cells (white blood cells that play specific roles in the immune system) taken from people with cancein Houston, researchers found that a water extraction of astragalus restored or enhanced the function of T - cells (white blood cells that play specific roles in the immune system) taken from people with cancein the immune system) taken from people with cancer.

Researchers in India recently conducted cell studies showing that one benefit of Ashwagandha is that its extract disrupts cancer cells» ability to reproduce in certain types of cancers [1 - 7], and laboratory analysis indicates that Withania somnifera extract possesses some level of anti-tumor activity and may mitigate many of the negative effects of chemotherapy [1 - 7].

From the study: «In contrast to our previous studies conducted among men with prostate cancer and those with abnormal biopsies that showed high grade prostatic intraepithelial neoplasia or foci of atypical cells (5,6), we did not observe differences in PSA change between the study armIn contrast to our previous studies conducted among men with prostate cancer and those with abnormal biopsies that showed high grade prostatic intraepithelial neoplasia or foci of atypical cells (5,6), we did not observe differences in PSA change between the study armin PSA change between the study arms.

In Wisconsin, a group of researchers conducted a study using mice to see if adding pomegranate juice to their diet made a significant impact on lung cancer cells.

Research conducted at the Comenius University in Slovakia found that key antioxidants in artichoke leaf extract helped induce cell death (apoptosis) and slow cancer cell growth.

A similar 2015 comprehensive study on the cancer - healing effects of artemisinin conducted by Worcester Polytechnic Institute in the UK found that, «Artemisinin reacted with iron to form free radicals which cause cell death.

The phenolic compounds and antioxidants found in walnuts recorded a control on human cancer cells, according to the research conducted in 2010 by the University of Portugal.