Sentences with phrase «cone photoreceptor degeneration»

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PRA is caused by the degeneration of the photoreceptor cells, rods and cones, which are needed for dark and day light vision, respectively.

Genetic defects cause photoreceptor degeneration, which are majorly classified into rod - cone dystrophy called retinitis pigmentosa (rods initially degenerate, followed by cone degeneration), cone - rod dystrophy (cone degeneration, followed by rod degeneration), and Leber congenital amaurosis (LCA).

The illness occurs when a DNA mutation within one of the genes affects the normal ocular development or induces photoreceptor — the cones and rods - degeneration.

A subsequent electroretinography study identified an initial reduction of the cone photoreceptor function which led to the condition being re-classified as a cone - rod dystrophy (CRD), rather than a rod - led PRA, and the disease was termed CORD1 for cone - rod degeneration 1 [36].

Most valuable was the tissue sample from a 15 - year old Stage - 3 retina with distinct regions of varying disease severity (Fig. 4B): Small islands of relatively normal appearing retina (Fig. 4B1) were surrounded by large areas of advanced retinal degeneration with loss of both rod and cone photoreceptors (Fig. 4B2).