Sentences with phrase «congenic background»
In an operant test R6 / 2 transgenic mice (240 - CAG repeats, B6 congenic background) were less able to acquire lever pressing than control animals at an age where motor function is only mildly affected (from 9 weeks), with this deficit being both more pronounced and detected earlier (from 5 weeks) where reinforcement was not solely contingent on responding.
http://www.psychogenics.com/ Not exact matches
It should be noted that the phenotype of this C57BL / 6J - congenic line (Stock No. 028867 Gad2 - IRES - Cre knock - in (C57BL / 6J)-RRB- could vary from that originally described for mice on other genetic backgrounds.
To provide additional genetic information for congenic strains, background strain information can be ascertained using MegaMUGA, a low - cost high - density genotyping platform.
In particular, when made congenic on the C57BL / 6 background, retinal dysplasia is not observed.
Laboratory Animal Genetic Services (LAGS) provides MD Anderson investigators with cost - effective, customized genome scans using polymorphic genetic markers to support rapid congenic line development and background strain characterization for mice and rats.
Many of the strains received have been made congenic, including 87 alleles on a C57BL / 6NCrl background, and several on other backgrounds including BALB / cJ and 129S6 / SvEvTac.
This collection, assembled and maintained by Dr. Lynn Lamoreux while at Texas A&M University, contains pigment mutant mouse strains, virtually all as congenic strains on a C57BL / 6 background.
Spontaneous expansion of the CAG repeat stretch in the CAG 140 KI mouse model, which carries a chimeric mouse / human exon 1 containing around 125 CAG repeats and the human polyproline region inserted in the murine huntingtin gene (Menalled et al., 2003, Hickey et al., 2008), has recently led to a new KI line that carries around 190 CAG repeats (CAG 190 KI) in a congenic C57Bl / 6J background.