Gross brain pathology from infants with presumed or laboratory - confirmed ZIKV
infection, primarily from neuroimaging, closely resembles neuropathology associated with
congenital cytomegalovirus (CMV).48 The most notable difference is the distribution of intracranial calcifications (ie, typically subcortical in
congenital ZIKV
infection and periventricular in CMV).48, 49 Such calcifications are likely dystrophic and related to cell death, either by necrosis, apoptosis, or both.50