Subjects were screened and found not to have hematologic abnormalities, liver disease, kidney disease, macroalbuminuria (> 300 mg / 24 h), untreated thyroid disease,
congestive heart failure, angina, life - threatening malignancies, proliferative retinopathy, diabetic neuropathy, peripheral vascular disease, serious psychological disorders, or a body weight > 136 kg (300 lb).