Last year, Gladstone scientists announced a promising new drug candidate that prevents memory deficits and the loss of
synaptic connections between brain cells — key features of Alzheimer's — in mice modeling the disease.
«Synapse discovery could lead to new treatments for Alzheimer's disease: Scientists have discovered
how connections between brain cells are destroyed in the early stages of Alzheimer's disease.»
A team of researchers led by UNSW Australia scientists has discovered
how connections between brain cells are destroyed in the early stages of Alzheimer's disease — work that opens up a new avenue for research on possible treatments for the degenerative brain condition.
A newborn baby has over 2 billion brain cells, but
connections between these brain cells have not yet been developed and will constitute the majority of the 75 percent of the brain left to grow after birth (Sunderland, 2006).
Between ages 1 and 2, the cerebral cortex adds more than 2 million new synapses —
the connections between brain cells — every second, according to Zero to Three, a nonprofit educational group.
Memories are created through physical and chemical changes in synapses,
the connections between brain cells that are continually remodeled in the ongoing storage and retrieval of information.
Last month, researchers led by Beth Stevens of Boston Children's Hospital reported that a process in which microglia prune excess synapses in the brain during early life can turn on inappropriately later on, possibly triggering Alzheimer's or other disorders marked by damage to
connections between brain cells.
But in the case of synapses, which are
the connections between brain cells, too many or too few can both disrupt brain function.
Instead, it's the largest map to date of
the connections between brain cells — in this case, about 200 from a mouse's visual cortex.
LTP leaves its mark by strengthening some connections between synapses —
the connections between brain cells — and not others.
And the images he's creating are part of an ambitious attempt to understand how
the connections between those brain cells give rise to the mind.
A new in vitro model Scientists developed a new research tool for this study that enabled them to monitor the spread of Tau aggregates whilst changing the synaptic
connections between brain cells.
New research in mice reveals that during sleep
the connections between brain cells, which hold information learned throughout the day, undergo massive shrinkage.
Some people's brains can withstand the ravages of the disease by elongating
the connections between brain cells — a process that seems to counter mental decline.
The researchers also found that these copy number variants occurred more frequently in genes involved in the function of synapses,
the connections between brain cells that transmit chemical messages.
This sudden movement causes stretching and tearing of
connections between brain cells and creates chemical changes that alter normal brain function.
Richard Huganir's research focuses on the mechanisms of synaptic plasticity, the constant change in the strength of
the connections between brain cells that underlies learning and memory.
One study concluded that magnesium threonate increases the number of synaptic
connections between brain cells and boosts the density of synapses (30).
It also repairs brain cell damage and makes
the connections between brain cells stronger.
Understanding
the connection between brain cells, behavior and disease is important and scientists have developed a variety of new techniques that will help them map brain activity.