Sentences with word «connectome»

Sex differences in the structural connectome of the human brain.

Second, I will introduce recent advances in methods for mapping human connectomes in living individuals (Takemura et al., PLoS computational Biology 2016).

The results showed a strong association between florbetapir uptake and decreases in strength of the structural connectome in each of the five areas of the brain studied.

The developing human connectome project: A minimal processing pipeline for neonatal cortical surface reconstruction.

The researchers correlated changes in the structural connectome with results from florbetapir positron emission tomography (PET) imaging, a technique that measures the amount of beta amyloid plaque in the brain.

Theta's advanced and flexible software platform supports the ALCF Data Science Program (ADSP), a new initiative targeted at big data problems, like Gursoy and Kasthuri's brain connectome project.

The mouse connectome lies somewhere in between.

For Sporns, the true value of the human connectome lies in the aggregate behavior of its parts.

«We have begun doing X-ray tomography on large brain tissues, then we've gone deeper into specific tiny regions of interest in the same tissue with an electron microscope to see the full connectome there,» Dyer said.

If you grew up in a world where a megabyte is a big dataset, you probably have no hope of understanding the scale of a human connectome dataset.

Both avenues of connectome study promise all sorts of insights about how the brain works.

To date, we only have a complete connectome down to the level of individual neurons for the simple nematode worm.

Adding to the challenge, Seung says, is the fact that an individual's connectome changes over time as neurons grow new branches and prune old ones in response to experiences.

An fMRI - generated connectome of the human brain that shows active connections between neurons (Credit: Alfred Pasieka / Science Photo Library)

In the future, Markram could always incorporate information from connectomes into Blue Brain.

Filling the gap: adding super-resolution to array tomography for correlated ultrastructural and molecular identification of electrical synapses at the C. elegans connectome.

Stanford's Snyder is pleased about the growing push to understand human biological variation via personal connectome and other «- ome» profiles, such as metabolomes (the total metabolites present at a given time in our bodies) and proteomes (ditto for proteins).

«This confirms that while unique to each individual, some aspects of the family connectome are inherited and maintained throughout development and may be useful as early biomarkers of mental or neurological conditions,» said lead author Oscar Miranda - Dominguez, Ph.D., research assistant professor of behavioral neuroscience, OHSU School of Medicine.

Since no cortical connectome is known yet, it's not clear how to connect the model neurons with each other.

That's why the organization of the parts is so important, and why connectomes are more crucial for humans than for worms.

His computer models were able to learn, so Seung wondered if there might be a way to test those models against the actual connectome to see if Hebb's assumptions were right.

«The structural connectome provides us with a way to characterize and measure these connections and how they change through disease or age,» said study co-author Jeffrey W. Prescott, M.D., Ph.D., radiology resident at Duke University Medical Center in Durham, N.C.

FlyEM Reconstruction creates algorithms, techniques, and software for EM - based connectome reconstruction and makes them accessible for public consumption.

Further processing and analysis uses cutting - edge connectome analysis algorithms and software that we publish in public software repositories under open - source licenses.

Drosophila circuits underlying identified behaviors are being reconstructed in the pipeline with the goal of generating a complete Drosophila connectome.

The goal of the FlyEM Project is to produce and analyze connectomes of behaviorally - relevant neural circuits in the entire Drosophila nervous system using electron microscopy.

In addition to establishing and publishing a fly connectome, FlyEM will make technology and methodology available that is needed to perform large - scale EM reconstructions.

«You couldn't ask for a smaller [connectome] dataset than that, and it's impossibly complicated,» Lichtman says.

Science is traditionally experimental, whereas connectome mapping is descriptive.

Even that 302 - neuron C. elegans worm connectome is too much for most people, and it's more on the order of 12 terabytes.

Thus far, the only complete neuronal connectome that has been mapped is that of the nematode Caenorhabditis elegans.

But neuroscientists such as Sporns, while praising the accomplishments of Sanes and Lichtman as admirable, question the necessity of a neuron - to - neuron connectome.

These rich data will also allow us to quantify genetic (Chiang et al., 2009) and behavioral variation of white matter fiber pathways and functional correlations for analysis by the entire community, and help define an optimized methodology for collection of a definitive connectome dataset using DSI (V. J. Wedeen, 2005).

They didn't focus merely on individual regions, but assessed the entire functional brain connectome — which represents how each region is functionally connected to every other region of the brain.

The full mouse connectome would produce hundreds of times more data than can be found on all of Google's computers, says Jeffrey Lichtman, the neuroanatomist leading the Harvard team.

That changed in late 2009, when researchers at the Nathan S. Kline Institute for Psychiatric Research in Orangeburg, New York, released resting - state functional MRI (fMRI) data into the NITRC from more than 1,200 volunteers, collected for the 1000 Functional Connectomes Project (FCP).

Only one animal's full connectome has been constructed thus far: the roundworm C. elegans, which has a mere 302 neurons and serves as the model for research and data sharing in the field.

An fMRI - generated connectome of the human brain that shows active connections between neurons

On the mis - presentation and misinterpretation of gender - related data: the case of Ingalhalikar's human connectome study.

You need to look at every cubic millimeter of brain to see every synapse, which is necessary to map the brain's connectome in full.

«With synchrotron X-ray imaging, mapping the human connectome at single - neuron resolution is now more realistic,» Chiang says.

«It is known that water prefers moving along the defined physical connections between regions in the brain, which makes DTI a great tool for evaluating the structural connectome,» Dr. Prescott said.

The connectome scanner at Massachusetts General Hospital helps to map the brain's connections.

Once we model the connectome — the million billion points of contact between neurons in the brain — we'll glimpse the anatomy of the mind.

In April, researchers led by Hongkui Zeng of the Allen Institute for Brain Science in Seattle assembled the first road map of neural pathways — called a connectome — inside the mouse brain (left).

New efforts to trace the neural «connectome» — all the nodes and pathways in the brain — produce vivid images of the maps in our minds.

It should then be possible to produce an «autism connectome», say, that can be compared with the healthy connectome just published.

Connectomes have been drawn up for other animals, including humans, but they are much cruder.

The mouse connectome will be a model for years to come»

In an era of increasing excitement about mapping the brain's «connectome,» this finding fits with our growing understanding of complex brain functions as residing not in discrete brain regions, but in densely connected networks of neurons spread throughout different parts of the brain.