These regions tend to be
conserved over evolution, and scientists have thus assumed that too many mutations in these regions are fatal.
Not exact matches
In today's issue of Cell, a team reports that it has found in mice and humans a close relative of a fruit fly clock gene — the first evidence that some of these genes may have been
conserved over the course of
evolution.
What I find most interesting is the idea that the embryonic tissue that goes on to form limb and the motor neurons is regulated by coordinated molecular mechanisms — under the guidance of a genetic program that has been
conserved over the course of
evolution.
«One of the basic rules of
evolution is that which is functional tends to be
conserved over time,» says Edward Rubin, a geneticist at the Lawrence Berkeley National Laboratory in California.
«Statistically speaking, the probability that a highly
conserved DNA sequence will change multiple times
over 6 million years of
evolution is close to zero».
This has revealed an ancient reproductive requirement in the Urbilaterian, the common ancestor of all bilaterian animals and highlights a fundamental reproductive function associated with Boule protein
conserved over six hundred million years of
evolution.