Sentences with phrase «considerable risk of»

However, many of these studies have considerable risk of bias, and if we only focused on trials with low risk of bias, there would no longer be enough studies to detect clinically relevant effects.

Questions remain, however, about how best to enable improvements in parenting in vulnerable families where parenting skills are poor, social and environmental risk factors are high, and a considerable risk of abuse or neglect exists.

[at para 38] Also by dint of his former life as a police officer Barros recognized something perhaps a little less obvious to the layperson: when a C.I.'s cover is blown, crown and police will often choose to stay proceedings against an accused rather than continue on to trial where the informant's identity will become public subjecting them to considerable risk of harm.

And therefore: (1) the problem has been allowed to become worse for decades; (2) we are still a long way from a solution; and as a result, (3) we are at considerable risk of government intervention by way of either: (a) socialized law, or, (b) free enterprise law, allowing non-lawyer ownership of law firms.

While car and truck operators have the added protection of their vehicle's structure, the open nature of a motorcycle places cyclists at a considerable risk of injury and death.

Once more, the AG argues this is a task for national courts, but he nonetheless points out that a general data retention obligation entails a considerable risk of mass surveillance (§ 256).

With so much of this oil crossing the United States via pipeline and rail, there is considerable risk of spills and it is not right that they are able to avoid these oil spill liability trust fund fees.

They thereby run the considerable risk of being overly influenced by the author (s) of the secondary literature.

The show takes the considerable risk of starting not with a punchy, scene - setting overture, but a roomful of intriguing, mostly small early paintings by key figures.

Given these factors, we believe it will be increasingly difficult for Take - Two to create sustainable shareholder value and that Take - Two remains exposed to considerable risk of value loss.

Risk Warning: Trading CFDs carries a considerable risk of capital loss.

At the recent market low, the Market Climate could certainly not be characterized as favorable, but at the present overbought level, there is considerable risk of a fresh plunge.

In other words, an investor is more likely to do well by achieving consistently good returns with limited downside risk than by achieving volatile and sometimes even spectacular gains but with considerable risk of principal.

I believe that there is considerable risk of their overdoing it and ending up with a strong bout of inflation.

Our everyday, traditional ideas of reality are delusions which we spend substantial parts of our daily lives shoring up, even at the considerable risk of trying to force facts to fit our definition of reality instead of vice versa.

There is a considerable risk of serious adverse effects from cyanide poisoning after laetrile or amygdalin, especially after oral ingestion.

@Carpetsmoker «some dutch» would mean that there is a considerable risk of saying something wrong.

Republicans are also at considerable risk of losing California's 39th and 49th districts, which are open because of retirements.

While I have been a little torn in the past about agreeing with the recommendation of the American Academy of Pediatrics for a «ban on the manufacture and sale of mobile infant walkers,» I do now agree «because data indicate a considerable risk of major and minor injury and even death from the use of walkers, and because there is no clear benefit from their use.»

Even so, historical considerations that have been effective in market cycles across history (and that also would have captured the majority of the market advance since 2009) presently suggest considerable risk of what we've often called an «air pocket» — similar to what we observed last October — over the coming 10 - 12 weeks, with much more severe downside risk possible over the course of the next 18 - 24 months.

And our traditional sources seem at considerable risk of drying up.

«There are considerable risks of misclassification and misinterpretation in the use of VAM to inform these evaluations.»

These important insights in turn suggests that poor defense representation or differences in the quality of defense counsel may create considerable risks of disparities and other unfair sentencing outcomes under the Guidelines.

Not exact matches

The presence of additional US ground troops inside Syria — even miles from the frontline — would bring with it considerable risk.

Even national brands face a daunting challenge: last year, just 20 % of High Liner's wild - caught seafood came from certified fisheries — a level that exposes the company to considerable commercial risk.

But given the considerable risks, it's not for the faint of heart or those without business experience.

Such capital - intensive growth is not without considerable risks, but investing in more than you need — C.R. Plastic's latest home is three times the size of its previous headquarters — can be smart, «[if] you've got good market indicators that you will grow into it,» according to Susan Rohac, vice-president of growth and transition capital for Ontario and Atlantic Canada at BDC.

Regardless, investments in both early - stage and late - stage companies involve a considerable amount of risk.

What's clear in the IMF analysis is that the projections for both debt and financing needs are at «considerable» risk of being missed due to the optimistic assumptions that underpin the figures:

We live with considerable uncertainty about the sustainability of the pattern of global capital flows and the relatively low risk premia that prevail today.

«Given the absence of rules that would discipline the financial activity and their supervision, the activity of these entities is characterized by a considerable risk and uncertainty, and does not guarantee the protection of customers against investment loss.

THE QUOTE: «The U.S. dollar has put on a compelling show overnight as the stars align on the back of higher U.S. yields and a considerable reduction in the U.S. dollar's geopolitical risk premium as an outwardly calmer mood surrounding trade and geopolitical risk takes hold,» Stephen Innes of OANDA said in a commentary.

We live with considerable uncertainty about the sustainability of the pattern of relatively low risk premia and reduction in the cost of insurance against future macroeconomic and financial volatility.

In summary, evidence suggests that cryptocurrencies comprise a new asset class, potentially (but with considerable risk) useful as a diversifier of conventional asset classes.

In light of the considerable efforts under way to implement a macroprudential approach to enhance financial stability and the increased focus of policymakers on monitoring emerging financial stability risks, I see three key principles that should guide the interaction of monetary policy and macroprudential policy in the United States.

Secondly, the value of fixed income instruments will become impaired (perhaps significantly given that mortgages have considerable duration / extension risk) as rates rise; such impairments will hit bank equity, and could lead to risk reduction maneuvers.

While trading in binary options comes with a considerable level of risk, using the YesOption online trading platform makes thing s a lot easier for both the novice traders as well as the professional traders in the financial market.

Risk of loss associated with foreign exchange trading may be very considerable.

While numerous crypto exchanges are offering their services, the pitfalls of centralized systems plus the often unfair trading fees, arbitrary rules and security threats add considerable risk for users.

Lastly, the Bank has noted considerable uncertainty around geopolitical risks, in particular the ongoing renegotiation of the North American Free Trade Agreement (NAFTA).

Historian Daniel Howe observes that the Unitarian clergy fomented considerable dissent in Massachusetts against the U. S. annexation of Texas by portraying the Texans as irresponsible speculators who had entered Mexico at their own risk.

What is surprising at first is the fact that Ben Sira takes special care to warn his students of the considerable risks that follow from loaning money.

It is not surprising that Europeans are prepared to pay a considerable amount to reduce the risk of such a change.

If the divine mystery is present in a special way among the poorest and most misused of his or her children, as the biblical images and stories — from the slaves in Egypt to the official lynching of Jesus — constantly remind us, then allegedly religious people who insulate themselves from the city are putting themselves at considerable risk.

We recognize that this approach carries with it certain dangers, particularly that of accommodationism, and yet it is also true that it has brought about considerable success, from Japan to Paraguay; whether the risk is worth the reward is a point we could debate.

Since the risks of digital technology may lead to considerable damage a call for international rules that would establish liability and damage compensation has emerged.

It must have been very disconcerting; they probably ran the risk of crashing in considerable disorder, and getting gobbled up.

engagement in business transactions involving considerable risk but offering the chance of large gains, especially trading in commodities, stocks, etc., in the hope of profit from changes in the market price.

«I would regard the acquisition of any artifact likely from Iraq... as carrying considerable risk,» that expert told the company in an in - house memo.

Indeed, its advantages might seem considerable: it treats the root of the problem and not only its symptoms, thereby avoiding the risk of passing the disorder on to future generations.