Sentences with phrase «constant region»

At the heart of the delivery platform is the «linker,» a lipoprotein that binds to the antibody constant region.

The company now has an array of fully human antibodies in its pipeline created with its proprietary VelocImmune mouse, which has been engineered to express human antibody genes while still mounting a robust immune response by making antibodies with fully human variable regions and mouse constant regions.

Background mutation rates by this method is ∼ 1 base - exchange per 1,000 bases sequenced (based on sequences of constant region gene segments).

When low levels of antibodies from a previous dengue infection sense a new serotype is around, they weakly bind to the different serotype, lead it to cells with receptors for their constant regions, and the new serotype ultimately enters those cells.

Many researchers have explored ways to eliminate cell receptors from recognizing the constant region of dengue antibodies; however, traditional immunization techniques are generally incapable of creating antibodies that can not bind to these receptors.

The other end, known as the constant region, binds to receptors on the surface of cells that can direct the immune system to respond in a variety of ways, all in the hopes of eliminating the target on the variable end of the antibody.

However, the dengue virus uses this natural process to its advantage: the cells that recognize the constant region of an antibody are the exact cells dengue virus prefers to infect.

To simplify the production of idiotype vaccines, we expressed the single - chain form of the idiotype (scFv), which includes only the VH / VL domains and no constant regions, in a polypeptide of ≈ 30 kDa.