Sentences with phrase «constitutive associations»

Liberalism's founders tended to take for granted the persistence of social norms, even as they sought to liberate individuals from those constitutive associations and the accompanying education in self - limitation that sustained these norms.

Constitutive association of the proapoptotic protein Bim with Bcl -2-related proteins on mitochondria in T cells.

Not exact matches

It now follows that the constitutive principles of this association must also be legal in character; that is, an institutional process through which governing activities are properly determined must itself be coercively enforced.

As Hobbes's illustration to the Leviathan so eloquently depicted, an increasingly «liberated» citizenry, resulting from the diminishment of constitutive memberships in social groups and associations, would be connected only through one bond, one relation, one connection» the state.

This point of view counters the narrow applications of theatrical imagery by emphasizing the constitutive and transformative impact of Word and resists the casual association between «performance» and narcissism by stressing that self is social and is constituted by «speaking», «acting» and «joining together» in communion.

Here, we report that unphosphorylated STAT6 is present in the nucleus and may facilitate constitutive COX - 2 expression in NSCLC cells via binding to the COX - 2 promoter in association with p300.

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10

In summary, our study in human NSCLC cells demonstrates that unphosphorylated STAT6 contributes to constitutive COX - 2 transcription via binding to the COX - 2 promoter in association with transcription coactivator p300.