Associative learning and memory was analyzed in
a context fear conditioning paradigm (Figure 3E).
Those mice were unsuccessful with
context fear conditioning, but they did as well as wild - type mice when they were treated with memantine.
To get a grasp of the proteins involved in a particular learning process, the investigators studied
context fear conditioning in mice.
Context fear conditioning demands that the hippocampus, a region of the brain important for memory formation, be functional.
Not exact matches
Fearing objects or
contexts can be learned; in animals this is being studied as
fear conditioning, which depends on the emotional circuitry of the brain.
In contextual
fear conditioning, experimental subjects are placed in an emotionally neutral
context (such as a room) and presented an aversive stimulus (such as an electrical shock).
The hippocampus and the amygdala are required for
fear memory where the hippocampus is involved in the formation and retrieval of
context fear associations and the amygdala is involved in
conditioning and recall of associations to contextual and discrete cues [18, 19].
The read - out that is measured in contextual and cued
fear conditioning is a freezing response that occurs following the pairing of an unconditioned stimulus (US), such as a foot shock, with a
conditioned stimulus (CS), such as a particular
context or cue (tone)[15 — 17].
The readout that is measured in contextual and cued
fear conditioning is a freezing response that occurs following the pairing of an unconditioned stimulus such as a foot shock, with a
conditioned stimulus such as a particular
context or cue (tone).