Sentences with phrase «contextual fear conditioning»

The mutant mice performed normally in contextual fear conditioning, but were impaired in the ability to distinguish two similar contexts.

To gain more insights into the role of genes in memory formation, Jun Cho et al. used ribosome profiling and RNA - sequencing of the mouse hippocampus after contextual fear conditioning, a process in which the mice received a small electric shock in a particular setting, forming a strong memory associating that setting with the shock.

In the fear conditioning paradigm, animals can also learn to associate the environment with the aversive stimulus; therefore, we tested contextual fear conditioning behavior 24 h later in the same arena, and compared it to the average freezing response during the pre-training habituation session (which averaged ~ 10 % freezing).

In 13 - month old transgenic rats with advanced amyloid pathology we revealed marked contextual fear conditioning deficits in homozygote animals.

Both hippocampal synaptic density and LTP as well as contextual fear conditioning and spatial learning vary as a function of maternal care in the rat [10], [15].

Regulation of presynaptic Ca2 +, synaptic plasticity and contextual fear conditioning by a N - terminal β - amyloid fragment.

Following contextual fear conditioning, we then tested fear memory retrieval in response to an auditory cue, within a different environment.

Following two days of habituation and animal handling, auditory fear conditioning was tested (a, d) followed by assessment of contextual fear conditioning 24 h later (b, e).

No differences in freezing responses between non-transgenic and transgenic rats were detected during contextual fear conditioning testing at this early stage (F2, 21 = 1.043; p > 0.05)(Figure 6b).

Using a genetic approach to increase spine turnover, they show that higher pre-learning spine turnover positively correlates with learning and memory performance in contextual fear conditioning and Morris water maze.

Fos ecRNA was induced by memory - forming experiences in rats, and knockdown of Fos ecRNA in a region of the rat hippocampus significantly impaired long - term memory formation after contextual fear conditioning.

Note the progression of auditory and contextual fear conditioning deficits as the amyloid pathology advanced from pre - to post-plaque stages.

In contextual fear conditioning, experimental subjects are placed in an emotionally neutral context (such as a room) and presented an aversive stimulus (such as an electrical shock).

Contextual fear conditioning has previously been carried out with the huAPP / PS1 mice where 11 - month - old AD mice spent significantly less time freezing in response to the context than wild type controls [44].

On day 3, contextual fear conditioning was evaluated by placing the animals in the chamber during 8 min.

Aged C3 - deficient mice also performed significantly better than WT mice in the contextual fear conditioning task, which evaluates memory associated with aversive stimuli, and C3 - deficient mice display reduced anxiolytic behavior, evaluated via the elevated plus maze and open - field assessment.

By two hippocampal - dependent memory tests, the Morris water maze and contextual fear conditioning, rivastigmine improved the memory

By two hippocampal - dependent memory tests, the Morris water maze and contextual fear conditioning, rivastigmine improved the memory... deterioration of the T2DM - AD mice (n = 8, p < 0.01).