The results were mixed and showed that castration did inhibit
contextual fear memory processing, supporting the fact that the processing of
contextual fear memory within the hippocampus area of the brain is testosterone dependent.
It is established that men tend to develop post-traumatic stress disrorder less frequently and of a less severe nature than women due to this inhibition of
contextual fear memory inhibition3.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have now for the first time identified a sub-region in the brain that works to form a particular kind of memory: fear - associated with a specific environmental cue or «
contextual fear memory.»
Projections to and from the nucleus reunions in the thalamus regulate the specificity of
contextual fear memory.
Not exact matches
We realized that this could be an exciting finding that may account for how
contextual information is processed and conveyed between brain areas for the formation of
fear memory for the context associated with an aversive event.»
They then performed serial behavioral tests on the mice, including Y - maze test (to assess working
memory), rotarod test (motor function and learning), and
contextual and cued
fear condition test (
fear learning and
memory).
Following
contextual fear conditioning, we then tested
fear memory retrieval in response to an auditory cue, within a different environment.
The hippocampus and the amygdala are required for
fear memory where the hippocampus is involved in the formation and retrieval of context
fear associations and the amygdala is involved in conditioning and recall of associations to
contextual and discrete cues [18, 19].
Using a genetic approach to increase spine turnover, they show that higher pre-learning spine turnover positively correlates with learning and
memory performance in
contextual fear conditioning and Morris water maze.
In the
fear conditioning paradigm, only the combination of J147 and donepezil rescued the hippocampal - dependent deficit in
contextual and cued
fear conditioning, suggesting the compounds» synergistic effect for this particular type of
memory (Figure 4C, D).
(C) On Day 2 of the
fear conditioning assay the amount of time freezing in response to the environment is measured as
contextual memory.
Aged C3 - deficient mice also performed significantly better than WT mice in the
contextual fear conditioning task, which evaluates
memory associated with aversive stimuli, and C3 - deficient mice display reduced anxiolytic behavior, evaluated via the elevated plus maze and open - field assessment.
By two hippocampal - dependent
memory tests, the Morris water maze and
contextual fear conditioning, rivastigmine improved the
memory