«We don't know why conversion of fibroblasts to
the contractile phenotype is sometimes helpful and sometimes harmful.
The isometric contractile properties of EDL muscles from IL - 15Rα — KO mice were also consistent with the adoption of a slower
contractile phenotype.
Isometric contractile properties of fast muscles from IL - 15Rα — KO mice display a slower
contractile phenotype.
Fast muscles displayed fatigue resistance and a slower
contractile phenotype.
Specifically, lower isometric forces coupled with a lower twitch / tetanus ratio and lower rates of force development and relaxation indicate that EDL muscles from IL - 15Rα — KO mice have adopted a slower
contractile phenotype.
Not exact matches
Because the
phenotypes were distinct in these knockout mouse models with respect to spontaneous cage activity and fast muscle isometric
contractile characteristics, we can conclude that the roles of IL - 15Rα and IL - 15 in vivo are distinct with regard to muscle function.
On this basis, we propose that IL - 15Rα has a role in determining the
contractile and morphological
phenotypes of fast skeletal muscles in vivo.