Supported by National Institutes of Health grants, researchers at Oak Ridge National Laboratory (ORNL), the University of Tennessee (UT), and the UT — ORNL Joint Institute for Computational Sciences (JICS) discovered a molecular «switch» in a receptor that
controls cell behavior using detailed molecular dynamics simulations on a computer called Anton built by D. E. Shaw Research in New York City.
Not exact matches
The findings, published by
Cell Press in the March 8 issue of the journal Neuron, may help to explain why young children often struggle to
control selfish impulses, even when they know better, and could impact educational strategies designed to promote successful social
behavior.
«The key point here is that we can say something about how the gene acts to influence this
behavior — that is, is by functioning as a chemical messenger in
cells that
control this
behavior in the brain.
By manipulating chemical reactions,
behaviors of
cells can be mimicked resulting in chemical factories on the nanoscale
controlled and not by physical touch but by magnets and light.
Next, Anderson and his colleagues used a set of genetic tools to identify exactly which neurons were responsible for the effect on aggression and to see if the gene that encodes for Tk also
controls aggressive
behavior by acting in that
cell.
In cancer
cells, the protein networks that
control the
behavior are changed in such a way as to cause the
cells to lose
control and break away — a mutated skin
cell, for instance, might then migrate into the bloodstream.
MIT neuroscientists have discovered that brain
cells called glial
cells play a critical role in
controlling appetite and feeding
behavior.
«This shows that there are more
cells that modulate signals and exert temporal
control in areas regulating reproductive, social and parenting
behaviors in females than in males, with one exception so far,» says CSHL Associate Professor Pavel Osten, the team leader.
Based on anatomy and molecular markers, we propose that it arose by duplication of a neighboring stem
cell, which may have enabled finer neuronal
control over leg - related
behaviors, such as walking and grooming.»
Scientists think that these niches
control stem
cell behavior, that is «telling» the stem
cell when to produce more stem
cells or when to produce daughter
cells that will be the workhorses for that tissue or organ.
Known as Agrp neurons, these
cells also
control repetitive, stereotypic
behaviors in mice when food is not available, the researchers discovered.
The team, led by Stephen Liberles, Harvard Medical School associate professor of
cell biology, has effectively deconstructed the vagus nerve, a key connection between body and brain that is important because it
controls not only breathing but also heart rate, feeding
behavior and responses to illness.
«Cerebrospinal fluid signals
control the
behavior of stem
cells in the brain.»
Researchers use heated magnetic nanoparticles to manipulate nerve
cells and
control simple
behavior in nematodes
In studying the functional
behavior of the brain, from
control of muscles to the formation of memories, scientists are using such tools such as electron microscopy, recordings of electrical signals from individual brain
cells, and imaging of brain structures and processes using functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and high - resolution optical imaging.
Amita Sehgal, PhD, a professor of Neuroscience at the Perelman School of Medicine, University of Pennsylvania, describes in
Cell a circuit in the brain of fruit flies that
controls their daily, rhythmic
behavior of rest and activity.
The researchers traced the output of those
cells to the hypothalamus, which is known to
control behaviors associated with anxiety (in people, those include increased heart rate, avoidance, and secretion of stress hormones).
Next, they hope to study exactly how PER1
controls appetite and eating
behavior — whether its molecular actions work through the liver, fat
cells, brain or other organs.
The wiring diagrams look like colorful threads on a tapestry, and they're clear enough to show which
cell clusters
control specific
behaviors.
The team led by Rory Fisher, Ph.D., professor of pharmacology in the UI Carver College of Medicine, has identified a protein called RGS6 (regulator of G protein signaling 6) that acts through two separate mechanisms to
control alcohol - seeking
behavior and alcohol - induced
cell death in heart, liver, and other organs.
The first genetically encoded optical tool that can precisely
control brain
cells (neurons) by the millisecond, optogenetics allows for light - induced
control of neuronal activity, helping researchers understand how neurons form circuits that
control behavior.
It is an enormously complicated and interdependent set of
controls, still poorly understood to be sure, but the ability to change protein levels is in principle the ability to change
cell behavior.
By turning the anxiety
cells off and on using a technique called optogenetics, which allows scientists to
control the activity of neurons using beams of light, the researchers demonstrated that the anxiety
cells control anxiety - related avoidance
behaviors.
Dynamic actin filaments
control the mechanical
behavior of the human red blood
cell membrane.
As a cellular biologist Dr. Pilar Sanchez Gomez has been interested in the molecular mechanisms that
control adult neural stem
cell (NSC)
behavior.
The question of how cellular
behavior is
controlled is at the center of stem
cell biology, and understanding the mechanisms of
cell fate regulation is key for treating diseases that occur upon dysregulation, such as cancer or diabetes.
Albertin is interested in the way octopuses develop from single
cells to fully - fledged hatchlings, and fellow study author Yan Wang, also of the University of Chicago, told The Post she'd be studying how the octopus brain
controls complex
behavior, especially in relation to mating and reproduction.
The morphological changes manifested in the
cell types linked to larger toepads exemplify
cell type differentiation that must be
controlled by the physiology of reproduction and properly timed nutrient - dependent reproductive sexual
behavior, which probably occurs near the location of the higher perches.
Dr. Jennifer Garrison is interested in understanding how neuropeptides
control behavior at both the
cell biological and neural circuit level.
«Our ongoing project aims to elucidate how
cells recognize temperature or cellular events caused by the temperature changes and
control the expression of DESAT1 to adapt the cellular processes and
behaviors,» Umeda said.
Despite these findings, however, it is generally not clear how extrinsic cues are integrated within the
cell to
control the
behavior of
cell - intrinsic regulators of ES
cell pluripotency such as Oct4 [1].
Hormones are the regulatory biochemicals produced by our endocrine glands, whose job is to coordinate the
behavior of our
cells,
controlling everything from appetite to the choices we make in dangerous situations.
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